Results 101 to 110 of about 30,974 (225)

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Targeting Aurora Kinases as Essential Cell‐Cycle Regulators to Deliver Multi‐Stage Antimalarials Against Plasmodium Falciparum

Angewandte Chemie, Volume 137, Issue 51, December 15, 2025.
In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld, Keletso Maepa, Marché Maree, Jessica L. Thibaud, Nicolaas Salomane, Rosie Bridgwater, Mufuliat T. Famodimu, Luiz C. Godoy, Charisse Flerida A. Pasaje, Nonlawat Boonyalai, Mariana Laureano de Souza, Justin Fong, Tayla Rabie, Mariëtte van der Watt, Rensu P. Theart, Sonja Ghidelli‐Disse, Jacquin C. Niles, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael J. Delves, Kelly Chibale, Kathryn J. Wicht, Lauren B. Coulson, Lyn‐Marié Birkholtz   +23 more
wiley   +1 more source

The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference! [PDF]

, 2015
Kinetoplastids are unicellular, eukaryotic, flagellated protozoans containing the eponymous kinetoplast. Within this order, the family of trypanosomatids are responsible for some of the most serious human diseases, including Chagas disease (Trypanosoma ...
De Koning, Harry P., Kalejaiye, Titilola D., Tagoe, Daniel N. A.   +2 more
core   +1 more source

Can cutaneous leishmaniasis provoke a resurgence of kala-azar in the Indian subcontinent?

BMC Infectious Diseases
Background The ongoing kala-azar elimination program in Nepal is based on the assumption of anthroponotic transmission of the protozoan parasite Leishmania donovani. This parasite species was recently also found in lesions of cutaneous leishmaniasis (CL)
Narayan Raj Bhattarai, Keshav Rai, Surendra Uranw, Dhan Keshar Khadka, Basudha Khanal, Gokarna Dahal, Sushmita Pradhan, Sushil Dhakal, Pieter Monsieurs, Tanyth de Gooyer, Kristien Cloots, Epco Hasker, Gert Van der Auwera   +12 more
doaj   +1 more source

An arginine deprivation response pathway is induced in Leishmania during macrophage invasion [PDF]

, 2016
Amino acid sensing is an intracellular function that supports nutrient homeostasis, largely through controlled release of amino acids from lysosomal pools.
Balno, Caitlin, Bendelak, Keren, Ephros, Moshe, Goldman-Pinkovich, Adele, Jardim, Armando, Myler, Peter J, Rentsch, Doris, Strasser, Rona, Wiese, Martin, Zeituni-Molad, Michal, Zilberstein, Dan   +10 more
core   +3 more sources

Glycobiology of Leishmania donovani.

The Indian journal of medical research, 2006
Leishmania donovani, the causative organism of visceral leishmaniasis (VL) is one of the deadliest of the entire known Leishmania species. This protozoan parasite displays immense adaptability to survive under extremely harsh conditions. Cell surface glycoconjugates play a pivotal role in parasite virulence and infectivity.
Sumi, Mukhopadhyay, Chitra, Mandal
openaire   +1 more source

Noncovalent complexation of amphotericin-B with Poly(α-glutamic acid).

, 2013
A noncovalent complex of amphotericin B (AmB) and poly(α-glutamic acid) (PGA) was prepared to develop a safe and stable formulation for the treatment of leishmaniasis. The loading of AmB in the complex was in the range of ∼20-50%.
Brocchini, Stephen, Croft, Simon L, Les, Karolina A, Mohamed-Ahmed, Abeer HA, Seifert, Karin   +4 more
core   +1 more source

Risk factors of visceral leishmaniasis in East Africa: a case-control study in Pokot territory of Kenya and Uganda [PDF]

, 2007
BACKGROUND: In East Africa, visceral leishmaniasis (VL) is endemic in parts of Sudan, Ethiopia, Somalia, Kenya and Uganda. It is caused by Leishmania donovani and transmitted by the sandfly vector Phlebotomus martini.
A. Ocheng, AHLUWALIA, Alvar, Anoopa Sharma, BARNETT, Basimike, Bern, Bern, Boussery, Bucheton, Chappuis, Chappuis, D. T Worku, Elnaiem, Filmer, Gebre-Michael, Hamilton, Heisch, Iversen, J. H Kolaczinski, J. Kasimiro, Jahn, Mohamed, N. Kabatereine, Ngumbi, Perkins, R. Reithinger, RANJAN, Robert, RYAN, S. Brooker, Schaefer, Schenkel, Takken   +33 more
core   +3 more sources

Current Perspectives on Leishmaniasis

Journal of Gandaki Medical College, 2019
No abstract available.
KR Reddy
doaj   +1 more source

IL-4 contributes to failure, and colludes with IL-10 to exacerbate Leishmania donovani infection following administration of a subcutaneous leishmanial antigen vaccine [PDF]

, 2014
Visceral leishmaniasis caused by the protozoan parasite Leishmania donovani complex is a potentially fatal disease if left untreated. Few treatment options exist and are toxic, costly and ineffective against resistant strains.
Ali, Nahid, Bhowmick, Sudipta, Ravindran, Rajesh   +2 more
core   +3 more sources