Results 71 to 80 of about 6,448 (180)

Unveiling the Kinomes of Leishmania infantum and L. braziliensis Empowers the Discovery of New Kinase Targets and Antileishmanial Compounds

Computational and Structural Biotechnology Journal, 2019
Leishmaniasis is a neglected tropical disease caused by parasites of the genus Leishmania (NTD) endemic in 98 countries. Although some drugs are available, current treatments deal with issues such as toxicity, low efficacy, and emergence of resistance ...
Joyce V.B. Borba, Arthur C. Silva, Pablo I.P. Ramos, Nathalia Grazzia, Danilo C. Miguel, Eugene N. Muratov, Nicholas Furnham, Carolina H. Andrade   +7 more
doaj   +1 more source

Heterogeneity of cysteine proteinases in Leishmania braziliensis and Leishmania major.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 1994
Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with acrylamide copolymerized with gelatin (substrate-SDS-PAGE) was used to compare promastigote proteinases from two Leishmania species (L. braziliensis and L. major-like). Substrate-SDS-PAGE resolved at least 6 distinct proteinase activities with relative molecular masses between 20
C R, Alves, M C, Marzochi, S, Giovanni-de-Simone   +2 more
openaire   +2 more sources

Secuencia parcial del genoma del maxicírculo de Leishmania braziliensis, comparación con otros tripanosomátidos

Universitas Scientiarum, 2011
Maxicircle genome partial sequence of Leishmania braziliensis: assembling and comparison with other trypanosomatids. Objective.With the aim to provide new insights for genotyping and phylogenetic studies of the Leishmania genus, in this study the ...
Paola Andrea Nocua Martinez, Cesar Augusto Ramírez Segura, José María Requena Rolania, Concepción Judith Puerta Bula   +3 more
doaj  

Leishmania (Viannia) braziliensis Inositol Phosphorylceramide: Distinctive Sphingoid Base Composition

Frontiers in Microbiology, 2017
Inositol phosphorylceramide (IPC), the major sphingolipid in the genus Leishmania but not found in mammals, is considered a potentially useful target for chemotherapy against leishmaniasis.
Erica V. De Castro Levatti, Marcos S. Toledo, Renata Watanabe Costa, Diana Bahia, Diana Bahia, Renato A. Mortara, Helio K. Takahashi, Anita H. Straus   +7 more
doaj   +1 more source

Attempts using cryotherapy to achieve more rapid healing in patients with cutaneous leishmaniasis due to L. braziliensis braziliensis

Revista da Sociedade Brasileira de Medicina Tropical, 1983
The use of cryotherapy as an adjunct to systemic antimonial therapy (Clucantime) was studied in 17 patients with a total of23 skin lesions of leishmaniasis in an area where L. braziliensis braziliensis is the species in circulation.
Elmer Alejandro Llanos Cuentas, Philip Davis Marsden, Douglas Torre, Air Colombo Barreto   +3 more
doaj  

Modulation of fibroblast behavior by Leishmania: a pathway to understanding disease progression in cutaneous leishmaniasis

BMC Microbiology
Leishmaniasis is a parasitic infection caused by obligatory intracellular protozoa of the Leishmania genus. Macrophages are the main cell for Leishmania parasites that play a key role in immune response against it.
Tarcisio Navegante de Queiroz Filho, Brenda Furtado Costa, Ana Paula Drummond Rodrigues   +2 more
doaj   +1 more source

Molecular diagnosis of cutaneous leishmaniasis in an endemic area of Acre State in the Amazonian Region of Brazil

Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION This study proposes to identify the Leishmania species found in the skin lesions of cutaneous leishmaniasis (CL) patients from Brasiléia municipality (Acre).
Thais de Araujo-Pereira, Daniela de Pita-Pereira, Regina Barbosa Moreira, Tainah Silva-Galdino, Márcia P. de Oliveira Duarte, Reginaldo Peçanha Brazil, Constança Britto   +6 more
doaj   +1 more source

Achievement of constitutive fluorescent pLEXSY-egfp Leishmania braziliensis and its application as an alternative method for drug screening in vitro

Memorias do Instituto Oswaldo Cruz
BACKGROUND Gene reporter-fluorescent cells have emerged as alternative method for drug screening. OBJECTIVE Achievement of constitutive expression of fluorescent protein GFP by Leishmania braziliensis as alternative method for drug screening. METHODS
Matheus Silva e Bastos, Luciana Ângelo de Souza, Thiago Souza Onofre, Abelardo Silva Júnior, Márcia Rogéria de Almeida, Gustavo Costa Bressan, Juliana Lopes Rangel Fietto   +6 more
doaj   +1 more source

Leishmania braziliensis exosomes activate human macrophages to produce proinflammatory mediators. [PDF]

Front Immunol, 2023
Peixoto FC, Zanette DL, Cardoso TM, Nascimento MT, Sanches RCO, Aoki M, Scott P, Oliveira SC, Carvalho EM, Carvalho LP.   +9 more
europepmc   +1 more source

Leishmaniose cutânea na Amazônia: registro do primeiro caso humano de infecção mista, determinado por duas espécies distintas de Leishmnias: Leishmania brasiliensis e Leishmania mexicana amazonensis Cutaneous leishmaniasis in Amazonia: the first record of a case of cutaneous leishmaniasis caused by two different parasites: Leishmania braziliensis braziliensis and Leishmania mexicana amazonensis

Revista do Instituto de Medicina Tropical de São Paulo, 1984
Fez-se o registro, na Amazônia, do primeiro caso humano de infecção cutânea mista determinada por duas espécies distintas de Leishmania: a Leishmania braziliensis braziliensis e a Leishmania mexicana amazonensis.
F. T. Silveira, R. Lainson, J. J. Shaw, R. da S. M. Ribeiro   +3 more
doaj