Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4. [PDF]
PLoS Pathogens, 2019 Leishmaniasis is a neglected tropical disease affecting millions of individuals worldwide. P2X7 receptor has been linked to the elimination of Leishmania amazonensis.
Mariana M Chaves +9 more
doaj +2 more sources
Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review [PDF]
Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira +3 more
wiley +2 more sources
Surface enolase is a virulence factor of Leishmania amazonensis metacyclic promastigotes involved in adhesion to macrophages [PDF]
Frontiers in MicrobiologyWe find that enolase, an evolutionarily conserved and multifunctional protein, is displayed on the cell surface of Leishmania amazonensis parasites in a developmentally regulated manner, associated with infectivity.
Franciane dos Santos Alves +7 more
doaj +2 more sources
Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis [PDF]
Acta Tropica, 2006 Experimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous form (DCL), the mechanisms are still unknown.
Af Ali U M, Costa +6 more
openaire +2 more sources
Aryl thiosemicarbazones: In vitro and immunomodulatory activities against L. amazonensis [PDF]
Experimental Parasitology, 2017 Leishmaniasis is an infection caused by different species of Leishmania genus. Currently, there is no vaccine available for Leishmania infections in humans and conventional treatments are limited due to side effects. Therefore, the development of new antileishmanial drugs is an urgent need. In present study, we evaluated the cytotoxicity in host cells,
Aline Caroline, da Silva +6 more
openaire +2 more sources
Leishmania (L.) amazonensis infection impairs reproductive and fetal parameters in female mice
Revista Argentina de Microbiología, 2021 Leishmaniasis is a group of parasitic zoonotic diseases caused by intracellular protozoans belonging to the genus Leishmania. Little is known about the effects that this parasitosis may have on the reproductive parameters and pregnancy of infected humans and pets.
Sánchez, María Belén +6 more
openaire +3 more sources
PLOS ONE, 2020 Leishmaniasis has been considered as emerging and re-emerging disease, and its increasing global incidence has raised concerns. The great clinical diversity of the disease is mainly determined by the species. In several American countries, tegumentary leishmaniasis (TL) is associated with both Leishmania amazonensis and L.
Bruna Soares de Souza Lima +7 more
openaire +4 more sources
The Expression of Mannose Receptors in Skin Fibroblast and Their Involvement in Leishmania (L.) amazonensis Invasion [PDF]
Journal of Histochemistry & Cytochemistry, 2005 Leishmania are protozoa that invade mononuclear phagocytes with the involvement of different ligand-receptor systems, including mannose receptors. Until now, scant data are available concerning the mechanisms that govern the infection of Leishmania in other host cell types such as fibroblasts.
Renata C, Hespanhol +4 more
openaire +3 more sources
Leishmania (L.) amazonensis-induced inhibition of nitric oxide synthesis in host macrophages [PDF]
Microbes and Infection, 2002 Inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production was demonstrated in J774-G8 macrophages infected with Leishmania (L.) amazonensis promastigotes. The downmodulation of NO production observed in infected and LPS-stimulated J774-G8 cells correlated with a reduction in inducible nitric oxide synthase (iNOS) activity.
Filomena M Perrella, Balestieri +5 more
openaire +2 more sources
Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis. [PDF]
PLoS Pathogens, 2008 The intracellular protozoan Leishmania replicates in parasitophorous vacuoles (PV) that share many features with late endosomes/lysosomes. L. amazonensis PVs expand markedly during infections, but the impact of PV size on parasite intracellular survival ...
Jude Wilson +6 more
doaj +1 more source