First detection of Leishmania major in dogs living in an endemic area of zoonotic cutaneous leishmaniasis in Tunisia [PDF]
Parasites & VectorsAbstract Background Dogs are considered the main domestic animals that may be a reservoir for Leishmania infantum, the agent of zoonotic visceral leishmaniasis (ZVL) in several countries of the world.
Maria Paola Maurelli +10 more
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Antigen recognition reinforces regulatory T cell mediated Leishmania major persistence [PDF]
Nature Communications, 2023 Cutaneous Leishmania major infection elicits a rapid T cell response that is insufficient to clear residually infected cells, possibly due to the accumulation of regulatory T cells in healed skin.
Romaniya Zayats +8 more
doaj +2 more sources
Comparison of Intralesional Sodium Stibogluconate versus Intralesional Meglumine Antimoniate for the Treatment of Leishmania major Cutaneous Leishmaniasis [PDF]
Acta Dermato-VenereologicaIsrael is endemic for Old-World cutaneous leishmaniasis. The most common species is Leishmania major. However, the available treatment options are limited.
Michal Solomon +6 more
doaj +2 more sources
The nanoemulsion-based nanogel of Artemisia dracunculus essential oil with proper activity against Leishmania tropica and Leishmania major [PDF]
Nanomedicine Research Journal, 2021 Cutaneous leishmaniasis is the most common form of leishmaniasis that is distributed in around 100 countries. Preparing essential oil-based nanoformulations with the leishmanicidal effect is a promising strategy for the development of new drugs.
Ali Ghanbariasad +3 more
doaj +1 more source
Overview of the organization of protease genes in the genome of Leishmania spp
Parasites & Vectors, 2014 Background The genus Leishmania includes protozoan parasites that are able to infect an array of phlebotomine and vertebrate species. Proteases are related to the capacity of these parasites to infect and survive in their hosts and are therefore ...
Mariana Silva-Almeida +4 more
doaj +1 more source
Leishmania vaccines entered in clinical trials: A review of literature
International Journal of Preventive Medicine, 2019 Leishmaniasis is considered as a zoonotic infection and neglected tropical disease. Leishmania treatment is not totally successful and imposes high expenditures, especially in developing countries. Since the natural infection leads to the robust immunity
Mohammad Moafi +3 more
doaj +1 more source
Vaccination with Leishmania mexicana LPG induces PD-1 in CD8+ and PD-L2 in macrophages thereby suppressing the immune response: A model to assess vaccine efficacy [PDF]
Vaccine Volume 32, Issue 11, 5 March 2014, Pages 1259-1265, 2019 Leishmania lipophosphoglycan is a molecule that has been used as a vaccine candidate, with contradictory results. Since unsuccessful protection could be related to suppressed T cell responses, we analyzed the expression of inhibitory receptor PD-1 in CD8+ and CD4+ lymphocytes and it is ligand PD-L2 in macrophages of BALB/c mice immunized with various ...
arxiv +1 more source
In vitro and in vivo antileishmanial efficacy of a combination therapy of diminazene and artesunate against Leishmania donovani in BALB /c mice [PDF]
Rev. Inst. Med. Trop. Sao Paulo. 2011, 53 (3): 129 - 132, 2011 The in vitro and in vivo activity of diminazene (Dim), artesunate (Art) and combination of Dim and Art (Dim-Art) against Leishmania donovani was compared to reference drug; amphotericin B. IC50 of Dim-Art was found to be $2.28 \pm 0.24 \mu$ g/mL while those of Dim and Art were $9.16 \pm 0.3 \mu$ g/mL and $4.64 \pm 0.48 \mu$ g/mL respectively.
arxiv +1 more source
Transient superdiffusion and long-range correlations in the motility patterns of trypanosomatid flagellate protozoa [PDF]
PLoS ONE 11(3): e0152092 (2016), 2016 We report on a diffusive analysis of the motion of flagellate protozoa species. These parasites are the etiological agents of neglected tropical diseases: leishmaniasis caused by Leishmania amazonensis and Leishmania braziliensis, African sleeping sickness caused by Trypanosoma brucei, and Chagas disease caused by Trypanosoma cruzi.
arxiv +1 more source
Estimating the concentration of gold nanoparticles incorporated on Natural Rubber membranes using Multi-Level Starlet Optimal Segmentation [PDF]
J Nanopart Res (2014) 16: 2809, 2016 This study consolidates Multi-Level Starlet Segmentation (MLSS) and Multi-Level Starlet Optimal Segmentation (MLSOS), techniques for photomicrograph segmentation that use starlet wavelet detail levels to separate areas of interest in an input image.
arxiv +1 more source