Results 171 to 180 of about 10,337 (219)

Enhancing Antileishmanial Activity of Amidoxime-Based Compounds Bearing a 4,5-Dihydrofuran Scaffold: In Vitro Screening Against Leishmania amazonensis. [PDF]

Molecules
Maia Santos Urbancg Moncorvo F, Avendaño Leon OL, Curti C, Kabri Y, Redon S, Torres-Santos EC, Vanelle P.   +6 more
europepmc   +1 more source

Amphotericin B resistance in Leishmania amazonensis: In vitro and in vivo characterization of a Brazilian clinical isolate. [PDF]

PLoS Negl Trop Dis
Ferreira BA, Coser EM, de la Roca S, Aoki JI, Branco N, Soares GHC, Lima MIS, Coelho AC.   +7 more
europepmc   +1 more source

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In vitro activity of cinnamaldehyde on Leishmania (Leishmania) amazonensis

Experimental Parasitology, 2022
Tegumentary leishmaniasis is an endemic disease that urgently needs new and effective treatments. L. amazonensis is one of the main species involved in the transmission of this infectious and non-contagious disease. The currently available treatments for leishmaniasis have high toxicity and vary in efficacy.
Aline Ávila Brustolin, Áquila Carolina Fernandes Herculano Ramos-Milaré, Tatiane França Perles de Mello, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Thaís Gomes Verzignassi Silveira   +5 more
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Leishmania amazonensis response to artemisinin and derivatives

Parasitology International, 2021
The worldwide presence of Leishmania parasites increases in the poorest regions. Current leishmaniasis treatments are unsatisfactory due to resistance development, side effects and cost. Herein, we describe the in vitro activity of artemisinin (ART), artemether (ATM), artesunate (ATS) and dihydroartemisinin (DHA) against Leishmania amazonensis ...
Laura, Machín, Rachel, Nápoles, Lars, Gille, Lianet, Monzote   +3 more
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Characterization of Leishmania (Leishmania) amazonensis promastigotes resistant to pentamidine

Experimental Parasitology, 2008
Pentamidine is a second-line agent used in the treatment of leishmaniasis and its mode of action and mechanism of resistance is not well understood. It was previously demonstrated that transfection of promastigotes and amastigotes with the ABC transporter PRP1 gene confers resistance to pentamidine.
Adriano C, Coelho, Luciana G, Gentil, José Franco, da Silveira, Paulo C, Cotrim   +3 more
openaire   +2 more sources

Biochemical characterization of serine transport in Leishmania (Leishmania) amazonensis

Molecular and Biochemical Parasitology, 2009
In addition to its role as a protein component in Leishmania, serine is also a precursor for the synthesis of both phosphatidylserine, which is a membrane molecule involved in parasite invasion and inactivation of macrophages, and sphingolipids, which are necessary for Leishmania to differentiate into its infective forms.
Marcos Gonzaga, dos Santos, Lisvane Silva, Paes, Ricardo Andrade, Zampieri, Maria Fernanda Laranjeira, da Silva, Ariel Mariano, Silber, Lucile Maria, Floeter-Winter   +5 more
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Antileishmanial activity of cordiaquinone E towards Leishmania (Leishmania) amazonensis

International Immunopharmacology, 2021
Leishmaniasis is caused by several protozoan species of Leishmania, and being endemically present in 98 countries around the world, it is also a severe public-health problem. The available antileishmanial drugs are toxic and yet present risks of recurrent infection. Efforts to find new, effective, and safe oral agents for the treatment of leishmaniasis
Raiza Raianne Luz, Rodrigues, Thaís Amanda Lima, Nunes, Alyne Rodrigues, de Araújo, José Delano Barreto, Marinho Filho, Marcos Vinícius, da Silva, Fernando Aécio de Amorim, Carvalho, Otília Deusdenia Loiola, Pessoa, Hozana Patrícia Silva, Freitas, Klinger Antonio da Franca, Rodrigues, Ana Jérsia, Araújo   +9 more
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Polyamine N-acetyltransferase in Leishmania amazonensis

Parasitology Research, 1996
N-Acetyltransferase, which is suggested to be responsible for the production of N1-acetylspermidine in Leishmania amazonensis and to be involved in the process of inactivation and degradation of excessive polyamines, was partially purified and characterized. Among the substrates tested, sym-norspermidine, sym-norspermine, and 1,3-diaminopropane had the
M, Rojas-Chaves, C, Hellmund, R D, Walter   +2 more
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Heme binding to Leishmania mexicana amazonensis

Molecular and Biochemical Parasitology, 1988
Leishmania mexicana amazonensis is a pathogenic parasite whose growth, due to a biosynthetic deficiency, is dependent on a supply of exogenous heme. Utilizing [55Fe]hemin, we have demonstrated that heme binding to non-dividing cultured promastigotes of L. m.
R A, Galbraith, M J, McElrath
openaire   +2 more sources