Results 51 to 60 of about 14,096,336 (162)

Exploring Biological Properties of Manganese(II)‐Phenanthroline‐Based Complexes: In Vitro Insights

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
Four Mn(II) complexes with phenanthroline derivatives were studied. These compounds were tested against several parasites and different human cancer cells. Despite its cytotoxicity on breast cancer, DNA seems not to be the main biological target. These complexes can drive the design and development of new metal‐based agents with improved biological ...
Roberto S. Silva, Marcos V. Palmeira‐Mello, Mikaelly P. Caet, Celisnolia M. Leite, Arieli B. Portugal, Pedro H. Machado, Alexandre B. Carvalho, Isabel Correia, Leonardo M. Moreira, Thatiana L. B. V. Simão, Elena Lasunskaia, Michelle F. Muzitano, José L. Nepomuceno‐Silva, João L. M. Wanderley, Javier Ellena, Alzir A. Batista, Mario S. Schultz   +16 more
wiley   +1 more source

Drosophila Model of Leishmania amazonensis Infection

, 2017
This protocol describes how to generate and harvest antibody-free L. amazonensis amastigotes, and how to infect adult Drosophila melanogaster with these parasites.
Kendi Okuda, Neal Silverman
core   +1 more source

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

Comparative two-dimensional gel electrophoresis maps for promastigotes of Leishmania amazonensis and Leishmania major

Brazilian Journal of Infectious Diseases
The outcome of Leishmania infections is determined by both the parasite species and the host genetic makeup. While much has been learned regarding immune responses to this parasite, our knowledge on parasite-derived factors is limited.
Reynolds K. B. Brobey, Fang C. Mei, Xiaodong Cheng, Lynn Soong   +3 more
doaj   +1 more source

Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages.

PLoS ONE, 2010
BackgroundStudies on the role of neutrophils in Leishmania infection were mainly performed with L. (L) major, whereas less information is available for L. (L) amazonensis.
Erico Vinícius de Souza Carmo, Simone Katz, Clara Lúcia Barbiéri   +2 more
doaj   +1 more source

Impairment of dendritic cell functions during in vitro Leishmania amazonensis infection [PDF]

, 2005
Leishmania major (L. major) is the most well-studied Leishmania species. Many classical studies on L. major have lead to the paradigm of Th1/Th2 dichotomy which has been a dogma in infectious disease research (137). Leishmania amazonensis (L. amazonensis)
Jie, Fei
core   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source

VAPA mediates lipid exchange between Leishmania amazonensis and host macrophages.

PLoS Pathogens
Leishmania is a vacuolar pathogen that replicates within parasitophorous vacuoles inside host phagocytes. To promote its replication, Leishmania relies on a panoply of strategies to acquire macromolecules such as lipids from host macrophages.
Ilona Gdovinova, Albert Descoteaux
doaj   +1 more source

Multifunctional Oregano‐Derived Plasma Polymer Coatings for Wound Healing Applications: An In Vitro Study

International Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT Chronic wounds, exacerbated by infection, aging, diabetes, and oxidative stress, remain a significant challenge in clinical management and impose a substantial burden on healthcare systems. This study presents oregano‐derived plasma polymers (OPP) as a multifunctional surface coating for advanced wound healing applications.
Jesus Romo‐Rico, Neethu Ninan, Andrew Hayles, Smriti Murali Krishna, Krasimir Vasilev, Jonathan Golledge, Richard Bright, Mohan Jacob   +7 more
wiley   +1 more source

Modulation of fibroblast behavior by Leishmania: a pathway to understanding disease progression in cutaneous leishmaniasis

BMC Microbiology
Leishmaniasis is a parasitic infection caused by obligatory intracellular protozoa of the Leishmania genus. Macrophages are the main cell for Leishmania parasites that play a key role in immune response against it.
Tarcisio Navegante de Queiroz Filho, Brenda Furtado Costa, Ana Paula Drummond Rodrigues   +2 more
doaj   +1 more source