Results 121 to 130 of about 71,650 (224)

A prime/boost DNA/Modified vaccinia virus Ankara vaccine expressing recombinant Leishmania DNA encoding TRYP is safe and immunogenic in outbred dogs, the reservoir of zoonotic visceral leishmaniasis [PDF]

Previous studies demonstrated safety, immunogenicity and efficacy of DNA/modified vaccinia virus Ankara (MVA) prime/boost vaccines expressing tryparedoxin peroxidase (TRYP) and Leishmania homologue of the mammalian receptor for activated C kinase (LACK ...
Alcami, Antonio, Antoniou, Maria, Begoña Ruiz-Argüello, Maria, Blackwell, Jenefer M., Carson, Connor, Christodoulou, Vasiliki, Courtenay, Orin, Messaritakis, Ippokratis   +7 more
core   +1 more source

Nucleoside Hydrolase from Leishmania major [PDF]

Journal of Biological Chemistry, 1999
Wuxian Shi, Vern L. Schramm, Steven C. Almo   +2 more
openaire   +1 more source

Transcriptional signatures in human macrophage-like cells infected by Leishmania infantum, Leishmania major and Leishmania tropica

PLOS Neglected Tropical Diseases
Background In the Mediterranean basin, three Leishmania species have been identified: L. infantum, L. major and L. tropica, causing zoonotic visceral leishmaniasis (VL), zoonotic cutaneous leishmaniasis (CL) and anthroponotic CL, respectively. Despite animal models and genomic/transcriptomic studies provided important insights, the pathogenic ...
Diotallevi, Aurora, Bruno, Federica, Castelli, Germano, Persico, Giuseppe, Buffi, Gloria, Ceccarelli, Marcello, Ligi, Daniela, Mannello, Ferdinando, Vitale, Fabrizio, Magnani, Mauro, Galluzzi, Luca   +10 more
openaire   +3 more sources

Evaluation of the Paraquat Effect on Leishmania major Promastigotes and HUVECs Viability under in vitro Condition

Journal of Ardabil University of Medical Sciences, 2019
Background & objectives: Pentavalent antimonials are the first-line drugs for treatment of leishmaniasis, which have multiple side effects such as drug toxicity. Moreover, parasite resistance to these drugs is rising around the world.
Ali Niapour, Keyvan Amirshahrokhi, Mohammad Azari Rad, Behnam Mohammadi-ghalehbin B   +3 more
doaj  

Risk factors for visceral leishmaniasis in a new epidemic site in Amhara Region, Ethiopia [PDF]

, 2009
We conducted a case-control study to evaluate risk factors for visceral leishmaniasis during an epidemic in a previously unaffected district of Ethiopia. We also collected blood and bone marrow specimens from dogs in the outbreak villages.
Alvar, Jorge, Aparicio, Pilar, Argaw, Daniel, Bashaye, Seife, Bern, Caryn, Cañavate, Carmen, Chicharro, Carmen, Herrero, Merce, Mulugeta, Abate, Nieto, Javier, Nombela, Nohelly, Vélez, Iván Darío   +11 more
core   +1 more source

Sequence Analysis of HSP70 Gene of Leishmania major and Leishmania tropica in Chabahar and Mashhad

Medical Laboratory Journal, 2016
Background and Objective: Cutaneous leishmaniasis is a parasitic disease and a health problem in different parts of Iran, especially two cities of Mashhad and Chabahar.
Mansour Dabirzadeh, Abbas Pashaie Neghadeh, Tahere Davoodi, Mohammad Hashemi   +3 more
doaj  

The recombinant protein of scorpion venom phospholipase A2 exhibits potential anti-leishmanial activity

Scientific Reports
The venom of scorpions contains a diverse array of bioactive compounds, including mucoproteins, nucleotides, and enzymes. Among these, phospholipase A2 (PLA2) plays a critical role in hydrolyzing plasma membrane phospholipids, leading to the release of ...
Parisa Soltan-Alinejad, Amin Ramezani, Qasem Asgari, Hamzeh Alipour, Aboozar Soltani, Mohammad Saleh Bahreini, Mahmood Nikbakhtzadeh, Kourosh Azizi   +7 more
doaj   +1 more source

Effect of interleukin-22 on immunogenicity of DNA vaccine encoding TSA gene of leishmania major in BALB/c mice [PDF]

, 2014
Background and purpose: Previous Research shows the use of plasmids containing genes TSA to be useful as vaccines for Leishmania major. Recently, the role of interleukin-22 (IL-22) in tissue repair has been demonstrated.
Dalimi-Asl, A., Ghaffarifar, F., Niaz-Jorjani, O., Sharifi, Z., Ziaei-Hezarjaribi, H.   +4 more
core  

Resolution of an Infection with Leishmania braziliensis Confers Complete Protection to a Subsequent Challenge with Leishmania major in BALB/c Mice

Memorias do Instituto Oswaldo Cruz, 1999
Both Leishmania major and L. braziliensis induce cutaneous leishmaniasis in BALB/c mice. Whereas BALB/c mice die of infection with L. major, they cure an infection with L. braziliensis. We report here that after curing an infection with L.
Lima Hermenio C, DeKrey Gregory K, Titus Richard G   +2 more
doaj  

Synthesis and Biological Evaluation of Imidazopyridine-Isatin Hybrids as Inhibitors of <i>Leishmania major</i> Growth. [PDF]

Drug Des Devel Ther
El Hassab MA, Eldehna WM, Elsayed ZM, Elbadawi MM, Negmeldin AT, Balaha M, Nasralla SN, Monir R, Ibrahim TM, Abe M, Tawfik HO, Bekhit AA, Hemeda LR.   +12 more
europepmc   +1 more source