Results 201 to 210 of about 66,437 (256)
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In vitro activity of cinnamaldehyde on Leishmania (Leishmania) amazonensis.
Experimental Parasitology, 2022Tegumentary leishmaniasis is an endemic disease that urgently needs new and effective treatments. L. amazonensis is one of the main species involved in the transmission of this infectious and non-contagious disease. The currently available treatments for
Aline Ávila Brustolin +5 more
semanticscholar +3 more sources
Novel Selective Inhibitor of Leishmania (Leishmania) amazonensis Arginase
Chemical Biology & Drug Design, 2015Arginase is a glycosomal enzyme in Leishmania that is involved in polyamine and trypanothione biosynthesis. The central role of arginase in Leishmania (Leishmania) amazonensis was demonstrated by the generation of two mutants: one with an arginase lacking the glycosomal addressing signal and one in which the arginase‐coding gene was knocked out.
Edson R. Silva +6 more
semanticscholar +3 more sources
Veterinary Parasitology, 2010
Although bats are one of the most abundant mammals in the new world and are present in virtually all ecosystems, including urban and peri-urban environments, few studies have investigated the role of these animals in the epidemiological chain of leishmaniosis.
E. Savani +6 more
semanticscholar +3 more sources
Although bats are one of the most abundant mammals in the new world and are present in virtually all ecosystems, including urban and peri-urban environments, few studies have investigated the role of these animals in the epidemiological chain of leishmaniosis.
E. Savani +6 more
semanticscholar +3 more sources
Veterinary Parasitology, 2008
The murine models of Leishmania infection are well-studied and suitable models for studying this disease, which, despite its incidence of nearly 2 million new cases worldwide per year and its prevalence of 12 million cases, has been a somewhat neglected disease.
B. A. S. Pereira, C. R. Alves
semanticscholar +3 more sources
The murine models of Leishmania infection are well-studied and suitable models for studying this disease, which, despite its incidence of nearly 2 million new cases worldwide per year and its prevalence of 12 million cases, has been a somewhat neglected disease.
B. A. S. Pereira, C. R. Alves
semanticscholar +3 more sources
Leishmania (Leishmania) amazonensis.
Trends in ParasitologyM. A. Garcia +4 more
semanticscholar +3 more sources
International journal of pharmaceutics, 2023
Epoxy-α-lapachone (ELAP), an oxirane-functionalized molecule synthesized from naturally occurring lapachol, has shown promising activity against murine infection with Leishmania (Leishmania) amazonensis.
Juliana Figueiredo Peixoto +15 more
semanticscholar +1 more source
Epoxy-α-lapachone (ELAP), an oxirane-functionalized molecule synthesized from naturally occurring lapachol, has shown promising activity against murine infection with Leishmania (Leishmania) amazonensis.
Juliana Figueiredo Peixoto +15 more
semanticscholar +1 more source
Antileishmanial activity of cordiaquinone E towards Leishmania (Leishmania) amazonensis
International Immunopharmacology, 2021Leishmaniasis is caused by several protozoan species of Leishmania, and being endemically present in 98 countries around the world, it is also a severe public-health problem. The available antileishmanial drugs are toxic and yet present risks of recurrent infection. Efforts to find new, effective, and safe oral agents for the treatment of leishmaniasis
Raiza Raianne Luz, Rodrigues +9 more
openaire +2 more sources
Journal of Leukocyte Biology, 2020
B‐1 cells are a B‐lymphocyte subtype whose roles in immunity are not completely defined. These cells can produce cytokines (mainly IL‐10) and natural and specific antibodies.
M. Toledo +7 more
semanticscholar +1 more source
B‐1 cells are a B‐lymphocyte subtype whose roles in immunity are not completely defined. These cells can produce cytokines (mainly IL‐10) and natural and specific antibodies.
M. Toledo +7 more
semanticscholar +1 more source
The American Journal of Tropical Medicine and Hygiene, 2008
Azithromycin, an azalide antibiotic, is highly concentrated within different phagocytic cells, especially macrophages. The potential antileishmanial activity of azithromycin against three species of Leishmania from the New World was assessed using in vitro models.
Fernanda, de Oliveira-Silva +2 more
openaire +2 more sources
Azithromycin, an azalide antibiotic, is highly concentrated within different phagocytic cells, especially macrophages. The potential antileishmanial activity of azithromycin against three species of Leishmania from the New World was assessed using in vitro models.
Fernanda, de Oliveira-Silva +2 more
openaire +2 more sources