Results 181 to 190 of about 10,324 (216)
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The American Journal of Tropical Medicine and Hygiene, 2008
Azithromycin, an azalide antibiotic, is highly concentrated within different phagocytic cells, especially macrophages. The potential antileishmanial activity of azithromycin against three species of Leishmania from the New World was assessed using in vitro models.
Fernanda, de Oliveira-Silva +2 more
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Azithromycin, an azalide antibiotic, is highly concentrated within different phagocytic cells, especially macrophages. The potential antileishmanial activity of azithromycin against three species of Leishmania from the New World was assessed using in vitro models.
Fernanda, de Oliveira-Silva +2 more
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Leishmania amazonensis response to artemisinin and derivatives
Parasitology International, 2021The worldwide presence of Leishmania parasites increases in the poorest regions. Current leishmaniasis treatments are unsatisfactory due to resistance development, side effects and cost. Herein, we describe the in vitro activity of artemisinin (ART), artemether (ATM), artesunate (ATS) and dihydroartemisinin (DHA) against Leishmania amazonensis ...
Laura, Machín +3 more
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Genomic organization of telomeric and subtelomeric sequences of Leishmania (Leishmania) amazonensis
International Journal for Parasitology, 2005Telomeres are DNA-protein complexes that protect linear chromosomes from degradation and fusions. Telomeric DNA is repetitive and G-rich, and protrudes towards the end of the chromosomes as 3'G-overhangs. In Leishmania spp., sequences adjacent to telomeres comprise the Leishmania conserved telomere associated sequences (LCTAS) that are around 100 bp ...
F F, Conte, M I N, Cano
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Veterinary Parasitology, 2008
The murine models of Leishmania infection are well-studied and suitable models for studying this disease, which, despite its incidence of nearly 2 million new cases worldwide per year and its prevalence of 12 million cases, has been a somewhat neglected disease.
Bernardo Acácio Santini, Pereira +1 more
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The murine models of Leishmania infection are well-studied and suitable models for studying this disease, which, despite its incidence of nearly 2 million new cases worldwide per year and its prevalence of 12 million cases, has been a somewhat neglected disease.
Bernardo Acácio Santini, Pereira +1 more
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Experimental Parasitology, 2004
Pathogenic protozoan proteases play crucial roles in the host-parasite interaction, and its characterization contributes to the understanding of protozoan disease mechanisms. A Leishmania amazonensis promastigote protease was purified 36-fold, using aprotinin-agarose affinity chromatography and gel filtration high performance liquid chromatography ...
Raquel Elisa, da Silva-Lopez +1 more
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Pathogenic protozoan proteases play crucial roles in the host-parasite interaction, and its characterization contributes to the understanding of protozoan disease mechanisms. A Leishmania amazonensis promastigote protease was purified 36-fold, using aprotinin-agarose affinity chromatography and gel filtration high performance liquid chromatography ...
Raquel Elisa, da Silva-Lopez +1 more
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Leishmania (Viannia) panamensis/Leishmania (Leishmania) amazonensis—A Warning
Parasitology Today, 1999The parasite Leishmania (Viannia) panamensis causes local cutaneous lesions. The Laboratory of Infectious Disease Pathology of the University of Sao Paulo Medical School has been working with a strain of Leishmania (Viannia) panamensis, HSJD-1, characterized by isoenzyme at the Liverpool School of Tropical Medicine, by W.
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Novel Selective Inhibitor of Leishmania (Leishmania) amazonensis Arginase
Chemical Biology & Drug Design, 2015Arginase is a glycosomal enzyme in Leishmania that is involved in polyamine and trypanothione biosynthesis. The central role of arginase in Leishmania (Leishmania) amazonensis was demonstrated by the generation of two mutants: one with an arginase lacking the glycosomal addressing signal and one in which the arginase‐coding gene was knocked out.
Edson R, da Silva +6 more
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Subcellular localization of an extracellular serine protease in Leishmania (Leishmania) amazonensis
Parasitology Research, 2004Extracellular proteolytic activity was detected in a Leishmania ( L.) amazonensis culture supernatant and a 56-kDa protein was purified using (NH4)2SO4 precipitation followed by affinity chromatography on aprotinin-agarose. A rabbit serum obtained against the 56-kDa extracellular serine protease was used in order to analyze its location in L.
R E, Silva-Lopez +4 more
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Polyamine N-acetyltransferase in Leishmania amazonensis
Parasitology Research, 1996N-Acetyltransferase, which is suggested to be responsible for the production of N1-acetylspermidine in Leishmania amazonensis and to be involved in the process of inactivation and degradation of excessive polyamines, was partially purified and characterized. Among the substrates tested, sym-norspermidine, sym-norspermine, and 1,3-diaminopropane had the
M, Rojas-Chaves +2 more
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Heme binding to Leishmania mexicana amazonensis
Molecular and Biochemical Parasitology, 1988Leishmania mexicana amazonensis is a pathogenic parasite whose growth, due to a biosynthetic deficiency, is dependent on a supply of exogenous heme. Utilizing [55Fe]hemin, we have demonstrated that heme binding to non-dividing cultured promastigotes of L. m.
R A, Galbraith, M J, McElrath
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