Results 1 to 10 of about 699 (89)

Imidazolium salts as an alternative for anti-Leishmania drugs: Oxidative and immunomodulatory activities

Frontiers in Immunology, 2023
In this study we explored the previously established leishmanicidal activity of a complementary set of 24 imidazolium salts (IS), 1-hexadecylimidazole (C16Im) and 1-hexadecylpyridinium chloride (C16PyrCl) against Leishmania (Leishmania) amazonensis and ...
Fernanda Giesel Baldissera, Fernanda Giesel Baldissera, Tiago Fazolo, Tiago Fazolo, Matheus Brasil da Silva, Paulo Cesar de Santana Filho, Vinícius Demétrio da Silva, David Max Rivillo Perez, Joice Sandra Klitzke, Eduardo Giovanni de Oliveira Soares, Luiz Carlos Rodrigues Júnior, Luiz Carlos Rodrigues Júnior, Alessandra Peres, Alessandra Peres, Eliane Dallegrave, Kely Campos Navegantes-Lima, Marta Chagas Monteiro, Henri Stephan Schrekker, Pedro Roosevelt Torres Romão, Pedro Roosevelt Torres Romão, Pedro Roosevelt Torres Romão   +20 more
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In vitro and in vivo Anti-leishmanial Potential of [Ag (PTA) 4 ]BF 4 and [Ag(HBPz 3 )(PPh 3 )] Silver Complexes

Revista da Sociedade Brasileira de Medicina Tropical, 2022
Background: American tegumentary leishmaniasis is a parasitic disease known for being difficult to treat; therefore, the search for more effective therapeutic methods is necessary.
Pauline de Faria Soldera, Ana Flavia da Silva Chagas, Anny Maisa Vargas Brasil, Claudia Dantas Comandolli-Wyrepkowski, Marina Porchia, Antonia Maria Ramos Franco Pereira   +5 more
doaj   +1 more source

In vitro and in vivo activity of a palladacycle complex on Leishmania (Leishmania) amazonensis. [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: Antitumor cyclopalladated complexes with low toxicity to laboratory animals have shown leishmanicidal effect. These findings stimulated us to test the leishmanicidal property of one palladacycle compound called DPPE 1.2 on Leishmania ...
Carolina de Siqueira Paladi, Isabella Aparecida Salerno Pimentel, Simone Katz, Rodrigo L O R Cunha, Wagner Alves de Souza Judice, Antonio C F Caires, Clara Lúcia Barbiéri   +6 more
doaj   +1 more source

Experimental infection and transmission of Leishmania by Lutzomyia cruzi (Diptera: Psychodidae): Aspects of the ecology of parasite-vector interactions. [PDF]

PLoS Neglected Tropical Diseases, 2017
Several parameters should be addressed before incriminating a vector for Leishmania transmission. Those may include its ability to become infected by the same Leishmania species found in humans, the degree of attractiveness for reservoirs and humans and ...
Everton Falcão de Oliveira, Elisa Teruya Oshiro, Wagner de Souza Fernandes, Paula Guerra Murat, Márcio José de Medeiros, Alda Izabel Souza, Alessandra Gutierrez de Oliveira, Eunice Aparecida Bianchi Galati   +7 more
doaj   +1 more source

Differentiation of Leishmania (L.) infantum, Leishmania (L.) amazonensis and Leishmania (L.) mexicana Using Sequential qPCR Assays and High-Resolution Melt Analysis

Microorganisms, 2020
Leishmania protozoa are the etiological agents of visceral, cutaneous and mucocutaneous leishmaniasis. In specific geographical regions, such as Latin America, several Leishmania species are endemic and simultaneously present; therefore, a diagnostic ...
Marcello Ceccarelli, Aurora Diotallevi, Gloria Buffi, Mauro De Santi, Edith A. Fernández-Figueroa, Claudia Rangel-Escareño, Said A. Muñoz-Montero, Ingeborg Becker, Mauro Magnani, Luca Galluzzi   +9 more
doaj   +1 more source

The diverse and dynamic nature of Leishmania parasitophorous vacuoles studied by multidimensional imaging. [PDF]

PLoS Neglected Tropical Diseases, 2012
An important area in the cell biology of intracellular parasitism is the customization of parasitophorous vacuoles (PVs) by prokaryotic or eukaryotic intracellular microorganisms.
Fernando Real, Renato A Mortara
doaj   +1 more source

Autophagic Induction Greatly Enhances Leishmania major Intracellular Survival Compared to Leishmania amazonensis in CBA/j-Infected Macrophages

Frontiers in Microbiology, 2018
CBA mouse macrophages control Leishmania major infection yet are permissive to Leishmania amazonensis. Few studies have been conducted to assess the role played by autophagy in Leishmania infection.
Beatriz R. S. Dias, Carina S. de Souza, Niara de Jesus Almeida, José G. B. Lima, Kiyoshi F. Fukutani, Thiale B. S. dos Santos, Jaqueline França-Cost, Jaqueline França-Cost, Claudia I. Brodskyn, Juliana P. B. de Menezes, Maria I. Colombo, Patricia S. T. Veras   +11 more
doaj   +1 more source

Analysis and chromosomal mapping of Leishmania (Leishmania) amazonensis amastigote expressed sequence tags

Memorias do Instituto Oswaldo Cruz, 2007
The characterization of expressed sequence tags (ESTs) generated from a cDNA library of Leishmania (Leishmania) amazonensis amastigotes is described. The sequencing of 93 clones generated new L. (L.) amazonensis ESTs from which 32% are not related to any
Luciana Girotto Gentil, Fernanda Lasakosvitsch, José Franco da Silveira, Márcia Regina Machado dos Santos, Clara Lúcia Barbiéri   +4 more
doaj   +1 more source

Distinct Macrophage Fates after in vitro Infection with Different Species of Leishmania: Induction of Apoptosis by Leishmania (Leishmania) amazonensis, but Not by Leishmania (Viannia) guyanensis. [PDF]

PLoS ONE, 2015
Leishmania is an intracellular parasite in vertebrate hosts, including man. During infection, amastigotes replicate inside macrophages and are transmitted to healthy cells, leading to amplification of the infection.
Jarina Pena DaMata, Bárbara Pinheiro Mendes, Kátia Maciel-Lima, Cristiane Alves Silva Menezes, Walderez Ornelas Dutra, Lirlândia Pires Sousa, Maria Fátima Horta   +6 more
doaj   +1 more source

IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis

Parasites & Vectors, 2017
Background Interleukin 32 (IL-32) is a pro-inflammatory cytokine induced in patients with American tegumentary leishmaniasis (ATL) caused by Leishmania braziliensis.
Rodrigo Saar Gomes, Muriel Vilela Teodoro Silva, Jéssica Cristina dos Santos, Lucas Luiz de Lima Silva, Aline Carvalho Batista, Juliana Reis Machado, Mauro Martins Teixeira, Miriam Leandro Dorta, Milton Adriano Pelli de Oliveira, Charles A Dinarello, Leo A. B. Joosten, Fátima Ribeiro-Dias   +11 more
doaj   +1 more source