Results 141 to 150 of about 6,626 (173)
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Veterinary Parasitology, 2008
The murine models of Leishmania infection are well-studied and suitable models for studying this disease, which, despite its incidence of nearly 2 million new cases worldwide per year and its prevalence of 12 million cases, has been a somewhat neglected disease.
Bernardo Acácio Santini, Pereira +1 more
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The murine models of Leishmania infection are well-studied and suitable models for studying this disease, which, despite its incidence of nearly 2 million new cases worldwide per year and its prevalence of 12 million cases, has been a somewhat neglected disease.
Bernardo Acácio Santini, Pereira +1 more
openaire +2 more sources
Experimental Parasitology, 2004
Pathogenic protozoan proteases play crucial roles in the host-parasite interaction, and its characterization contributes to the understanding of protozoan disease mechanisms. A Leishmania amazonensis promastigote protease was purified 36-fold, using aprotinin-agarose affinity chromatography and gel filtration high performance liquid chromatography ...
Raquel Elisa, da Silva-Lopez +1 more
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Pathogenic protozoan proteases play crucial roles in the host-parasite interaction, and its characterization contributes to the understanding of protozoan disease mechanisms. A Leishmania amazonensis promastigote protease was purified 36-fold, using aprotinin-agarose affinity chromatography and gel filtration high performance liquid chromatography ...
Raquel Elisa, da Silva-Lopez +1 more
openaire +2 more sources
Leishmania (Viannia) panamensis/Leishmania (Leishmania) amazonensis—A Warning
Parasitology Today, 1999The parasite Leishmania (Viannia) panamensis causes local cutaneous lesions. The Laboratory of Infectious Disease Pathology of the University of Sao Paulo Medical School has been working with a strain of Leishmania (Viannia) panamensis, HSJD-1, characterized by isoenzyme at the Liverpool School of Tropical Medicine, by W.
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Novel Selective Inhibitor of Leishmania (Leishmania) amazonensis Arginase
Chemical Biology & Drug Design, 2015Arginase is a glycosomal enzyme in Leishmania that is involved in polyamine and trypanothione biosynthesis. The central role of arginase in Leishmania (Leishmania) amazonensis was demonstrated by the generation of two mutants: one with an arginase lacking the glycosomal addressing signal and one in which the arginase‐coding gene was knocked out.
Edson R, da Silva +6 more
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Subcellular localization of an extracellular serine protease in Leishmania (Leishmania) amazonensis
Parasitology Research, 2004Extracellular proteolytic activity was detected in a Leishmania ( L.) amazonensis culture supernatant and a 56-kDa protein was purified using (NH4)2SO4 precipitation followed by affinity chromatography on aprotinin-agarose. A rabbit serum obtained against the 56-kDa extracellular serine protease was used in order to analyze its location in L.
R E, Silva-Lopez +4 more
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Polyamine N-acetyltransferase in Leishmania amazonensis
Parasitology Research, 1996N-Acetyltransferase, which is suggested to be responsible for the production of N1-acetylspermidine in Leishmania amazonensis and to be involved in the process of inactivation and degradation of excessive polyamines, was partially purified and characterized. Among the substrates tested, sym-norspermidine, sym-norspermine, and 1,3-diaminopropane had the
M, Rojas-Chaves +2 more
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Heme binding to Leishmania mexicana amazonensis
Molecular and Biochemical Parasitology, 1988Leishmania mexicana amazonensis is a pathogenic parasite whose growth, due to a biosynthetic deficiency, is dependent on a supply of exogenous heme. Utilizing [55Fe]hemin, we have demonstrated that heme binding to non-dividing cultured promastigotes of L. m.
R A, Galbraith, M J, McElrath
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Leishmania amazonensis: Acidic organelles in amastigotes
Experimental Parasitology, 1988Leishmania amastigotes are intracellular protozoan parasites which exclusively invade cells of the macrophage series and multiply within phagolysosomes. Recent studies showed that intracellular and isolated amastigotes of L. amazonesis are killed by amino acid esters which appear to be trapped within as yet unidentified, possibly acidified, "lysosome ...
J C, Antoine +3 more
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Active Transport of Glutamate in Leishmania (Leishmania) amazonensis
Journal of Eukaryotic Microbiology, 2008ABSTRACT. Leishmania spp. are the causative agents of leishmaniasis, a complex of diseases with a broad spectrum of clinical manifestations. Leishmania (Leishmania) amazonensis is a main etiological agent of diffuse cutaneous leishmaniasis. Leishmania spp., as other trypanosomatids, possess a metabolism based significantly on the consumption of amino
Lisvane S, Paes +5 more
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Veterinary Parasitology, 2004
BALB/c, C57BL/6, and DBA/2 mice were subcutaneously infected in the left footpad by injecting 10(4) Leishmania (Leishmania) amazonensis amastigotes. Mice were sacrificed 20, 30, 40, 60 and 90 days post-infection. Fragments of liver, kidney, spleen, skin, and draining lymph node were collected for histological examination.
A L, Abreu-Silva +5 more
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BALB/c, C57BL/6, and DBA/2 mice were subcutaneously infected in the left footpad by injecting 10(4) Leishmania (Leishmania) amazonensis amastigotes. Mice were sacrificed 20, 30, 40, 60 and 90 days post-infection. Fragments of liver, kidney, spleen, skin, and draining lymph node were collected for histological examination.
A L, Abreu-Silva +5 more
openaire +2 more sources