Results 11 to 20 of about 9,977 (186)

Anti-Leishmanial Activity of Artemisia persica, A. spicigera, and A. fragrance against Leishmania major

Iranian Journal of Parasitology, 2021
Background: Neglected tropical diseases (NTDs) like zoonotic cutaneous leishmaniasis (ZCL), is a widespread infectious disease with high mortality and morbidity.
Mehdi Najm, Ramtin Hadighi, Maryam Heidari-Kharaji, Maryam Alipour, Maryam Hajizadeh, Raheleh Rafiei Sefiddashti, Aliehsan Heidari, Alireza Badirzadeh   +7 more
doaj   +1 more source

Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene [PDF]

, 2003
Leishmania parasites (order Kinetoplastida, family Trypanosomatidae) cause a spectrum of human diseases ranging from asymptomatic to lethal. The approximately 33.6 Mb genome is distributed among 36 chromosome pairs that range in size from approximately 0.
Fu, Guoliang, Schnaufer, Achim; id_orcid, Sisk, Ellen, Martinez-Calvillo, Santiago, Ivens, Alasdair C, Hixson, Greg, Aggarwal, Gautam, Fazelinia, Gholam, Fong, Chris, Sunkin, Susan M, Worthey, E A, Salavati, Reza, Hassebrock, Melissa, Marsolini, Felicia, Rickell, Erica, Kiser, Patti, Stuart, Kenneth D, Cawthra, Jason, Rickel, Erika, Myler, Peter J   +19 more
core   +1 more source

The LPG1 gene family of Leishmania major [PDF]

Molecular and Biochemical Parasitology, 2004
In Leishmania major, the core of the abundant surface lipophosphoglycan (LPG) is structurally related to that of the smaller glycosylinositolphospholipids (GIPLs) in containing galactosylfuranose (Gal(f)) residues in a Gal(f) (beta1, 3)Man motif. However, deletion of the putative Gal(f)-transferase (Gal(f)T) LPG1 affected Gal(f) incorporation in LPG ...
Kai, Zhang, Tamara, Barron, Salvatore J, Turco, Stephen M, Beverley   +3 more
openaire   +2 more sources

Separation and evaluation of natural antileishmanial potential against Leishmania major and infuntum isolated from the Tunisia strains

Bangladesh Journal of Pharmacology, 2018
Besides its nutritional value as a dietary supplement, Tribulus terrestris is used as a remedy for fertility disorder in Ayurveda and Chinese medicine as well as by modern herbalists.
Salwa Bouabdallah, Dhafer Laouini, Nabiha Bouzouita, Safia El-Bok, Rabiaa M. Sghaier, Sawssen Selmi, Mossadok Ben Attia   +6 more
doaj   +1 more source

Treatment Outcome of the Drug-resistant Zoonotic Cutaneous Leishmaniasis by Glucantime

Advanced Biomedical Research, 2017
Background: Resistance of Leishmania species to antimonial drugs has increased. Hence, in the present study Leishmania major isolates were collected from patients with resistance phenotype and the presence/absence of resistance to Glucantime was ...
Simindokht Soleimanifard, Reza Arjmand, Sedighe Saberi, Mansoor Salehi, Seyed Hossain Hejazi   +4 more
doaj   +1 more source

The Genome of the Kinetoplastid Parasite, Leishmania major [PDF]

Science, 2005
Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 ...
Ivens, A.C., Peacock, C.S., Worthey, E.A., Murphy, L., Aggarwal, G., Berriman, M., Sisk, E., Rajandream, M.A., Adlem, E., Aert, Rita, Anupama, A., Myler, P.J., Apostolou, Z., Attipoe, P., Bason, N., Bauser, C., Beck, A., Beverley, S.M., Bianchettin, G., Borzym, K., Bothe, G., Bruschi, C.V., Collins, M., Cadag, E., Ciarloni, L., Clayton, C., Coulson, R.MR., Cronin, A., Cruz, A.K., Davies, R.M., De Gaudenzi, J., Dobson, D.E., Duesterhoeft, A., Fazelina, G., Fosker, N., Frasch, A.C., Fraser, A., Fuchs, M., Gabel, C., Goble, A., Goffeau, A., Harris, D., Hertz-Fowler, C., Hilbert, H., Horn, D., Huang, Y.T., Klages, S., Knights, A., Kube, M., Larke, N., Litvin, L., Lord, A., Louie, T., Marra, M., Masuy, D., Matthews, K., Michaeli, S., Mottram, J.C., Muller-Auer, S., Munden, H., Nelson, S., Norbertczak, H., Oliver, K., O'Neil, S., Pentony, M., Pohl, T.M., Price, C., Purnelle, B., Quail, M.A., Rabbinowitsch, E., Reinhardt, R., Rieger, M., Rinta, J., Robben, Johan, Robertson, L., Ruiz, J.C., Rutter, S., Saunders, D., Schafer, M., Schein, J., Schwartz, D.C., Seeger, K., Seyler, A., Sharp, S., Shin, H., Sivam, D., Squares, R., Squares, S., Tosato, V., Vogt, C., Volckaert, Guido, Wambutt, R., Warren, T., Wedler, H., Woodward, J., Zhou, S.G., Zimmermann, W., Smith, D.F., Blackwell, J.M., Stuart, K.D., Barrell, B.   +100 more
openaire   +5 more sources

The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies [PDF]

, 2013
SUMMARY Binding of promastigotes to the sand fly midgut epithelium is regarded as an essential part of the Leishmania life cycle in the vector. Among Leishmania surface molecules putatively involved in attachment to the sand fly midgut, two GPI-anchored ...
Jecna, Lucie, Bates, Paul A., Seblova, Veronika, Volf, Petr, Dostalova, Anna, Chang, Kwang-Poo, LUCIE JECNA, VERONIKA SEBLOVA, PAUL A. BATES, PETR VOLF, ANNA DOSTALOVA, RAY WILSON, Wilson, Ray, KWANG-POO CHANG   +13 more
core   +1 more source

Structure ofLeishmania majorcysteine synthase [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2012
Cysteine biosynthesis is a potential target for drug development against parasiticLeishmaniaspecies; these protozoa are responsible for a range of serious diseases. To improve understanding of this aspect ofLeishmaniabiology, a crystallographic and biochemical study ofL.
Fyfe, Paul K, Westrop, Gareth D, Ramos, Tania, Müller, Sylke, Coombs, Graham H, Hunter, William N   +5 more
openaire   +5 more sources

Overview of the organization of protease genes in the genome of Leishmania spp

Parasites & Vectors, 2014
Background The genus Leishmania includes protozoan parasites that are able to infect an array of phlebotomine and vertebrate species. Proteases are related to the capacity of these parasites to infect and survive in their hosts and are therefore ...
Mariana Silva-Almeida, Franklin Souza-Silva, Bernardo Acácio Santini Pereira, Michelle Lopes Ribeiro-Guimarães, Carlos Roberto Alves   +4 more
doaj   +1 more source

Leishmania vaccines entered in clinical trials: A review of literature

International Journal of Preventive Medicine, 2019
Leishmaniasis is considered as a zoonotic infection and neglected tropical disease. Leishmania treatment is not totally successful and imposes high expenditures, especially in developing countries. Since the natural infection leads to the robust immunity
Mohammad Moafi, Hossein Rezvan, Roya Sherkat, Roya Taleban   +3 more
doaj   +1 more source