Results 111 to 120 of about 10,324 (216)

In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195

Memorias do Instituto Oswaldo Cruz, 2018
BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in many countries, including Brazil. Currently available treatments require long-term use and have serious side effects, necessitating the development of new
Carlos Eduardo Sampaio Guedes, Beatriz Rocha Simões Dias, Antonio Luis de Oliveira Almeida Petersen, Kercia Pinheiro Cruz, Niara de Jesus Almeida, Daniela Rodrigues Andrade, Juliana Perrone Bezerra de Menezes, Valéria de Matos Borges, Patricia Sampaio Tavares Veras   +8 more
doaj   +1 more source

Clonagem e expressão da enzina tripanotiona redutase de Leishmania braziliensis e atividade leishmanicida de chalconas [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-graduação em Biotecnologia, Florianópolis, 2011O presente estudo teve por objetivo avaliar atividade leishmanicida in vitro de chalconas trimetoxiladas contra formas ...
Nunes, Rebeca Körting
core  

Modulation of fibroblast behavior by Leishmania: a pathway to understanding disease progression in cutaneous leishmaniasis

BMC Microbiology
Leishmaniasis is a parasitic infection caused by obligatory intracellular protozoa of the Leishmania genus. Macrophages are the main cell for Leishmania parasites that play a key role in immune response against it.
Tarcisio Navegante de Queiroz Filho, Brenda Furtado Costa, Ana Paula Drummond Rodrigues   +2 more
doaj   +1 more source

Evaluación del efecto del ácido nalidíxico, ampicilina, kanamicina, penicilina G y polimixina B en los cultivos de promastigotes de leishmania

Biomédica: revista del Instituto Nacional de Salud, 1992
Se evaluó el efecto de diferentes concentraciones de ácido nalidíxico, ampicilina, kanarnicina, penicilina G y polimixina B, sobre la población de promastigotes de Leishmania braziliensis braziliensis , Leishmania donovani chagasi y Leishmania mexicana ...
Sofía Duque Beltrán, Augusto Corredor Arjona, Marleny Montilla Moreno, Dioselina Peláez Carvajal   +3 more
doaj   +1 more source

Extracellular Vesicles Released by Leishmania (Leishmania) amazonensis Promastigotes with Distinct Virulence Profile Differently Modulate the Macrophage Functions. [PDF]

Microorganisms, 2023
Zauli RC, de Souza Perez IC, de Morais ACC, Ciaccio AC, Vidal AS, Soares RP, Torrecilhas AC, Batista WL, Xander P.   +8 more
europepmc   +1 more source

Assessment of PCR in the detection of Leishmania spp in experimentally infected individual phlebotomine sandflies (Diptera: Psychodidae: Phlebotominae)

Revista do Instituto de Medicina Tropical de São Paulo, 2002
DNA amplification by the polymerase chain reaction (PCR) was applied in the investigation of the presence of Leishmania (Kinetoplastida: Trypanosomatidae) parasites in single phlebotomine sandflies.
MICHALSKY Érika M., FORTES-DIAS Consuelo L., PIMENTA Paulo F.P., SECUNDINO Nágila F.C., DIAS Edelberto S.   +4 more
doaj  

Characterization of Sv129 Mice as a Susceptible Model to Leishmania amazonensis

Frontiers in Medicine, 2019
Leishmaniasis is a complex of neglected diseases caused by parasites of the genus Leishmania, such as Leishmania (Leishmania) amazonensis, the ethiologic agent of diffuse cutaneous leishmaniasis in Brazil. In this work, we investigated a new experimental
Júlio Souza dos-Santos, Luan Firmino-Cruz, Tadeu Diniz Ramos, Alessandra Marcia da Fonseca-Martins, Diogo Oliveira-Maciel, Juliana Valente Rodrigues De-Medeiros, Suzana Passos Chaves, Daniel Claudio Oliveira Gomes, Herbert Leonel de Matos Guedes, Herbert Leonel de Matos Guedes   +9 more
doaj   +1 more source

In Vitro Leishmanicidal Activity of Copaiba Oil and Kojic Acid Combination on the Protozoan Leishmania (Leishmania) amazonensis and Host Cell. [PDF]

Microorganisms, 2023
Moraes LS, Galué-Parra AJ, Hage AAP, Moura HA, Garcia MSA, Macêdo CG, Rodrigues APD, Guilhon GMSP, Silva EOD.   +8 more
europepmc   +1 more source

A Serine Protease from a Detergent-soluble Extract of Leishmania (Leishmania) amazonensis

Zeitschrift für Naturforschung C, 2004
Abstract Proteases mediate important crucial functions in parasitic diseases, and their characterization contributes to the understanding of host-parasite interaction. A serine protease was purified about 43-fold with a total recovery of 60% from a detergent-soluble extract of promastigotes of Leishmania amazonensis.
Raquel Elisa, da Silva Lopez, Salvatore Giovanni, De Simone   +1 more
openaire   +2 more sources

The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase

Experimental Parasitology, 2012
Polyamine biosynthesis enzymes are promising drug targets for the treatment of leishmaniasis, Chagas' disease and African sleeping sickness. Arginase, which is a metallohydrolase, is the first enzyme involved in polyamine biosynthesis and converts arginine into ornithine and urea.
da Silva, Edson Roberto, Maquiaveli, Claudia do Carmo, Magalhães, Prislaine Pupolin   +2 more
openaire   +2 more sources