Results 41 to 50 of about 13,174,260 (209)

Kaurenoic Acid Possesses Leishmanicidal Activity by Triggering a NLRP12/IL-1β/cNOS/NO Pathway

Mediators of Inflammation, 2015
Leishmania amazonensis (L. amazonensis) infection can cause severe local and diffuse injuries in humans, a condition clinically known as American cutaneous leishmaniasis (ACL).
Milena Menegazzo Miranda, Carolina Panis, Suelen Santos da Silva, Juliana Aparecida Macri, Natalia Yoshie Kawakami, Thiago Hideki Hayashida, Tiago Bervelieri Madeira, Vinicius Ricardo Acquaro, Suzana Lucy Nixdorf, Luciana Pizzatti, Sérgio Ricardo Ambrósio, Rubens Cecchini, Nilton Syogo Arakawa, Waldiceu Aparecido Verri, Ivete Conchon Costa, Wander Rogério Pavanelli   +15 more
doaj   +1 more source

Leishmania amazonensis exhibits phosphatidylserine-dependent procoagulant activity, a process that is counteracted by sandfly saliva

Memorias do Instituto Oswaldo Cruz, 2013
Leishmania parasites expose phosphatidylserine (PS) on their surface, a process that has been associated with regulation of host's immune responses.
Natalia Cadaxo Rochael, Luize Goncalves Lima, Sandra Maria Pereira de Oliveira, Marcello Andre Barcinski, Elvira Maria Saraiva, Robson Queiroz Monteiro, Lucia Helena Pinto-da-Silva   +6 more
doaj   +1 more source

DH82 Canine and RAW264.7 Murine Macrophage Cell Lines Display Distinct Activation Profiles Upon Interaction With Leishmania infantum and Leishmania amazonensis

Frontiers in Cellular and Infection Microbiology, 2020
Leishmaniasis is an anthropozoonotic disease, and dogs are considered the main urban reservoir of the parasite. Macrophages, the target cells of Leishmania sp., play an important role during infection.
Natalia Rocha Nadaes, Leandro Silva da Costa, Raissa Couto Santana, Isabel Ferreira LaRocque-de-Freitas, Áislan de Carvalho Vivarini, Deivid Costa Soares, Amanda Brito Wardini, Ulisses Gazos Lopes, Elvira M. Saraiva, Celio Geraldo Freire-de-Lima, Debora Decote-Ricardo, Lucia Helena Pinto-da-Silva   +11 more
doaj   +1 more source

An in vitro model of antibody-enhanced killing of the intracellular parasite Leishmania amazonensis. [PDF]

PLoS ONE, 2014
Footpad infection of C3HeB/FeJ mice with Leishmania amazonensis leads to chronic lesions accompanied by large parasite loads. Co-infecting these animals with L.
Katherine N Gibson-Corley, Marie M Bockenstedt, Huijuan Li, Paola M Boggiatto, Yashdeep Phanse, Christine A Petersen, Bryan H Bellaire, Douglas E Jones   +7 more
doaj   +1 more source

Immune responses induced by a Leishmania (Leishmania) amazonensis recombinant antigen in mice and lymphocytes from vaccinated subjects

Revista do Instituto de Medicina Tropical de São Paulo, 1997
In the search for Leishmania recombinant antigens that can be used as a vaccine against American Cutaneous Leishmaniasis, we identified a Leishmania (Leishmania) amazonensis recombinant protein of 33 kD (Larp33) which is recognized by antibodies and ...
Ana Paula FERNANDES, Elizabeth Cortez HERRERA, Wilson MAYRINK, Ricardo T. GAZZINELLI, Wen Yu LIU, Carlos Alberto da COSTA, Carlos Alberto Pereira TAVARES, Maria Norma MELO, Marilene Susan Marques MICHALICK, Reiner GENTZ, Evaldo NASCIMENTO   +10 more
doaj   +1 more source

Proteomic Analysis Reveals a Predominant NFE2L2 (NRF2) Signature in Canonical Pathway and Upstream Regulator Analysis of Leishmania-Infected Macrophages

Frontiers in Immunology, 2019
CBA mice macrophages (MØ) control infection by Leishmania major and are susceptive to Leishmania amazonensis, suggesting that both parasite species induce distinct responses that play important roles in infection outcome.
Juliana Perrone Bezerra de Menezes, Ricardo Khouri, Ricardo Khouri, Camila Victoria Sousa Oliveira, Antonio Luis de Oliveira Almeida Petersen, Tais Fontoura de Almeida, Tais Fontoura de Almeida, Flávia R. L. Mendes, Amanda do Amor Divino Rebouças, Amanda Lopes Lorentz, Nívea Farias Luz, Jonilson Berlink Lima, Pablo Ivan Pereira Ramos, Rodrigo Pedro Soares, Jeronimo Nunes Rugani, Gregory A. Buck, Marco Aurélio Krieger, Fabrício Klerynton Marchini, Áislan de Carvalho Vivarini, Ulisses Gazos Lopes, Valéria de Matos Borges, Patricia Sampaio Tavares Veras, Patricia Sampaio Tavares Veras   +22 more
doaj   +1 more source

Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice

Iranian Journal of Parasitology, 2021
Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice.
Herintha Coeto Neitzke-Abreu, Rhuan Carlos Souza Caetano, Kárin Rosi Reinhold-Castro, Manoel Sebastião da Costa Lima-Junior, Wagner José Tenório dos Santos, Gessilda de Alcantara Nogueira de Melo, Roberto Kenji Nakamura Cuman, Sandra Mara Alessi Aristides, Thais Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni   +9 more
doaj  

KA activity against L. (L.) amazonensis in vitro.

, 2014
(A) Growth curve of L. (L.) amazonensis promastigotes treated with different KA concentrations (B) Growth curve of L. (L.) amazonensis promastigotes treated with glucantime® (GLU).
Antonio Sérgio C. Carvalho (534030), Edilene O. Silva (534033), Alberdan S. Santos (534031), Ana Paula D. Rodrigues (534028), Luis Henrique S. Farias (534029), José Luiz M. do Nascimento (534032)   +5 more
core   +1 more source

Leishmania amazonensis-Induced cAMP Triggered by Adenosine A2B Receptor Is Important to Inhibit Dendritic Cell Activation and Evade Immune Response in Infected Mice

Frontiers in Immunology, 2017
Differently from others Leishmania species, infection by the protozoan parasite L. amazonensis is associated with a lack of antigen-specific T-cell responses.
Amanda Braga Figueiredo, Míriam Conceição Souza-Testasicca, Míriam Conceição Souza-Testasicca, Tiago Wilson Patriarca Mineo, Luís Carlos Crocco Afonso   +4 more
doaj   +1 more source

Light microscopy and immunofluorescence of neutrophils co-cultured with L. (L.) amazonensis-infected macrophages.

, 2013
L. (L.) amazonensis-infected macrophages were either cultured in the absence (upper sequence) or in the presence of inflammatory neutrophils (lower sequence). After 4 days the cultures were stained with HE (A, E) or DAPI (C, G) or incubated with a rabbit
Clara Lúcia Barbiéri (299928), Érico Vinícius de Souza Carmo (360103), Simone Katz (299923)   +2 more
core   +1 more source