Results 51 to 60 of about 10,019 (209)

Pterocarpanquinone LQB-118 induces apoptosis in Leishmania (Viannia) braziliensis and controls lesions in infected hamsters. [PDF]

PLoS ONE, 2014
Previous results demonstrate that the hybrid synthetic pterocarpanquinone LQB-118 presents antileishmanial activity against Leishmania amazonensis in a mouse model.
Luciana Costa, Roberta O Pinheiro, Patrícia M L Dutra, Rosiane F Santos, Edézio F Cunha-Júnior, Eduardo C Torres-Santos, Alcides J M da Silva, Paulo R R Costa, Silvia A G Da-Silva   +8 more
doaj   +1 more source

Sclerosing Orbital Inflammation Caused by Leishmania braziliensis [PDF]

The American Society of Tropical Medicine and Hygiene, 2017
Orbital biopsy of nonspecific orbital inflammation, commonly referred to as “orbital pseudotumor,” typically shows a combination of polyclonal lymphocytes, plasmocytes, leukocytes, macrophages, and variable degrees of collagen deposition. Herein, we report a patient with a positive history of mucocutaneous leishmaniasis who presented with an orbital ...
Antonio Augusto V, Cruz, Eliza V C, Alves-Ferreira, Gherusa, Milbratz-Moré, Fernando, Chahud, Patricia C, Ruy, Maria Irma Seixas, Duarte, Angela Kaysel, Cruz   +6 more
openaire   +2 more sources

Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice

Iranian Journal of Parasitology, 2021
Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice.
Herintha Coeto Neitzke-Abreu, Rhuan Carlos Souza Caetano, Kárin Rosi Reinhold-Castro, Manoel Sebastião da Costa Lima-Junior, Wagner José Tenório dos Santos, Gessilda de Alcantara Nogueira de Melo, Roberto Kenji Nakamura Cuman, Sandra Mara Alessi Aristides, Thais Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni   +9 more
doaj  

Pioglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, Downregulates the Inflammatory Response in Cutaneous Leishmaniasis Patients Without Interfering in Leishmania braziliensis Killing by Monocytes

Frontiers in Cellular and Infection Microbiology, 2022
Patients with cutaneous leishmaniasis (CL) due to Leishmania braziliensis infection have an exacerbated inflammatory response associated with tissue damage and ulcer development.
Maurício T. Nascimento, Maurício T. Nascimento, Maurício T. Nascimento, Ravena S. O. Cordeiro, Cayo Abreu, Camila P. Santos, Camila P. Santos, Fábio Peixoto, Fábio Peixoto, Gabriela A. Duarte, Thiago Cardoso, Thiago Cardoso, Camila I. de Oliveira, Camila I. de Oliveira, Camila I. de Oliveira, Edgar M. Carvalho, Edgar M. Carvalho, Edgar M. Carvalho, Edgar M. Carvalho, Lucas P. Carvalho, Lucas P. Carvalho, Lucas P. Carvalho, Lucas P. Carvalho   +22 more
doaj   +1 more source

Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira, L. da Silva Lara, S. da Costa Lanera, T. Pérez de Souza, M. C. de Souza Pereira, G. L. Delogu, M. Silva dos Santos, M. J. Matos   +7 more
wiley   +1 more source

Treatment of canine cutaneous leishmaniasis by Leishmania (Viannia) braziliensis in dogs with furazolidone and β-cyclodextrin: case report.

Veterinaria Italiana, 2023
Euthanasia of animals is not accepted as a control for cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis and drugs used in humans for the treatment of leishmaniasis are not allowed for animals in Brazil.
Marcos Santos Zanini, Larissa Ataíde Siqueira, Yuri Vieira Almeida, Laisa Savergnini Poleze, Dante Gnecco Zanini , Roberto Ramos Sobreira, Ana Paula Madureira   +6 more
doaj   +1 more source

Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in the neglected tropical ...
Priyanka Bose, Irit Dahan, Alexander Upcher, Ran Zalk, Iris Grossman‐Haham   +4 more
wiley   +1 more source

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira, Ellen Dyminski Parente Ribeiro, Otávio Henrique Pradi Guenther, Fernanda Tomiotto‐Pellissier   +3 more
wiley   +1 more source

Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms [PDF]

, 1992
A new method is described which has made possible the long-term axenic cultivation of Leishmania mexicana amastigote-like forms in Schneider's Drosophila medium supplemented with 20% (v/v) foetal calf serum.
Coombs, G H, Robertson, C D, Tetley, L, Bates, P A   +3 more
core  

Conflict and kala-azar: determinants of adverse outcomes of kala-azar among patients in southern Sudan.

, 2004
We analyzed data obtained from 3365 patients with kala-azar (KA) or post-KA dermal leishmaniasis (PKDL) treated by Medecins Sans Frontieres-Holland in south Sudan from October 1998-May 2002. Patients were malnourished (median body mass index [BMI], 15.5;
Keus, Kees, Melaku, Y, Davies, Clive, Melaku, Yosef, Kipngetich, Sammy, Keus, K, Davidson, R, Kipngetich, S, Ritmeijer, Koert, Collin, Simon, Davidson, Robert, Collin, S, Ritmeijer, K, Davies, C   +13 more
core   +1 more source