Results 21 to 30 of about 13,174,260 (209)

Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes. [PDF]

FEBS Open Bio, 2019
Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug‐resistant strains has been observed. Therefore, new therapeutic targets against leishmaniasis are required. Several isoprenoid compounds, including dolichols or ubiquinones,
Balanco JMF, Sussmann RAC, Verdaguer IB, Gabriel HB, Kimura EA, Katzin AM.   +5 more
europepmc   +5 more sources

Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis. [PDF]

PLoS Negl Trop Dis, 2019
Diffuse cutaneous leishmaniasis (DCL) is a rare form of leishmaniasis where parasites grow uncontrolled in diffuse lesions across the skin. Meta-transcriptomic analysis of biopsies from DCL patients infected with Leishmania amazonensis demonstrated an infiltration of atypical B cells producing a surprising preponderance of the IgG4 isotype. DCL lesions
Christensen SM, Belew AT, El-Sayed NM, Tafuri WL, Silveira FT, Mosser DM.   +5 more
europepmc   +5 more sources

FVB/NJ strain as a mouse model for cutaneous leishmaniasis by Leishmania (L.) amazonensis. [PDF]

Mem Inst Oswaldo Cruz
Leishmaniases encompass a spectrum of neglected diseases caused by parasites of the genus Leishmania, grouped in two forms: tegumentary and visceral leishmaniasis.In this study, we propose Friend Virus B NIH Jackson (FVB/NJ) mouse strain as a new experimental model of infection with Leishmania (Leishmania) amazonensis, the second most prevalent agent ...
Carrara GMP, Stolf BS.
europepmc   +4 more sources

Aryl thiosemicarbazones: In vitro and immunomodulatory activities against L. amazonensis [PDF]

Experimental Parasitology, 2017
Leishmaniasis is an infection caused by different species of Leishmania genus. Currently, there is no vaccine available for Leishmania infections in humans and conventional treatments are limited due to side effects. Therefore, the development of new antileishmanial drugs is an urgent need. In present study, we evaluated the cytotoxicity in host cells,
Aline Caroline, da Silva, Thiago André Ramos, Dos Santos, Isis Viviane Bezerra, da Silva, Marcos Victor Gregório, de Oliveira, Diogo Rodrigo Magalhães, Moreira, Ana Cristina Lima, Leite, Valéria Rêgo Alves, Pereira   +6 more
openaire   +2 more sources

Insights into Divergent Leishmaniasis Pathogenesis: A Quantitative Flagellar Proteomic Comparison of <i>L. mexicana</i>, <i>L. amazonensis</i>, and <i>L. infantum</i>. [PDF]

Microorganisms
Leishmaniasis, a neglected tropical disease endemic to 98 countries, affects more than 300 million people worldwide. The disease is transmitted through the bite of infected female phlebotomine sand flies harboring Leishmania parasites. Although infection initiates at the cutaneous inoculation site, Leishmania species exhibit distinct tissue tropisms ...
Patel DL, Kim SY, Uchakina O, Clermont NA, Hyun JB, Patni AD, Patel MP, Khan S, Rana DK, Na CH, Cha SJ.   +10 more
europepmc   +2 more sources

Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis [PDF]

Acta Tropica, 2006
Experimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous form (DCL), the mechanisms are still unknown.
Af Ali U M, Costa, Ana L, Abreu, Claudia M C, Gomes, Ana C R, Saldanha, A, Barral, Jackson M L, Costa, Carlos E P, Corbett   +6 more
openaire   +2 more sources

Murine T Cell-Dependent Response Affects Leishmania amazonensis Amastigote Survival and Virulence. [PDF]

Cell Biol Int
ABSTRACT Our group has previously described the infection course of Leishmania amazonensis in BALB/c and BALB/cnu/nu mice, which have distinct T‐cell dependent responses. In this study, lesion‐derived amastigotes exhibited differential protein expression in a host‐dependent manner.
Soares GHC, Barbosa GR, Stolf BS.
europepmc   +2 more sources

Py-CoMFA, docking, and molecular dynamics simulations of Leishmania (L.) amazonensis arginase inhibitors. [PDF]

Sci Rep
AbstractLeishmaniasis is a disease caused by a protozoan of the genus Leishmania, affecting millions of people, mainly in tropical countries, due to poor social conditions and low economic development. First-line chemotherapeutic agents involve highly toxic pentavalent antimonials, while treatment failure is mainly due to the emergence of drug ...
Camargo PG, Dos Santos CR, Girão Albuquerque M, Rangel Rodrigues C, Lima CHDS.   +4 more
europepmc   +4 more sources

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum. [PDF]

Chem Biodivers
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
de Freitas CS, da Silva EOS, Tristão DC, Antar GM, Lage DP, Abrão DM, Antinarelli LMR, Coimbra ES, Lago JHG, Coelho EAF.   +9 more
europepmc   +2 more sources

Leishmania (L.) amazonensis infection impairs reproductive and fetal parameters in female mice

Revista Argentina de Microbiología, 2021
Leishmaniasis is a group of parasitic zoonotic diseases caused by intracellular protozoans belonging to the genus Leishmania. Little is known about the effects that this parasitosis may have on the reproductive parameters and pregnancy of infected humans and pets.
Sánchez, María Belén, Germano, Maria Jose, Salomón, María Cristina, Scelta, Julieta, Garcia Bustos, Maria Fernanda, Ginevro, Paula María, Cargnelutti, Diego Esteban   +6 more
openaire   +3 more sources