Results 131 to 140 of about 6,626 (173)

Antibody response induced by structural proteins from <i>Triatoma virus</i> as potential adjuvants in experimental immunisation models. [PDF]

Front Microbiol
Queiroz AMV, do Nascimento Oliveira A, de Deus ARS, de Oliveira IEF, Dos Santos IA, Santos FLN, Celedon PAF, Guérin DMA, Viguera AR, Sousa-Silva M.   +9 more
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In vitro activity of cinnamaldehyde on Leishmania (Leishmania) amazonensis

Experimental Parasitology, 2022
Tegumentary leishmaniasis is an endemic disease that urgently needs new and effective treatments. L. amazonensis is one of the main species involved in the transmission of this infectious and non-contagious disease. The currently available treatments for leishmaniasis have high toxicity and vary in efficacy.
Aline Ávila Brustolin, Áquila Carolina Fernandes Herculano Ramos-Milaré, Tatiane França Perles de Mello, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Thaís Gomes Verzignassi Silveira   +5 more
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Antileishmanial activity of cordiaquinone E towards Leishmania (Leishmania) amazonensis

International Immunopharmacology, 2021
Leishmaniasis is caused by several protozoan species of Leishmania, and being endemically present in 98 countries around the world, it is also a severe public-health problem. The available antileishmanial drugs are toxic and yet present risks of recurrent infection. Efforts to find new, effective, and safe oral agents for the treatment of leishmaniasis
Raiza Raianne Luz, Rodrigues, Thaís Amanda Lima, Nunes, Alyne Rodrigues, de Araújo, José Delano Barreto, Marinho Filho, Marcos Vinícius, da Silva, Fernando Aécio de Amorim, Carvalho, Otília Deusdenia Loiola, Pessoa, Hozana Patrícia Silva, Freitas, Klinger Antonio da Franca, Rodrigues, Ana Jérsia, Araújo   +9 more
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Detection of Leishmania (Leishmania) amazonensis and Leishmania (Leishmania) infantum chagasi in Brazilian bats

Veterinary Parasitology, 2010
Although bats are one of the most abundant mammals in the new world and are present in virtually all ecosystems, including urban and peri-urban environments, few studies have investigated the role of these animals in the epidemiological chain of leishmaniosis.
Elisa San Martin Mouriz, Savani, Marilene Fernandes, de Almeida, Maria Cecília Gibrail, de Oliveira Camargo, Sandra Regina Nicoletti, D'Auria, Miriam Martos Sodré, Silva, Maria Lúcia, de Oliveira, Débora, Sacramento   +6 more
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Characterization of Leishmania (Leishmania) amazonensis promastigotes resistant to pentamidine

Experimental Parasitology, 2008
Pentamidine is a second-line agent used in the treatment of leishmaniasis and its mode of action and mechanism of resistance is not well understood. It was previously demonstrated that transfection of promastigotes and amastigotes with the ABC transporter PRP1 gene confers resistance to pentamidine.
Adriano C, Coelho, Luciana G, Gentil, José Franco, da Silveira, Paulo C, Cotrim   +3 more
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Biochemical characterization of serine transport in Leishmania (Leishmania) amazonensis

Molecular and Biochemical Parasitology, 2009
In addition to its role as a protein component in Leishmania, serine is also a precursor for the synthesis of both phosphatidylserine, which is a membrane molecule involved in parasite invasion and inactivation of macrophages, and sphingolipids, which are necessary for Leishmania to differentiate into its infective forms.
Marcos Gonzaga, dos Santos, Lisvane Silva, Paes, Ricardo Andrade, Zampieri, Maria Fernanda Laranjeira, da Silva, Ariel Mariano, Silber, Lucile Maria, Floeter-Winter   +5 more
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Antileishmanial Activity of Azitahromycin Against Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) chagasi

The American Journal of Tropical Medicine and Hygiene, 2008
Azithromycin, an azalide antibiotic, is highly concentrated within different phagocytic cells, especially macrophages. The potential antileishmanial activity of azithromycin against three species of Leishmania from the New World was assessed using in vitro models.
Fernanda, de Oliveira-Silva, Eliane, de Morais-Teixeira, Ana, Rabello   +2 more
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Leishmania amazonensis response to artemisinin and derivatives

Parasitology International, 2021
The worldwide presence of Leishmania parasites increases in the poorest regions. Current leishmaniasis treatments are unsatisfactory due to resistance development, side effects and cost. Herein, we describe the in vitro activity of artemisinin (ART), artemether (ATM), artesunate (ATS) and dihydroartemisinin (DHA) against Leishmania amazonensis ...
Laura, Machín, Rachel, Nápoles, Lars, Gille, Lianet, Monzote   +3 more
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A Serine Protease from a Detergent-soluble Extract of Leishmania (Leishmania) amazonensis

Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 2004
Abstract Proteases mediate important crucial functions in parasitic diseases, and their characterization contributes to the understanding of host-parasite interaction. A serine protease was purified about 43-fold with a total recovery of 60% from a detergent-soluble extract of promastigotes of Leishmania amazonensis.
Salvatore Giovanni De-Simone
exaly   +3 more sources

Genomic organization of telomeric and subtelomeric sequences of Leishmania (Leishmania) amazonensis

International Journal for Parasitology, 2005
Telomeres are DNA-protein complexes that protect linear chromosomes from degradation and fusions. Telomeric DNA is repetitive and G-rich, and protrudes towards the end of the chromosomes as 3'G-overhangs. In Leishmania spp., sequences adjacent to telomeres comprise the Leishmania conserved telomere associated sequences (LCTAS) that are around 100 bp ...
F F, Conte, M I N, Cano
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