Results 131 to 140 of about 6,625 (182)

<i>In vitro</i> and <i>in vivo</i> study of the inhibition of ubiquinone biosynthesis in <i>Leishmania (Leishmania) amazonensis</i> using the combination of buparvaquone and 4-nitrobenzoate as a strategy for the discovery of new therapeutic targets. [PDF]

Antimicrob Agents Chemother
Mesquita JT, Moura GC, Cavalcante T, Yokoyama Yasunaka JKU, Peres MA, Blanes Angeli C, Taniwaki NN, Simonsen Stolf B, Palmisano G, Katzin AM.   +9 more
europepmc   +1 more source

Epoxy-a-lapachone in nanosystem: a prototype drug for leishmaniasis assessed in the binomial BALB/c - Leishmania (Leishmania) amazonensis. [PDF]

Mem Inst Oswaldo Cruz
Peixoto JF, Gonçalves-Oliveira LF, Dias-Lopes G, Souza-Silva F, Alves CR.   +4 more
europepmc   +1 more source

Thermodynamic Determinants in Antibody-Free Nucleic Acid Lateral Flow Assays (AF-NALFA): Lessons from Molecular Detection of <i>Listeria monocytogenes</i>, <i>Mycobacterium leprae</i> and <i>Leishmania amazonensis</i>. [PDF]

Biomolecules
Lopes-Luz L, Neddermeyer PC, Sampaio GC, Alves LM, Fogaça MBT, Saavedra DP, Stefani MMA, Bührer-Sékula S.   +7 more
europepmc   +1 more source

Enhancing Antileishmanial Activity of Amidoxime-Based Compounds Bearing a 4,5-Dihydrofuran Scaffold: In Vitro Screening Against Leishmania amazonensis. [PDF]

Molecules
Maia Santos Urbancg Moncorvo F, Avendaño Leon OL, Curti C, Kabri Y, Redon S, Torres-Santos EC, Vanelle P.   +6 more
europepmc   +1 more source

Amphotericin B resistance in Leishmania amazonensis: In vitro and in vivo characterization of a Brazilian clinical isolate. [PDF]

PLoS Negl Trop Dis
Ferreira BA, Coser EM, de la Roca S, Aoki JI, Branco N, Soares GHC, Lima MIS, Coelho AC.   +7 more
europepmc   +1 more source

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In vitro activity of cinnamaldehyde on Leishmania (Leishmania) amazonensis

Experimental Parasitology, 2022
Tegumentary leishmaniasis is an endemic disease that urgently needs new and effective treatments. L. amazonensis is one of the main species involved in the transmission of this infectious and non-contagious disease. The currently available treatments for leishmaniasis have high toxicity and vary in efficacy.
Aline Ávila Brustolin, Áquila Carolina Fernandes Herculano Ramos-Milaré, Tatiane França Perles de Mello, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Thaís Gomes Verzignassi Silveira   +5 more
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Leishmania amazonensis response to artemisinin and derivatives

Parasitology International, 2021
The worldwide presence of Leishmania parasites increases in the poorest regions. Current leishmaniasis treatments are unsatisfactory due to resistance development, side effects and cost. Herein, we describe the in vitro activity of artemisinin (ART), artemether (ATM), artesunate (ATS) and dihydroartemisinin (DHA) against Leishmania amazonensis ...
Laura, Machín, Rachel, Nápoles, Lars, Gille, Lianet, Monzote   +3 more
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Characterization of Leishmania (Leishmania) amazonensis promastigotes resistant to pentamidine

Experimental Parasitology, 2008
Pentamidine is a second-line agent used in the treatment of leishmaniasis and its mode of action and mechanism of resistance is not well understood. It was previously demonstrated that transfection of promastigotes and amastigotes with the ABC transporter PRP1 gene confers resistance to pentamidine.
Adriano C, Coelho, Luciana G, Gentil, José Franco, da Silveira, Paulo C, Cotrim   +3 more
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Biochemical characterization of serine transport in Leishmania (Leishmania) amazonensis

Molecular and Biochemical Parasitology, 2009
In addition to its role as a protein component in Leishmania, serine is also a precursor for the synthesis of both phosphatidylserine, which is a membrane molecule involved in parasite invasion and inactivation of macrophages, and sphingolipids, which are necessary for Leishmania to differentiate into its infective forms.
Marcos Gonzaga, dos Santos, Lisvane Silva, Paes, Ricardo Andrade, Zampieri, Maria Fernanda Laranjeira, da Silva, Ariel Mariano, Silber, Lucile Maria, Floeter-Winter   +5 more
openaire   +2 more sources