Revista da Sociedade Brasileira de Medicina Tropical, 2002 Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals.
Wilson Mayrink +6 more
doaj +1 more source
Unveiling the Role of the Integrated Endoplasmic Reticulum Stress Response in Leishmania Infection - Future Perspectives. [PDF]
, 2016 The integrated endoplasmic reticulum stress response (IERSR) is an evolutionarily conserved adaptive mechanism that ensures endoplasmic reticulum (ER) homeostasis and cellular survival in the presence of stress including nutrient deprivation, hypoxia ...
Aktas, B.H. +5 more
core +1 more source
Frontiers in Microbiology, 2018 CBA mouse macrophages control Leishmania major infection yet are permissive to Leishmania amazonensis. Few studies have been conducted to assess the role played by autophagy in Leishmania infection.
Beatriz R. S. Dias +11 more
doaj +1 more source
Distinct Macrophage Fates after in vitro Infection with Different Species of Leishmania: Induction of Apoptosis by Leishmania (Leishmania) amazonensis, but Not by Leishmania (Viannia) guyanensis. [PDF]
PLoS ONE, 2015 Leishmania is an intracellular parasite in vertebrate hosts, including man. During infection, amastigotes replicate inside macrophages and are transmitted to healthy cells, leading to amplification of the infection.
Jarina Pena DaMata +6 more
doaj +1 more source
Antileishmanial activity of extracts from Libidibia ferrea: development of in vitro and in vivo tests [PDF]
Acta Amazonica, 2017 Treatment of cutaneous leishmaniasis (CL) is difficult due to the scarce number of drugs able to eliminate completely the intracellular form of the parasite.
Claudia Dantas COMANDOLLI-WYREPKOWSKI +9 more
doaj +2 more sources
Frontiers in Immunology, 2021 BackgroundLeishmaniasis is a neglected arthropod-borne disease that affects millions of people worldwide. Successful Leishmania infections require the mitigation of immune cell functions leading to parasite survival and proliferation.
Rafael Tiburcio +17 more
doaj +1 more source
Extracellular matrix alterations in experimental murine Leishmania (L.) amazonensis infection
Parasitology, 2004 Here we describe extracellular matrix alterations in footpad lesions and draining lymph nodes caused by Leishmania (L.) amazonensis in mouse strains with distinct susceptibilities to this parasite: BALB/c (susceptible), C57BL/6 (intermediate), and DBA/2 (resistant).
A L, Abreu-Silva +6 more
openaire +2 more sources
Microorganisms, 2021 Leishmania amazonensis parasites are etiological agents of cutaneous leishmaniasis in the New World. BALB/c mice are highly susceptible to L. amazonensis challenge due to their inability to mount parasite-dependent IFN-γ-mediated responses.
Manuel Soto +6 more
doaj +1 more source
Antiprotozoal activity of flavonoids from Eupatorium arnottianum [PDF]
, 2017 Dichloromethane and ethanol extracts of Eupatorium arnottianum were evaluated for invitroleishmanicidal activity. The dichloromethane extract produced 80% and 85% of growthinhibition on both Leishmania mexicana and Leishmania amazonensis promastigotes ...
Cazorla, Silvia Ines +7 more
core
Phage-fused epitopes from Leishmania infantum used as immunogenic vaccines confer partial protection against Leishmania amazonensis infection [PDF]
, 2016 Two mimotopes of Leishmania infantum identified by phage display were evaluated as vaccine candidates in BALB/c mice against Leishmania amazonensis infection.
Coelho, Eduardo A. F. +2 more
core +1 more source