The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host [PDF]
, 2013 Bardet–Biedl syndrome (BBS) is a human genetic disorder with a spectrum of symptoms caused by primary cilium dysfunction. The disease is caused by mutations in one of at least 17 identified genes, of which seven encode subunits of the BBSome, a protein ...
Doehl, Johannes +6 more
core +1 more source
LmaPA2G4, a Homolog of Human Ebp1, Is an Essential Gene and Inhibits Cell Proliferation in L. major [PDF]
, 2014 We have identified LmaPA2G4, a homolog of the human proliferation-associated 2G4 protein (also termed Ebp1), in aphosphoproteomic screening. Multiple sequence alignment and cluster analysis revealed that LmaPA2G4 is a non-peptidasemember of the M24 ...
Joyce, Michelle V. +4 more
core +12 more sources
Overview of the organization of protease genes in the genome of Leishmania spp
Parasites & Vectors, 2014 Background The genus Leishmania includes protozoan parasites that are able to infect an array of phlebotomine and vertebrate species. Proteases are related to the capacity of these parasites to infect and survive in their hosts and are therefore ...
Mariana Silva-Almeida +4 more
doaj +1 more source
Novel Compounds Active against Leishmania major [PDF]
Antimicrobial Agents and Chemotherapy, 2006 ABSTRACT Leishmania major is an important trypanosomatid pathogen that causes leishmaniasis, which is a serious disease in much of the Old World. Current treatments include a small number of antimony compounds that, while somewhat effective, are limited by serious side effects.
Stephanie, St George +3 more
openaire +2 more sources
Leishmania vaccines entered in clinical trials: A review of literature
International Journal of Preventive Medicine, 2019 Leishmaniasis is considered as a zoonotic infection and neglected tropical disease. Leishmania treatment is not totally successful and imposes high expenditures, especially in developing countries. Since the natural infection leads to the robust immunity
Mohammad Moafi +3 more
doaj +1 more source
Updates on Geographical Dispersion of Leishmania Parasites Causing Cutaneous Affections in Algeria
Pathogens, 2021 Leishmaniases are neglected tropical diseases of public health concern in Algeria. To update the geographical distribution of Leishmania spp. causing cutaneous affection, we examined a set of Giemsa-stained smears prepared from skin lesions of the ...
Arezki Izri +3 more
doaj +1 more source
Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]
, 2012 Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Afonso +58 more
core +1 more source
Functional analysis of Leishmania major cyclophilin
International Journal for Parasitology, 2008 A potent immunosuppressive drug cyclosporin A (CsA) is known to inhibit human cell infection by the pathogenic protozoan parasite Leishmania major both in vitro and in vivo. The proposed mechanism of action involves CsA binding to Leishmania major-expressed cyclophilin and subsequent down-regulation of signaling events necessary for establishing ...
Yurchenko, Vyacheslav +3 more
openaire +2 more sources
The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids. [PDF]
, 2017 Trypanosomatid protozoa are unusual eukaryotes that are well known for having unusual ways of controlling their gene expression. The lack of a refined mode of transcriptional control in these organisms is compensated by several post-transcriptional ...
Campbell, David A +3 more
core +2 more sources
The LPG1 gene family of Leishmania major [PDF]
Molecular and Biochemical Parasitology, 2004 In Leishmania major, the core of the abundant surface lipophosphoglycan (LPG) is structurally related to that of the smaller glycosylinositolphospholipids (GIPLs) in containing galactosylfuranose (Gal(f)) residues in a Gal(f) (beta1, 3)Man motif. However, deletion of the putative Gal(f)-transferase (Gal(f)T) LPG1 affected Gal(f) incorporation in LPG ...
Kai, Zhang +3 more
openaire +2 more sources