Results 41 to 50 of about 6,477 (171)

Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice

Iranian Journal of Parasitology, 2021
Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice.
Herintha Coeto Neitzke-Abreu, Rhuan Carlos Souza Caetano, Kárin Rosi Reinhold-Castro, Manoel Sebastião da Costa Lima-Junior, Wagner José Tenório dos Santos, Gessilda de Alcantara Nogueira de Melo, Roberto Kenji Nakamura Cuman, Sandra Mara Alessi Aristides, Thais Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni   +9 more
doaj  

Sphingolipid degradation in Leishmania (Leishmania) amazonensis.

PLoS Neglected Tropical Diseases, 2012
BackgroundHuman leishmaniasis is caused by more than 20 Leishmania species and has a wide range of symptoms. Our recent studies have demonstrated the essential role of sphingolipid degradation in the virulence of Leishmania (Leishmania) major, a species ...
Agiesh Balakrishna Pillai, Wei Xu, Ou Zhang, Kai Zhang   +3 more
doaj   +1 more source

Leishmania amazonensis-Induced cAMP Triggered by Adenosine A2B Receptor Is Important to Inhibit Dendritic Cell Activation and Evade Immune Response in Infected Mice

Frontiers in Immunology, 2017
Differently from others Leishmania species, infection by the protozoan parasite L. amazonensis is associated with a lack of antigen-specific T-cell responses.
Amanda Braga Figueiredo, Míriam Conceição Souza-Testasicca, Míriam Conceição Souza-Testasicca, Tiago Wilson Patriarca Mineo, Luís Carlos Crocco Afonso   +4 more
doaj   +1 more source

Extracellular matrix alterations in experimental murine Leishmania (L.) amazonensis infection

Parasitology, 2004
Here we describe extracellular matrix alterations in footpad lesions and draining lymph nodes caused by Leishmania (L.) amazonensis in mouse strains with distinct susceptibilities to this parasite: BALB/c (susceptible), C57BL/6 (intermediate), and DBA/2 (resistant).
A L, Abreu-Silva, K S, Calabrese, R A, Mortara, R C, Tedesco, F O, Cardoso, L O P, Carvalho, S C, Gonçalves da Costa   +6 more
openaire   +2 more sources

Histopathological and Molecular Data on Myxobolus spp. Infecting Bryconid Fish From the Brazilian Pantanal Wetland

Journal of Fish Diseases, EarlyView.
ABSTRACT Previous studies described Myxobolus umidus infecting the spleen of Brycon hilarii, whereas Myxobolus pantanalis and Myxobolus salminus infecting the gill filaments of Salminus brasiliensis. In this study, we provided supplementary morphological and molecular data on these three Myxobolus species and histopathological analyses of the tissues ...
Caroline Munhoz Meira, Milena Lucia Cornejo, Sarah Arana, Edson Aparecido Adriano, Antonio Augusto Mendes Maia   +4 more
wiley   +1 more source

Leishmania amazonensis promastigotes in 3D Collagen I culture: an in vitro physiological environment for the study of extracellular matrix and host cell interactions [PDF]

PeerJ, 2014
Leishmania amazonensis is the causative agent of American cutaneous leishmaniasis, an important neglected tropical disease. Once Leishmania amazonensis is inoculated into the human host, promastigotes are exposed to the extracellular matrix (ECM) of the ...
Debora B. Petropolis, Juliany C.F. Rodrigues, Nathan B. Viana, Bruno Pontes, Camila F.A. Pereira, Fernando C. Silva-Filho   +5 more
doaj   +2 more sources

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
Camila S. de Freitas, Eduardo Oliveira S. da Silva, Daniela C. Tristão, Guilherme M. Antar, Daniela P. Lage, Dóris M. Abrão, Luciana M. Ribeiro Antinarelli, Elaine S. Coimbra, João Henrique G. Lago, Eduardo A. F. Coelho   +9 more
wiley   +1 more source

Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Leishmania) amazonensis

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
Background Lipid metabolites play an important role in parasite differentiation and virulence. Studies have revealed that Leishmania sp. uses prostaglandins to evade innate barriers, thus enabling the parasites to survive inside immune cells. Despite the
Maria L. A. C. Bordon, Márcia D. Laurenti, Susan Pereira Ribeiro, Marcos H. Toyama, Daniela de O. Toyama, Luiz Felipe D. Passero   +5 more
doaj   +1 more source

Evaluation of Uliginosin B as a Modulator of the Ras Pathway: In Vivo Evidence From Caenorhabditis elegans and In Silico Insights

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
This study performs in vivo and in silico assays with uliginosin B, targeting its activity in the Ras signaling pathway, demonstrating a possible allosteric interaction with the HRAS (human) and LET‐60 (nematode) proteins, and a decrease in the overexpression of the let‐60 gene in the nematode C. elegans.
Maria Eduarda O. De Souza, Flávia Suelen De O. Pereira, Daniela Teixeira Rodrigues, Helder Dias Costa, Tarsila Dantas Da Rosa, Camila Machado Pires da Silva, Gilsane von Poser, Stela M. K. Rates, Favero R. Paula, Daiana Silva Ávila   +9 more
wiley   +1 more source

Innate Resistance to Leishmania amazonensis Infection in Rat Is Dependent on NOS2

Frontiers in Microbiology, 2021
Leishmania infection causes diverse clinical manifestations in humans. The disease outcome is complicated by the combination of many host and parasite factors.
Yun-Fu Chen, Si-Fei Yu, Chang-You Wu, Na Wu, Jia Shen, Juan Shen, Jiang-Mei Gao, Yan-Zi Wen, Geoff Hide, De-Hua Lai, Zhao-Rong Lun, Zhao-Rong Lun   +11 more
doaj   +1 more source