Results 31 to 40 of about 4,849,377 (223)

Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds. [PDF]

, 2009
Genome sequencing of Leishmania species that give rise to a range of disease phenotypes in the host has revealed highly conserved gene content and synteny across the genus.
Alasdair C Ivens, Ivens, Alasdair C, Maroof, Asher, Paul M Kaye, Depledge Daniel P., Depledge, DP, Ivens, AC, Depledge, Daniel P, Maroof Asher, Aziz Naveed, Evans, KJ, Smith, Deborah F, Kaye, PM, Maroof, A, Smith, DF, Aziz, Naveed, Daniel P Depledge, Naveed Aziz, Ivens Alasdair C., Asher Maroof, Krystal J Evans, Evans Krystal J., Kaye Paul M., Aziz, N, Evans, Krystal J, Smith Deborah F., Kaye, Paul M, Deborah F Smith   +27 more
core   +1 more source

Gelatin Zymography of Major Proteases in Exosomes of Leishmania major Promastigotes

Iranian Journal of Parasitology, 2023
Background: Enzymatic digestion of extra cellular matrix proteins by proteinases of   Leishmania promastigotes is a complex process. Hence, studies on functional proteomics of these enzymes can help select these enzymes as possible vaccine candidates or selecting candidates for chemotherapy and immunotherapy. Several proteolytic enzymes are involved in
Akram Azambakhtiar, Sedigheh Nabian, Mehdi Mohebali, Mohammad Taheri, Ramin Mazaheri Nezhad Fard   +4 more
openaire   +3 more sources

Changes in the Epidemiology of Cutaneous Leishmaniasis in Northeastern Iran

Türkiye Parazitoloji Dergisi, 2020
The province of Khorasan-Razavi in the North East of Iran is an endemic area for anthroponotic cutaneous leishmaniasis (ACL caused mainly by Leishmania tropica) and zoonotic cutaneous leishmaniasis (ZCL caused mainly by Leishmania major).
Bibi Razieh Hosseini Farash, Seyed Ali Akbar Shamsian, Masoud Mohajery, Abdolmajid Fata, Fatemeh Sadabadi, Fariba Berenji, Pietro Mastroeni, Elham Poustchi, Elham Moghaddas, Ghodratollah Salehi Sangani, Gholamreza Farnoosh   +10 more
doaj   +1 more source

Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019

International Journal of Infectious Diseases, 2022
: Objectives: Cutaneous leishmaniasis (CL) in Asia, Northern, and Sub-Saharan Africa is mainly caused by Leishmania major and Leishmania tropica. We describe and evaluate the treatment outcome of CL among travelers and migrants in Europe.
Hedvig Glans, Leif Dotevall, Gert Van der Auwera, Aldert Bart, Johannes Blum, Pierre Buffet, Romain Guery, Jean-Pierre Gangneux, Saskia van Henten, Gundel Harms, Stefania Varani, Florence Robert-Gangneux, Robert Rongisch, Björn Andersson, Maria Bradley   +14 more
doaj   +1 more source

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major [PDF]

, 2012
Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome ...
Williams, Roderick A M, Mottram, Jeremy C, Roderick A M Williams, Benjamin Cull, Mottram Jeremy C., Coombs, Graham H, Williams Roderick A. M., Cull Benjamin, Terry K Smith, Jeremy C. Mottram (112563), Graham H. Coombs (164011), Smith Terry K., Terry K. Smith (112550), Mottram, Jeremy C., Benjamin Cull (164010), Coombs Graham H., Coombs, Graham H., Smith, Terry K., Jeremy C Mottram, Smith, Terry K, Cull, Benjamin, Williams, Roderick A. M., Roderick A. M. Williams (164005), Graham H Coombs, Smith, Terry K.; id_orcid   +24 more
core   +1 more source

Histological and immunological differences between zoonotic cutaneous leishmaniasis due to Leishmania major and sporadic cutaneous leishmaniasis due to Leishmania infantum

Parasite, 2019
Lesion features in cutaneous leishmaniasis (CL) depend on the infecting Leishmania species as well as on host immune reponse. In this study, we evaluated the histological and immunological differences between two forms of CL described in Tunisia ...
Boussoffara Thouraya, Boubaker Mohamed Samir, Ben Ahmed Melika, Mokni Mourad, Guizani Ikram, Ben Salah Afif, Louzir Hechmi   +6 more
doaj   +1 more source

Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation [PDF]

, 2012
Leishmania ISPs are ecotin-like natural peptide inhibitors of trypsin-family serine peptidases, enzymes that are absent from the Leishmania genome. This led to the proposal that ISPs inhibit host serine peptidases and we have recently shown that ISP2 ...
Petr Volf, Mottram, Jeremy C, Gareth D. Westrop, Eschenlauer, Sylvain C, Volf, Petr, Amy Goundry, Sylvain C. Eschenlauer, Jeremy C. Mottram, Lima, Ana Paula C A, Lima, Ana Paula C.A., Morrison, Lesley S, Morrison, Lesley S., Lesley S. Morrison, Ana Paula C. A. Lima, Goundry, Amy, Faria, Marilia S, Marilia S. Faria, Graham H. Coombs, Westrop, Gareth D., Coombs, Graham H, Anna Dostalova, Laurence Tetley, Faria, Marilia S., Tetley, Laurence, Dostalova, Anna, Westrop, Gareth D, Mottram, Jeremy C., Eschenlauer, Sylvain C., Coombs, Graham H.   +28 more
core   +1 more source

Mixed Mucosal Leishmaniasis Infection Caused by Leishmania tropica and Leishmania major [PDF]

Journal of Clinical Microbiology, 2012
ABSTRACT Mixed infections with different Leishmania species could explain differences in the clinical courses of these infections. On identification of Leishmania parasites from Iranian patients with mucosal leishmaniasis (ML), a patient with both oral and nasal lesions was found to
Sadegh, Shirian, Ahmad, Oryan, Gholam Reza, Hatam, Yahya, Daneshbod   +3 more
openaire   +2 more sources

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase [PDF]

, 2011
Background: Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form ...
Walker, Roderick G., Brown, Elaine, Thomson, Graeme, Blake, David G., Malone, Kirk, Turner, Nicholas J., Grant, Karen, Mottram, Jeremy C., Walkinshaw, Malcolm D., Nowicki, Matthew W.   +9 more
core   +3 more sources

Antileishmanial activity of polycyclic derivatives

Parasite, 2005
33 polycyclic derivatives have been studied and tested on Leishmania donovani and L. major promastigotes. Their antileishmanial activity was assessed in vitro and an assay of their cytotoxicity was realized on human myelomonocytic cell line.
Sarciron M.E., Terreux R., Prieto Y., Cortes M., Cuellar M.A., Tapia R.A., Domard M., Walchshofer N., Pétavy A.F.   +8 more
doaj   +1 more source