Results 61 to 70 of about 6,322 (182)

Capacidad infectiva de promastigotes en fase estacionaria de leishmania (viannia) braziliensis y leishmania (viannia) peruviana, en línea celular dh82

Revista Peruana de Medicina Experimental y Salud Pública
Objetivos. Determinar la capacidad infectiva de los promastigotes de Leishmania (V.) peruviana y Leishmania (V.) braziliensis en la línea celular macrófago-monocítica de Canis familiaris DH82. Materiales y métodos.
Karen Daphne Calvay-Sánchez, Nyshon Máximo Rojas-Palomino, Aidé Clorinda Sandoval-Juarez, Alberto Cisneros-Tarmeño, Cristian Obregón-Cahuaya, Gloria Sonia Minaya-Gómez   +5 more
doaj   +2 more sources

In Situ Evaluation of Macrophage Populations and Inflammasome Components in Cutaneous and Mucocutaneous Leishmaniasis

Parasite Immunology, Volume 47, Issue 9, September 2025.
ABSTRACT American tegumentary leishmaniasis (ATL) affects the skin and mucous membranes, with a spectrum shaped by Th1/Th2 responses. This study investigated inflammasome activation in correlation with macrophage subpopulations, tissue parasitism, and histological changes in cutaneous and mucocutaneous leishmaniasis. We assessed inflammasome activation,
Caroline de Heleno Chagas de Carvalho, Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Vania Lucia da Ribeiro da Matta, Carolina de Esteves de Morais, Ricardo Romiti, Walter Belda Júnior, Márcia Dalastra Laurenti   +7 more
wiley   +1 more source

IL‐12 and IFN‐γ in Response to Leishmania Infantum Antigens in Felines From an Endemic Area for Visceral Leishmaniasis

Parasite Immunology, Volume 47, Issue 8, August 2025.
ABSTRACT Visceral leishmaniasis is a potentially fatal zoonosis with an increasing incidence. Most infected felines present the disease in its subclinical form and demonstrate greater resistance to parasitemia than dogs. However, the role of cellular immunity in felines is still poorly understood. This study measured serum levels of interleukin (IL)‐12
João Victor Lé Lode, Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Valéria Marçal Felix de Lima   +3 more
wiley   +1 more source

Leishmania (Viannia) braziliensis type 2 as probable etiological agent of canine cutaneous leishmaniasis in Brazilian Amazon.

PLoS ONE, 2019
Canine cutaneous leishmaniasis (CCL) is a zoonosis of public health interest, and in the Americas, Leishmania (Viannia) braziliensis has been identified as the main etiological agent. The present study sought to investigate Leishmania spp.
Andreia Fernandes Brilhante, Luciana Lima, Ricardo Andrade Zampieri, Vânia Lúcia Brandão Nunes, Maria Elizabeth Cavalheiros Dorval, Patrícia Fernandes Nunes da Silva Malavazi, Leonardo Augusto Kohara Melchior, Edna Aoba Yassui Ishikawa, Cristiane de Oliveira Cardoso, Lucile Maria Floeter-Winter, Marta Maria Geraldes Teixeira, Eunice Aparecida Bianchi Galati   +11 more
doaj   +1 more source

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Assessment of PCR in the detection of Leishmania spp in experimentally infected individual phlebotomine sandflies (Diptera: Psychodidae: Phlebotominae)

Revista do Instituto de Medicina Tropical de São Paulo, 2002
DNA amplification by the polymerase chain reaction (PCR) was applied in the investigation of the presence of Leishmania (Kinetoplastida: Trypanosomatidae) parasites in single phlebotomine sandflies.
MICHALSKY Érika M., FORTES-DIAS Consuelo L., PIMENTA Paulo F.P., SECUNDINO Nágila F.C., DIAS Edelberto S.   +4 more
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Unveiling the Kinomes of Leishmania infantum and L. braziliensis Empowers the Discovery of New Kinase Targets and Antileishmanial Compounds

Computational and Structural Biotechnology Journal, 2019
Leishmaniasis is a neglected tropical disease caused by parasites of the genus Leishmania (NTD) endemic in 98 countries. Although some drugs are available, current treatments deal with issues such as toxicity, low efficacy, and emergence of resistance ...
Joyce V.B. Borba, Arthur C. Silva, Pablo I.P. Ramos, Nathalia Grazzia, Danilo C. Miguel, Eugene N. Muratov, Nicholas Furnham, Carolina H. Andrade   +7 more
doaj   +1 more source

Dogs as Reservoirs forLeishmania braziliensis

Emerging Infectious Diseases, 2011
To the Editor: I have read the review by Sousa and Pearson (1), which provides a fascinating historical account of the Great Drought and the smallpox epidemic of the 1870s and their association with the emergence of cutaneous leishmaniasis in Ceara, Brazil.
openaire   +2 more sources

Leishmania (Viannia) braziliensis Inositol Phosphorylceramide: Distinctive Sphingoid Base Composition

Frontiers in Microbiology, 2017
Inositol phosphorylceramide (IPC), the major sphingolipid in the genus Leishmania but not found in mammals, is considered a potentially useful target for chemotherapy against leishmaniasis.
Erica V. De Castro Levatti, Marcos S. Toledo, Renata Watanabe Costa, Diana Bahia, Diana Bahia, Renato A. Mortara, Helio K. Takahashi, Anita H. Straus   +7 more
doaj   +1 more source

Secuencia parcial del genoma del maxicírculo de Leishmania braziliensis, comparación con otros tripanosomátidos

Universitas Scientiarum, 2011
Maxicircle genome partial sequence of Leishmania braziliensis: assembling and comparison with other trypanosomatids. Objective.With the aim to provide new insights for genotyping and phylogenetic studies of the Leishmania genus, in this study the ...
Paola Andrea Nocua Martinez, Cesar Augusto Ramírez Segura, José María Requena Rolania, Concepción Judith Puerta Bula   +3 more
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