Results 21 to 30 of about 4,660,147 (222)

The Genome of the Kinetoplastid Parasite, Leishmania major [PDF]

Science, 2005
Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 ...
Ivens, A.C., Peacock, C.S., Worthey, E.A., Murphy, L., Aggarwal, G., Berriman, M., Sisk, E., Rajandream, M.A., Adlem, E., Aert, Rita, Anupama, A., Myler, P.J., Apostolou, Z., Attipoe, P., Bason, N., Bauser, C., Beck, A., Beverley, S.M., Bianchettin, G., Borzym, K., Bothe, G., Bruschi, C.V., Collins, M., Cadag, E., Ciarloni, L., Clayton, C., Coulson, R.MR., Cronin, A., Cruz, A.K., Davies, R.M., De Gaudenzi, J., Dobson, D.E., Duesterhoeft, A., Fazelina, G., Fosker, N., Frasch, A.C., Fraser, A., Fuchs, M., Gabel, C., Goble, A., Goffeau, A., Harris, D., Hertz-Fowler, C., Hilbert, H., Horn, D., Huang, Y.T., Klages, S., Knights, A., Kube, M., Larke, N., Litvin, L., Lord, A., Louie, T., Marra, M., Masuy, D., Matthews, K., Michaeli, S., Mottram, J.C., Muller-Auer, S., Munden, H., Nelson, S., Norbertczak, H., Oliver, K., O'Neil, S., Pentony, M., Pohl, T.M., Price, C., Purnelle, B., Quail, M.A., Rabbinowitsch, E., Reinhardt, R., Rieger, M., Rinta, J., Robben, Johan, Robertson, L., Ruiz, J.C., Rutter, S., Saunders, D., Schafer, M., Schein, J., Schwartz, D.C., Seeger, K., Seyler, A., Sharp, S., Shin, H., Sivam, D., Squares, R., Squares, S., Tosato, V., Vogt, C., Volckaert, Guido, Wambutt, R., Warren, T., Wedler, H., Woodward, J., Zhou, S.G., Zimmermann, W., Smith, D.F., Blackwell, J.M., Stuart, K.D., Barrell, B.   +100 more
openaire   +6 more sources

Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response [PDF]

, 2012
Background: Leishmania (L.) species are the causative agent of leishmaniasis. Due to the lack of efficient vaccine candidates, drug therapies are the only option to deal with cutaneous leishmaniasis.
Uwe Ritter (130470), Schmid, Maximilian, Hanses Frank, Ulrike Schleicher (104689), Frank Hanses, Maximilian Schmid, Florian, Christian, Frank Hanses (148604), Zimara Nicole, Wolfgang Ernst (13060), Wege, Anja Kathrin, Anja Kathrin Wege, Anja Kathrin Wege (148586), Christian Florian, Ernst, Wolfgang, Uwe Ritter, Hanses, Frank, Maximilian Schmid (148609), Florian Christian, Ritter Uwe, Nicole Zimara (148595), Zimara, Nicole, Christian Florian (148590), Schleicher, Ulrike, Ritter, Uwe, Nicole Zimara, Ernst Wolfgang, Schmid Maximilian, Schleicher Ulrike, Wege Anja Kathrin, Wolfgang Ernst, Ulrike Schleicher   +31 more
core   +2 more sources

Structure ofLeishmania majorcysteine synthase [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2012
Cysteine biosynthesis is a potential target for drug development against parasiticLeishmaniaspecies; these protozoa are responsible for a range of serious diseases. To improve understanding of this aspect ofLeishmaniabiology, a crystallographic and biochemical study ofL.
Fyfe, Paul K, Westrop, Gareth D, Ramos, Tania, Müller, Sylke, Coombs, Graham H, Hunter, William N   +5 more
openaire   +5 more sources

Updates on Geographical Dispersion of Leishmania Parasites Causing Cutaneous Affections in Algeria

Pathogens, 2021
Leishmaniases are neglected tropical diseases of public health concern in Algeria. To update the geographical distribution of Leishmania spp. causing cutaneous affection, we examined a set of Giemsa-stained smears prepared from skin lesions of the ...
Arezki Izri, Amina Bendjaballah-Laliam, Denis Sereno, Mohammad Akhoundi   +3 more
doaj   +1 more source

Cyclic nucleotide specific phosphodiesterases of Leishmania major [PDF]

BMC Microbiology, 2006
Abstract Background Leishmania represent a complex of important human pathogens that belong to the systematic order of the kinetoplastida. They are transmitted between their human and mammalian hosts by different bloodsucking sandfly vectors.
Johner A, Kunz S, Linder M, Shakur Y, Seebeck T   +4 more
openaire   +4 more sources

Leishmania vaccines entered in clinical trials: A review of literature

International Journal of Preventive Medicine, 2019
Leishmaniasis is considered as a zoonotic infection and neglected tropical disease. Leishmania treatment is not totally successful and imposes high expenditures, especially in developing countries. Since the natural infection leads to the robust immunity
Mohammad Moafi, Hossein Rezvan, Roya Sherkat, Roya Taleban   +3 more
doaj   +1 more source

Comorbidity of Leishmania major with cutaneous sarcoidosis

Indian Journal of Dermatology, 2014
leishmaniasis infection might manifest as sarcoidosis; on the other hand, some evidences propose an association between sarcoidosis and leishmaniasis. Most of the times, it is impossible to discriminate idiopathic sarcoidosis from leishmaniasis by conventional histopathologic exam.We performed a cross-sectional study to examine the association of ...
Hamideh Moravvej, Parvaneh Vesal, Ehsan Abolhasani, Shizar Nahidi, Fereidoun Mahboudi   +4 more
openaire   +3 more sources

Leishmania major, the Predominant Leishmania Species Responsible for Cutaneous Leishmaniasis in Mali [PDF]

The American Society of Tropical Medicine and Hygiene, 2013
Leishmania major is the only species of Leishmania known to cause cutaneous leishmanisis (CL) in Mali. We amplified Leishmania DNA stored on archived Giemsa-stained dermal scraping slides obtained from self-referral patients with clinically suspected CL seen in the Center National d'Appui A La Lutte Contre La Maladie (CNAM) in Bamako, Mali, to ...
Carlos, Paz, Sibiry, Samake, Jennifer M, Anderson, Ousmane, Faye, Pierre, Traore, Koureishi, Tall, Moumine, Cisse, Somita, Keita, Jesus G, Valenzuela, Seydou, Doumbia   +9 more
openaire   +2 more sources

Comparative Gene Expression Profiles of Leishmania major and Leishmania infantum Promastigotesa

Turkiye parazitolojii dergisi, 2021
This study aimed to determine the differences between the gene expression profiles of Leismania major and Leishmania infantum promastigotes through comparative analysis of gene expressions.Cell culture of L. major (MHOM/IL/80) and L. infantum (MHOM/MA/67/ITMAP/263) cell lines was performed.
Özlem Ulusan Bağcı, Aygül Sadıqova, Ayşe Caner   +2 more
openaire   +3 more sources

Metabolic variation during development in culture of Leishmania donovani promastigotes [PDF]

, 2011
The genome sequencing of several Leishmania species has provided immense amounts of data and allowed the prediction of the metabolic pathways potentially operating.
Cordeiro-da-Silva, Anabela, Coombs, Graham H, Silva, Ana Marta   +2 more
core   +5 more sources