The use of kDNA minicircle subclass relative abundance to differentiate between Leishmania (L.) infantum and Leishmania (L.) amazonensis [PDF]
Parasites & Vectors, 2017 Background Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia).
Marcello Ceccarelli +7 more
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Metabolomic Reprogramming of C57BL/6-Macrophages during Early Infection with L. amazonensis [PDF]
International Journal of Molecular Sciences, 2021 Leishmania survival inside macrophages depends on factors that lead to the immune response evasion during the infection. In this context, the metabolic scenario of the host cell–parasite relationship can be crucial to understanding how this parasite can survive inside host cells due to the host’s metabolic pathways reprogramming. In this work, we aimed
Maricruz Mamani-Huanca +5 more
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Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes [PDF]
FEBS Open Bio, 2019 Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug‐resistant strains has been observed. Therefore, new therapeutic targets against leishmaniasis are required. Several isoprenoid compounds, including dolichols or ubiquinones,
José Mário F. Balanco +5 more
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Comparing the Antileishmanial Activity of Gold(I) and Gold(III) Compounds in L. amazonensis and L. braziliensis in Vitro [PDF]
ChemMedChem, 2020 AbstractAbstract: A series of mononuclear coordination or organometallic AuI/AuIII complexes (1–9) have been comparatively studied in vitro for their antileishmanial activity against promastigotes and amastigotes, the clinically relevant parasite form, of Leishmania amazonensis and Leishmania braziliensis.
Karen Minori +4 more
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Leishmania (L.) amazonensis LaLRR17 increases parasite entry in macrophage by a mechanism dependent on GRP78 [PDF]
Parasitology, 2023 AbstractLeishmaniases affect 12 million people worldwide. They are caused by Leishmania spp., protozoan parasites transmitted to mammals by female phlebotomine flies. During the life cycle, promastigote forms of the parasite live in the gut of infected sandflies and convert into amastigotes inside the vertebrate macrophages.
Mauricio S. Peña +10 more
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Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis [PDF]
PLOS Neglected Tropical Diseases, 2019 Diffuse cutaneous leishmaniasis (DCL) is a rare form of leishmaniasis where parasites grow uncontrolled in diffuse lesions across the skin. Meta-transcriptomic analysis of biopsies from DCL patients infected with Leishmania amazonensis demonstrated an infiltration of atypical B cells producing a surprising preponderance of the IgG4 isotype. DCL lesions
Stephen M. Christensen +5 more
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FVB/NJ strain as a mouse model for cutaneous leishmaniasis by Leishmania (L.) amazonensis [PDF]
Memórias do Instituto Oswaldo CruzLeishmaniases encompass a spectrum of neglected diseases caused by parasites of the genus Leishmania, grouped in two forms: tegumentary and visceral leishmaniasis.In this study, we propose Friend Virus B NIH Jackson (FVB/NJ) mouse strain as a new experimental model of infection with Leishmania (Leishmania) amazonensis, the second most prevalent agent ...
Guilherme Moreira Paiva Carrara +1 more
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Py-CoMFA, docking, and molecular dynamics simulations of Leishmania (L.) amazonensis arginase inhibitors [PDF]
Scientific ReportsAbstractLeishmaniasis is a disease caused by a protozoan of the genus Leishmania, affecting millions of people, mainly in tropical countries, due to poor social conditions and low economic development. First-line chemotherapeutic agents involve highly toxic pentavalent antimonials, while treatment failure is mainly due to the emergence of drug ...
Priscila Goes Camargo +4 more
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Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2019 Three drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal and hepatic toxicities. Therefore, the investigation of new compounds is required.
Daiane Barros Dias Mendonça +7 more
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Metacaspase-binding peptide inhibits heat shock-induced death in Leishmania (L.) amazonensis [PDF]
Cell Death & Disease, 2017 AbstractLeishmania (Leishmania) amazonensis is an important agent of cutaneous leishmaniasis in Brazil. This parasite faces cell death in some situations during transmission to the vertebrate host, and this process seems to be dependent on the activity of metacaspase (MCA), an enzyme bearing trypsin-like activity present in protozoans, plants and fungi.
Mauricio S Peña +4 more
openaire +3 more sources