Results 31 to 40 of about 6,477 (171)
PLOS ONE, 2015 Chemotherapy against visceral leishmaniasis is associated with high toxicity and drug resistance. Leishmania parasites are purine auxotrophs that obtain their purines from exogenous sources. Nucleoside hydrolases release purines from nucleosides and are drug targets for anti-leishmanial drugs, absent in mammal cells.
Elisangela Oliveira Freitas +8 more
openaire +4 more sources
The role of TLR9 on Leishmania amazonensis infection and its influence on intranasal LaAg vaccine efficacy. [PDF]
PLoS Neglected Tropical Diseases, 2019 Leishmania (L.) amazonensis is one of the etiological agents of cutaneous leishmaniasis (CL) in Brazil. Currently, there is no vaccine approved for human use against leishmaniasis, although several vaccine preparations are in experimental stages.
Juliana Elena Silveira Pratti +14 more
doaj +1 more source
Leishmania (L.) amazonensis peptidase activities inside the living cells and in their lysates
Molecular and Biochemical Parasitology, 2012 In this study we investigated the peptidase activity in Leishmania (L.) amazonensis live amastigote by confocal microscopy using peptidyl-MCA as substrates, the hydrolysis of which releases the MCA fluorophore inside the cells. Cell pre-treatment with peptidase inhibitors indicated the presence of cysteine and serine peptidases.
Caroselli, Elide E. +6 more
openaire +2 more sources
Kaurenoic Acid Possesses Leishmanicidal Activity by Triggering a NLRP12/IL-1β/cNOS/NO Pathway
Mediators of Inflammation, 2015 Leishmania amazonensis (L. amazonensis) infection can cause severe local and diffuse injuries in humans, a condition clinically known as American cutaneous leishmaniasis (ACL).
Milena Menegazzo Miranda +15 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2013 Leishmania parasites expose phosphatidylserine (PS) on their surface, a process that has been associated with regulation of host's immune responses.
Natalia Cadaxo Rochael +6 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 Leishmaniasis is an anthropozoonotic disease, and dogs are considered the main urban reservoir of the parasite. Macrophages, the target cells of Leishmania sp., play an important role during infection.
Natalia Rocha Nadaes +11 more
doaj +1 more source
Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages.
PLoS ONE, 2010 BackgroundStudies on the role of neutrophils in Leishmania infection were mainly performed with L. (L) major, whereas less information is available for L. (L) amazonensis.
Erico Vinícius de Souza Carmo +2 more
doaj +1 more source
An in vitro model of antibody-enhanced killing of the intracellular parasite Leishmania amazonensis. [PDF]
PLoS ONE, 2014 Footpad infection of C3HeB/FeJ mice with Leishmania amazonensis leads to chronic lesions accompanied by large parasite loads. Co-infecting these animals with L.
Katherine N Gibson-Corley +7 more
doaj +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 1997 In the search for Leishmania recombinant antigens that can be used as a vaccine against American Cutaneous Leishmaniasis, we identified a Leishmania (Leishmania) amazonensis recombinant protein of 33 kD (Larp33) which is recognized by antibodies and ...
Ana Paula FERNANDES +10 more
doaj +1 more source
Frontiers in Immunology, 2019 CBA mice macrophages (MØ) control infection by Leishmania major and are susceptive to Leishmania amazonensis, suggesting that both parasite species induce distinct responses that play important roles in infection outcome.
Juliana Perrone Bezerra de Menezes +22 more
doaj +1 more source