Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes. [PDF]
J Venom Anim Toxins Incl Trop Dis, 2019 Three drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal and hepatic toxicities. Therefore, the investigation of new compounds is required.
Mendonça DBD +7 more
europepmc +7 more sources
PLOS ONE, 2020 Leishmaniasis has been considered as emerging and re-emerging disease, and its increasing global incidence has raised concerns. The great clinical diversity of the disease is mainly determined by the species. In several American countries, tegumentary leishmaniasis (TL) is associated with both Leishmania amazonensis and L.
Bruna Soares de Souza Lima +7 more
openaire +4 more sources
The Expression of Mannose Receptors in Skin Fibroblast and Their Involvement in Leishmania (L.) amazonensis Invasion [PDF]
Journal of Histochemistry & Cytochemistry, 2005 Leishmania are protozoa that invade mononuclear phagocytes with the involvement of different ligand-receptor systems, including mannose receptors. Until now, scant data are available concerning the mechanisms that govern the infection of Leishmania in other host cell types such as fibroblasts.
Renata C, Hespanhol +4 more
openaire +3 more sources
Leishmania (L.) amazonensis-induced inhibition of nitric oxide synthesis in host macrophages [PDF]
Microbes and Infection, 2002 Inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production was demonstrated in J774-G8 macrophages infected with Leishmania (L.) amazonensis promastigotes. The downmodulation of NO production observed in infected and LPS-stimulated J774-G8 cells correlated with a reduction in inducible nitric oxide synthase (iNOS) activity.
Filomena M Perrella, Balestieri +5 more
openaire +2 more sources
Distinct Macrophage Fates after in vitro Infection with Different Species of Leishmania: Induction of Apoptosis by Leishmania (Leishmania) amazonensis, but Not by Leishmania (Viannia) guyanensis. [PDF]
PLoS ONE, 2015 Leishmania is an intracellular parasite in vertebrate hosts, including man. During infection, amastigotes replicate inside macrophages and are transmitted to healthy cells, leading to amplification of the infection.
Jarina Pena DaMata +6 more
doaj +1 more source
Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis. [PDF]
PLoS Pathogens, 2008 The intracellular protozoan Leishmania replicates in parasitophorous vacuoles (PV) that share many features with late endosomes/lysosomes. L. amazonensis PVs expand markedly during infections, but the impact of PV size on parasite intracellular survival ...
Jude Wilson +6 more
doaj +1 more source
PLOS ONE, 2015 Chemotherapy against visceral leishmaniasis is associated with high toxicity and drug resistance. Leishmania parasites are purine auxotrophs that obtain their purines from exogenous sources. Nucleoside hydrolases release purines from nucleosides and are drug targets for anti-leishmanial drugs, absent in mammal cells.
Elisangela Oliveira Freitas +8 more
openaire +4 more sources
Leishmania (L.) amazonensis peptidase activities inside the living cells and in their lysates
Molecular and Biochemical Parasitology, 2012 In this study we investigated the peptidase activity in Leishmania (L.) amazonensis live amastigote by confocal microscopy using peptidyl-MCA as substrates, the hydrolysis of which releases the MCA fluorophore inside the cells. Cell pre-treatment with peptidase inhibitors indicated the presence of cysteine and serine peptidases.
Caroselli, Elide E. +6 more
openaire +2 more sources
The role of TLR9 on Leishmania amazonensis infection and its influence on intranasal LaAg vaccine efficacy. [PDF]
PLoS Neglected Tropical Diseases, 2019 Leishmania (L.) amazonensis is one of the etiological agents of cutaneous leishmaniasis (CL) in Brazil. Currently, there is no vaccine approved for human use against leishmaniasis, although several vaccine preparations are in experimental stages.
Juliana Elena Silveira Pratti +14 more
doaj +1 more source
Metacaspase-binding peptide inhibits heat shock-induced death in Leishmania (L.) amazonensis. [PDF]
Cell Death Dis, 2017 AbstractLeishmania (Leishmania) amazonensis is an important agent of cutaneous leishmaniasis in Brazil. This parasite faces cell death in some situations during transmission to the vertebrate host, and this process seems to be dependent on the activity of metacaspase (MCA), an enzyme bearing trypsin-like activity present in protozoans, plants and fungi.
Peña MS +4 more
europepmc +4 more sources