Results 151 to 160 of about 6,625 (182)

Subcellular localization of an extracellular serine protease in Leishmania (Leishmania) amazonensis

Parasitology Research, 2004
Extracellular proteolytic activity was detected in a Leishmania ( L.) amazonensis culture supernatant and a 56-kDa protein was purified using (NH4)2SO4 precipitation followed by affinity chromatography on aprotinin-agarose. A rabbit serum obtained against the 56-kDa extracellular serine protease was used in order to analyze its location in L.
R E, Silva-Lopez, J A, Morgado-Díaz, C R, Alves, S, Côrte-Real, S, Giovanni-De-Simone   +4 more
openaire   +2 more sources

EFFECT OF HYPOXIA ON MACROPHAGE INFECTION BY LEISHMANIA AMAZONENSIS

Journal of Parasitology, 2004
In the present study, we compared the effect of 5% oxygen tension (hypoxia) with a normal tension of 21% oxygen (normoxia) on macrophage infection by the protozoan parasite Leishmania amazonensis. Macrophages from different sources (human cell line U937, murine cell line J774, and murine peritoneal macrophages) exposed to hypoxia showed a reduction of ...
Marcelle Carolina, Colhone, Wagner Welber, Arrais-Silva, Claudia, Picoli, Selma, Giorgio   +3 more
openaire   +2 more sources

In vivo activity of perifosine against Leishmania amazonensis

Acta Tropica, 2008
Miltefosine has been established as the first oral administration drug against cutaneous and visceral leishmaniasis. Other alkyl-phospholipids such as edelfosine have been tested against Leishmania showing an in vitro antiparasitic activity. Perifosine in vitro activity has been previously demonstrated against different Leishmania species including ...
M Gabriela, Cabrera-Serra, Basilio, Valladares, Jose E, Piñero   +2 more
openaire   +2 more sources

Antileishmanial Activity of Azitahromycin Against Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) chagasi

The American Journal of Tropical Medicine and Hygiene, 2008
Azithromycin, an azalide antibiotic, is highly concentrated within different phagocytic cells, especially macrophages. The potential antileishmanial activity of azithromycin against three species of Leishmania from the New World was assessed using in vitro models.
Fernanda, de Oliveira-Silva, Eliane, de Morais-Teixeira, Ana, Rabello   +2 more
openaire   +2 more sources

Leishmania amazonensis: Characterization of an ecto-pyrophosphatase activity

Experimental Parasitology, 2014
Several ecto-enzymatic activities have been described in the plasma membrane of the protozoan Leishmania amazonensis, which is the major etiological agent of diffuse cutaneous leishmaniasis in South America. These enzymes, including ecto-phosphatases, contribute to the survival of the parasite by participating in phosphate metabolism.
Anita Leocadio, Freitas-Mesquita, André Luiz, Fonseca-de-Souza, José Roberto, Meyer-Fernandes   +2 more
openaire   +2 more sources

Apparent isocitrate lyase activity in Leishmania amazonensis

Acta Parasitologica, 2017
AbstractEarly reports have demonstrated the occurrence of glyoxylate cycle enzymes in ...
Concepción, Hernández-Chinea, Laura, Maimone, Yelitza, Campos, Walter, Mosca, Pedro J, Romero   +4 more
openaire   +2 more sources

Eosinophil chemotactic activity in Leishmania amazonensis promastigotes

Parasitology Research, 1996
Tissue eosinophilia was observed in the subcutaneous tissue of mice shortly after their inoculation not only with living but also with lysed promastigotes of Leishmania amazonensis. Intraperitoneal inoculation of lysed promastigotes from five different Leishmania species (L. donovani, L. chagasi, L. tropica, L. amazonensis, and L. braziliensis) induced
S, Saito, A, Hamada, N, Watanabe, T, Obata, K, Katakura, H, Ohtomo   +5 more
openaire   +2 more sources

Effect of Brazilian copaiba oils on Leishmania amazonensis

Journal of Ethnopharmacology, 2008
Copaiba oil has been used in folk medicine since the 19th century. The use of copaiba oils to treat leishmaniasis is cited in several ethnopharmacological studies. Nevertheless, the potential antileishmania of copaiba oils had not been studied.Eight different kinds of Brazilian copaiba oils were screened for antileishmanial activity.The ...
Adriana O, Santos, Tânia, Ueda-Nakamura, Benedito P, Dias Filho, Valdir F, Veiga Junior, Angelo C, Pinto, Celso Vataru, Nakamura   +5 more
openaire   +2 more sources

Active Transport of Glutamate in Leishmania (Leishmania) amazonensis

Journal of Eukaryotic Microbiology, 2008
ABSTRACT. Leishmania spp. are the causative agents of leishmaniasis, a complex of diseases with a broad spectrum of clinical manifestations. Leishmania (Leishmania) amazonensis is a main etiological agent of diffuse cutaneous leishmaniasis. Leishmania spp., as other trypanosomatids, possess a metabolism based significantly on the consumption of amino
Lisvane S, Paes, Robert L, Galvez Rojas, Anissa, Daliry, Lucile M, Floeter-Winter, Marcel I, Ramirez, Ariel M, Silber   +5 more
openaire   +2 more sources

Identification of N-acetylspermidine in Leishmania amazonensis

Molecular and Biochemical Parasitology, 1996
M, Rojas-Chaves, C, Hellmund, R D, Walter   +2 more
openaire   +2 more sources