Results 111 to 120 of about 4,849,377 (223)

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, Volume 40, Issue 10, Page 5951-5972, October 2026.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

The activity of azithromycin against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis in the golden hamster model A atividade da azitromicina contra a Leishmania (Viannia) braziliensis e a Leishmania (Leishmania) amazonensis no modelo golden hamster

Revista da Sociedade Brasileira de Medicina Tropical, 2007
New therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania (Leishmania) major has been previously demonstrated.
Ángel Sinagra, Concepción Luna, David Abraham, Maria del Carmen Iannella, Adelina Riarte, Alejandro J. Krolewiecki   +5 more
doaj   +1 more source

Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá, Damião Sampaio de Sousa, Caio Henrique Alexandre Roberto, Márcia Machado Marinho, Emmanuel Silva Marinho   +4 more
wiley   +1 more source

Phlebotomine Sand Flies (Diptera: Psychodidae) in Iran and their Role on Leishmania Transmission

Journal of Arthropod-Borne Diseases, 2012
Sand fly research has a long history in Iran beginning with the work of Adler, Theodor and Lourie in 1930 and followed by Mesghali’s foundational taxonomic work on sand flies in 1943. Since then, research has continued unabated throughout the country and
MR Yaghoobi-Ershadi
doaj  

Geographical Distribution of Leishmania Species of Human Cutaneous Leishmaniasis in Fars Province, Southern Iran

Iranian Journal of Parasitology, 2013
Background: The goal of this study was to know the identity of Leishmania species responsible of cutaneous leishmaniasis (CL) in Fars Province, southern Iran.Methods: Five counties of Shiraz, Firouz Abad, Ghir-Karzin, Farashband and Larestan were pros ...
M Akhoundi, H Hajjaran, A Baghaei, M Mohebali   +3 more
doaj   +2 more sources

Synthesis, Anti‐Leishmania amazonensis Activity, Cytotoxicity, and Molecular Docking of Anthranilate–Naphthoquinone Hybrids

ChemistrySelect, Volume 11, Issue 40, 27 October 2026.
New anthranilate–naphthoquinone hybrids display potent inhibition of Leishmania (L.) amazonensis with low host cell toxicity. Molecular docking reveals key interactions with TR, GP63, and PTR1, suggesting a multitarget mechanism that contributes to parasite death.
Eduardo Miranda da Silva Magesfeste, Lidilhone Hamerski, Diego Mendes Nunes, Ana Paula Sotero da Silva Ribeiro, Elvira Maria Saraiva, Magaly Girão Albuquerque, Camilo Henrique da Silva Lima, Bárbara Vasconcellos da Silva   +7 more
wiley   +1 more source

Developmentally Regulated Sphingolipid Degradation in Leishmania major

PLoS ONE, 2012
Leishmania parasites alternate between extracellular promastigotes in sandflies and intracellular amastigotes in mammals. These protozoans acquire sphingolipids (SLs) through de novo synthesis (to produce inositol phosphorylceramide) and salvage (to obtain sphingomyelin from the host).
Ou Zhang, Wei Xu, Agiesh Balakrishna Pillai, Kai Zhang   +3 more
openaire   +4 more sources

Molecular Characterization of Non‐Specific Esophagitis Reveals a Distinct Non‐Eosinophilic Phenotype With Fibrotic Traits

Allergy, Volume 81, Issue 10, Page 3620-3630, October 2026.
This study comprehensively characterizes non‐specific esophagitis and elucidates eosinophil‐independent fibrosis mechanisms. NSE appears to be a distinct fibrotic phenotype of the esophagus, without any considerable overlap with GERD and other chronic inflammatory disorders such as EoE or lymphocytic esophagitis.
Marc Pfefferle, Darko Stojkov, Dagmar Simon, Emilie Gueguen, Marcin Wawrzyniak, Margaret H. Collins, Mirna Chehade, Evan S. Dellon, Glenn T. Furuta, Ikuo Hirano, Nirmala Gonsalves, Fouad J. Moawad, Luc Biedermann, Alain M. Schoepfer, Alex Straumann, Hans‐Uwe Simon, Thomas Greuter   +16 more
wiley   +1 more source

Comparison of Intralesional Sodium Stibogluconate versus Intralesional Meglumine Antimoniate for the Treatment of Leishmania major Cutaneous Leishmaniasis

Acta Dermato-Venereologica
Israel is endemic for Old-World cutaneous leishmaniasis. The most common species is Leishmania major. However, the available treatment options are limited.
Michal Solomon, Ayelet Ollech , Felix Pavlotsky , Aviv Barzilai , Eli Schwartz, Sharon Baum , Nadav Astman   +6 more
doaj   +1 more source

Leishmaniasis in central and southern Tunisia: current geographical distribution of zymodemes

Parasite, 2007
The authors report the identification of Leishmania strains isolated from the Centre and the South of Tunisia. 266 strains were isolated between 1998 and 2006 from human (n = 221 strains) and dogs (n = 45 strains) hosts.
Haouas N., Gorcii M., Chargui N., Aoun K., Bouratbine A., Messaadi Akrout F., Masmoudi A., Zili J., Ben Said M., Pratlong F., Dedet J.P., Mezhoud H., Azaiez R., Babba H.   +13 more
doaj   +1 more source