Results 121 to 130 of about 9,977 (186)

Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8

, 2013
Cysteine protease B is considered crucial for the survival and infectivity of the Leishmania in its human host. Several microorganism pathogens bind to the heparin-like glycosaminoglycans chains of proteoglycans at host-cell surface to promote their ...
Gesteira, Tarsis F., Tarsis F Gesteira, Gesteira Tarsis F., Sanya J Sanderson, Tersariol, Ivarne L.S., Westrop, Gareth, Sansevero, Thiago M., Shida, Claudio S. [UNIFESP], Manfredi, Marcella A, Tersariol, Ivarne Luis dos Santos [UNIFESP], Gerson P Souza, Ivarne L S Tersariol, Luiz Juliano, Manfredi Marcella A., Gareth D Westrop, Sansevero Thiago M., Almeida Paulo C., Tersariol Ivarne L. S., Souza, Gerson A., Manfredi, Marcella A., Sanderson Sanya J., Thiago M Sansevero, Souza, Gerson P., Juliano, Luiz, Westrop, Gareth D., Almeida, Paulo C. [UNIFESP], Judice, W.A.S., Paulo C Almeida, Judice Wagner A. S., Coombs Graham H., Coombs, Graham H., Shida, Claudio S., Shida Cláudio S., Cláudio S Shida, Souza Gerson P., Almeida, Paulo C, Judice, Wagner A. S., Marcella A Manfredi, Sanderson, Sanya J, Coombs, Graham, Juliano, Luiz [UNIFESP], Wagner A S Judice, Juliano Luiz, Sanderson, Sanya J., Graham H Coombs, Westrop Gareth D.   +45 more
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Geographical Distribution of Leishmania Species of Human Cutaneous Leishmaniasis in Fars Province, Southern Iran

Iranian Journal of Parasitology, 2013
Background: The goal of this study was to know the identity of Leishmania species responsible of cutaneous leishmaniasis (CL) in Fars Province, southern Iran.Methods: Five counties of Shiraz, Firouz Abad, Ghir-Karzin, Farashband and Larestan were pros ...
M Akhoundi, H Hajjaran, A Baghaei, M Mohebali   +3 more
doaj   +2 more sources

BALB/c mice deficient in CD4(+) T cell IL-4R alpha expression control Leishmania mexicana load although female but not male mice develop a healer phenotype [PDF]

, 2011
Immunologically intact BALB/c mice infected with Leishmania mexicana develop non-healing progressively growing lesions associated with a biased Th2 response while similarly infected IL-4R alpha-deficient mice fail to develop lesions and develop a robust ...
Owain R Millington, Bryson Karen J., Millington Owain R., McGachy, Adrienneh H., Brombacher, F, Mokgethi Thabang, Bryson, Karen, H. Adrienne McGachy, Owain R. Millington, McGachy, Adrienne, H Adrienne McGachy, James Alexander, Mokgethi, T, Karen J Bryson, Alexander, James, Brombacher Frank, Frank Brombacher, Alexander James, McGachy, Helen, Bryson, Karen J., Thabang Mokgethi, Millington, Owain R., Millington, Owain, Brombacher, Frank, Mokgethi, Thabang, Bryson, Karen J, Karen J. Bryson, McGachy, H Adrienne, McGachy H. Adrienne, Millington, Owain R   +29 more
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Leishmaniasis in central and southern Tunisia: current geographical distribution of zymodemes

Parasite, 2007
The authors report the identification of Leishmania strains isolated from the Centre and the South of Tunisia. 266 strains were isolated between 1998 and 2006 from human (n = 221 strains) and dogs (n = 45 strains) hosts.
Haouas N., Gorcii M., Chargui N., Aoun K., Bouratbine A., Messaadi Akrout F., Masmoudi A., Zili J., Ben Said M., Pratlong F., Dedet J.P., Mezhoud H., Azaiez R., Babba H.   +13 more
doaj   +1 more source

Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms [PDF]

, 1992
A new method is described which has made possible the long-term axenic cultivation of Leishmania mexicana amastigote-like forms in Schneider's Drosophila medium supplemented with 20% (v/v) foetal calf serum.
Coombs, G H, Robertson, C D, Tetley, L, Bates, P A   +3 more
core  

Comparison of Intralesional Sodium Stibogluconate versus Intralesional Meglumine Antimoniate for the Treatment of Leishmania major Cutaneous Leishmaniasis

Acta Dermato-Venereologica
Israel is endemic for Old-World cutaneous leishmaniasis. The most common species is Leishmania major. However, the available treatment options are limited.
Michal Solomon, Ayelet Ollech , Felix Pavlotsky , Aviv Barzilai , Eli Schwartz, Sharon Baum , Nadav Astman   +6 more
doaj   +1 more source

Detection of Leishmania major using PCR-ELISA

Medical Laboratory Journal, 2022
Background and objectives: Cutaneous leishmaniasis is endemic in most areas of Iran, and the diagnosis of its species is essential for controlling the disease. Leishmania major is the causative agent for cutaneous leishmaniasis in humans.
Afieh Samimi, Oghol Niaz Jorjani, Zohreh Sharifi, Faramarz Koohsar, khodaberdi kalavi, Fatemeh Mesgarian, Beniamin Talebi   +6 more
doaj  

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice

, 2009
The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infections marks a phagosome stage at which decisions over pathogen replication or destruction are integrated.
Paape, Daniel, Blackburn, Clare, Lippuner, C., Smith, Andrew, Smith, A. J., Paterou, A., Brand, J., Richardson, Melville, Richardson, M., Blackburn, C., Andrew J. Smith, Volker Brinkmann, Brinkmann, Volker, Janko Brand, Smith, A., Brinkmann, V., Daniel Paape, Toni Aebischer, Brand, Janko, Hoffmann, Kirstin, Hoffmann, K., Athina Paterou, Kirstin Hoffmann, Aebischer, Toni, Paterou, Athina, Paape, D., Clare Blackburn, Smith, Andrew J., Melville Richardson, Aebischer, T., Christoph Lippuner, Lippuner, Christoph   +31 more
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Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa.

, 2005
In this paper we describe the preparation of some biphenylquinuclidine derivatives and their evaluation as inhibitors of squalene synthase in order to explore their potential in the treatment of the parasitic diseases leishmaniasis and Chagas disease ...
Croft, Simon L, Cammerer, Simon, Gilbert, Ian H, Orenes Lorente, Silvia, Ruiz Perez, Luis M, Urbina, Julio, Gonzalez Pacanowska, Dolores, Jiménez, Carmen, Pacanowska, Dolores Gonzalez, de Luca-Fradley, Kate, Gómez, Rosario, Perez, Luis M. Ruiz, Gilbert, Ian H., Lorente, Silvia Orenes, Yardley, Vanessa, Croft, Simon L.   +15 more
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The Leishmania donovani complex: genotypes of five metabolic enzymes (ICD, ME, MPI, G6PDH, and FH), new targets for multilocus sequence typing.

, 2007
Flagellates of the Leishmania donovani complex are causative agents of human cutaneous and visceral leishmaniasis. The complex is comprised of L. donovani, Leishmania infantum and Leishmania archibaldi, although the latter is not now considered to be a ...
Jirků, Milan, Mauricio, Isabel L, Zemanová, Eva, Lukes, Julius, Miles, Michael A, Horák, Ales   +5 more
core   +1 more source