Results 51 to 60 of about 8,781 (205)

Extracellular matrix alterations in experimental murine Leishmania (L.) amazonensis infection

Parasitology, 2004
Here we describe extracellular matrix alterations in footpad lesions and draining lymph nodes caused by Leishmania (L.) amazonensis in mouse strains with distinct susceptibilities to this parasite: BALB/c (susceptible), C57BL/6 (intermediate), and DBA/2 (resistant).
A L, Abreu-Silva, K S, Calabrese, R A, Mortara, R C, Tedesco, F O, Cardoso, L O P, Carvalho, S C, Gonçalves da Costa   +6 more
openaire   +2 more sources

Antileishmanial activity of extracts from Libidibia ferrea: development of in vitro and in vivo tests [PDF]

Acta Amazonica, 2017
Treatment of cutaneous leishmaniasis (CL) is difficult due to the scarce number of drugs able to eliminate completely the intracellular form of the parasite.
Claudia Dantas COMANDOLLI-WYREPKOWSKI, Bruno Bezerra JENSEN, Iryna GRAFOVA, Pierre Alexandre dos SANTOS, Angela Maria Comapa BARROS, Fabiane Veloso SOARES, José Fernando Marques BARCELLOS, Aline Fagundes da SILVA, Andriy GRAFOV, Antonia Maria Ramos FRANCO   +9 more
doaj   +2 more sources

DC-SIGN Mediates the Interaction Between Neutrophils and Leishmania amazonensis-Infected Dendritic Cells to Promote DC Maturation and Parasite Elimination

Frontiers in Immunology, 2021
BackgroundLeishmaniasis is a neglected arthropod-borne disease that affects millions of people worldwide. Successful Leishmania infections require the mitigation of immune cell functions leading to parasite survival and proliferation.
Rafael Tiburcio, Rafael Tiburcio, Léon Dimitri Melo, Léon Dimitri Melo, Sara Nunes, Sara Nunes, Ana Luísa Augusto Barbosa, Elaine Carvalho de Oliveira, Elaine Carvalho de Oliveira, Martha Suarez, Martha Suarez, Valéria M. Borges, Valéria M. Borges, Natalia Tavares, Natalia Tavares, Claudia Ida Brodskyn, Claudia Ida Brodskyn, Claudia Ida Brodskyn   +17 more
doaj   +1 more source

Multifunctional Oregano‐Derived Plasma Polymer Coatings for Wound Healing Applications: An In Vitro Study

International Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT Chronic wounds, exacerbated by infection, aging, diabetes, and oxidative stress, remain a significant challenge in clinical management and impose a substantial burden on healthcare systems. This study presents oregano‐derived plasma polymers (OPP) as a multifunctional surface coating for advanced wound healing applications.
Jesus Romo‐Rico, Neethu Ninan, Andrew Hayles, Smriti Murali Krishna, Krasimir Vasilev, Jonathan Golledge, Richard Bright, Mohan Jacob   +7 more
wiley   +1 more source

Effects of medicinal plant extracts on growth of Leishmania (L.) amazonensis and Trypanosoma cruzi [PDF]

Revista Brasileira de Ciências Farmacêuticas, 2005
This study describes the screening of extracts obtained from 19 species of plants used in Brazilian traditional medicine for treatment of a variety of diseases. The extracts were tested against axenic amastigote and promastigote forms of Leishmania (L.) amazonensis, and epimastigote forms of Trypanosoma cruzi in vitro at a concentration of 100 mg/ml ...
Luize, Patrícia Shima, Tiuman, Tatiana Shioji, Morello, Luis Gustavo, Maza, Paloma Korehiza, Ueda-Nakamura, Tânia, Dias Filho, Benedito Prado, Cortez, Diógenes Aparício Garcia, Mello, João Carlos Palazzo de, Nakamura, Celso Vataru   +8 more
openaire   +2 more sources

Desenvolvimento de um teste colorimétrico para triagem da atividade leishmanicida de compostos utilizando Leishmania amazonensis expressando a enzima beta-galactosidase [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-graduação em Biotecnologia e Biociências, Florianópolis, 2013No presente trabalho transfectamos uma cepa de Leishmania amazonensis com um plasmídeo contendo o gene da ...
Tonini, Maiko Luis
core  

Inoculation of the Leishmania infantum HSP70-II Null Mutant Induces Long-Term Protection against L. amazonensis Infection in BALB/c Mice

Microorganisms, 2021
Leishmania amazonensis parasites are etiological agents of cutaneous leishmaniasis in the New World. BALB/c mice are highly susceptible to L. amazonensis challenge due to their inability to mount parasite-dependent IFN-γ-mediated responses.
Manuel Soto, Laura Ramírez, José Carlos Solana, Emma C. L. Cook, Elena Hernández-García, José María Requena, Salvador Iborra   +6 more
doaj   +1 more source

Potential vectors of Leishmaniases in the Environmental Protection Area and Tinguá Federal Biological Reserve, Municipality of Nova Iguaçu, Rio de Janeiro, Brazil

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 246-259, June 2026.
This study was to describe the composition of sand fly fauna, detect potential vectors of Leishmania spp. in the Tinguá district, an ATL endemic, Rio de Janeiro, Brazil. Seven species of vectorial importance in the epidemiological cycle of leishmaniasis was observed: Nyssomyia intermedia, Migonemyia migonei, Pintomyia fischeri, Psychodopygus hirsutus ...
Antônio L. F. Santana, Alfredo C. R. Azevedo, Margarete M. S. Afonso, Bruno M. Carvalho, Vanessa R. Vieira, Simone M. Costa, Júlia S. Silva, Thais A. Pereira, Daniela P. Pereira, Maurício L. Vilela   +9 more
wiley   +1 more source

In vitro and in vivo activity of meglumine antimoniate produced at Farmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania) amazonensis, L (L.) chagasi and L (Viannia) braziliensis [PDF]

Memórias do Instituto Oswaldo Cruz, 2008
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fiocruz, Brazil (TAMs), was assessed and compared to Glucantime-Aventis Pharma Ltda. Using the amastigote-like in vitro model, the active concentrations of Sb v varied from 10microg/ml to 300microg/ml for L.
de Morais-Teixeira, Eliane, de Carvalho, Alcione S, da Costa, Jorge CS, Duarte, Silvio L, Mendonça, Jorge S, Boechat, Núbia, Rabello, Ana   +6 more
openaire   +4 more sources

In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195

Memorias do Instituto Oswaldo Cruz, 2018
BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in many countries, including Brazil. Currently available treatments require long-term use and have serious side effects, necessitating the development of new
Carlos Eduardo Sampaio Guedes, Beatriz Rocha Simões Dias, Antonio Luis de Oliveira Almeida Petersen, Kercia Pinheiro Cruz, Niara de Jesus Almeida, Daniela Rodrigues Andrade, Juliana Perrone Bezerra de Menezes, Valéria de Matos Borges, Patricia Sampaio Tavares Veras   +8 more
doaj   +1 more source