Results 71 to 80 of about 17,806 (239)

Sequence analysis of the 3-untranslated region of HSP70 (type I) genes in the genus Leishmania: Its usefulness as a molecular marker for species identification [PDF]

, 2015
Background: The Leishmaniases are a group of clinically diverse diseases caused by parasites of the genus Leishmania. To distinguish between species is crucial for correct diagnosis and prognosis as well as for treatment decisions.
Cañavate, Carmen, Chicharro, Carmen, García, Lineth, Parrado, Rudy, Puerta, Concepción J., Requena, José María   +5 more
core   +1 more source

Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives

ChemMedChem, Volume 20, Issue 16, August 16, 2025.
Based on previously identified antimalarial agents, a series of highly substituted pyrazole and pyrimidines derivatives has been synthesized and tested for antiplasmodial and antileishmanial activity. Selected derivatives show promising antiplasmodial effect with a predicted favorable pharmacokinetic profile.
Matteo Lusardi, Nicoletta Basilico, Erika Iervasi, Chiara Brullo, Silvia Parapini, Marco Ponassi, Camillo Rosano, Andrea Spallarossa   +7 more
wiley   +1 more source

Molecular detection of Leishmania species in human and animals from cutaneous leishmaniasis endemic areas of Waziristan, Khyber Pakhtunkhwa, Pakistan

Asian Pacific Journal of Tropical Medicine, 2018
Objectives: To detect Leishmania species in human patients, animal reservoirs and Phlebotomus sandflies in Waziristan, Pakistan. Methods: Tissue smears and aspirates from 448 cutaneous leishmaniasis (CL) suspected patients were analyzed. To sort out role
Mubashir Hussain, Shahzad Munir, Abdullah Jalal, Taj Ali Khan, Niaz Muhammad, Bahar Ullah Khattak, Abdullah Khan, Irfan Ahmed, Zulqarnain Baloch, Nawaz Haider Bashir, Muhammad Ameen Jamal, Kashif Rahim, Humaira Mazhar, Maira Riaz, Noha Watany   +14 more
doaj   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

IL‐12 and IFN‐γ in Response to Leishmania Infantum Antigens in Felines From an Endemic Area for Visceral Leishmaniasis

Parasite Immunology, Volume 47, Issue 8, August 2025.
ABSTRACT Visceral leishmaniasis is a potentially fatal zoonosis with an increasing incidence. Most infected felines present the disease in its subclinical form and demonstrate greater resistance to parasitemia than dogs. However, the role of cellular immunity in felines is still poorly understood. This study measured serum levels of interleukin (IL)‐12
João Victor Lé Lode, Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Valéria Marçal Felix de Lima   +3 more
wiley   +1 more source

Incidence of Trypanosoma cruzi infection in two Guatemalan communities.

, 2004
The prevalence of human infection by Trypanosoma cruzi was assessed using an enzyme-linked immunosorbent assay (ELISA) in a serological survey in 1998 of 2 rural communities (SMH and PS) in Guatemala.
Davies, C, Lines, J, Monroy, C, Paz-Bailey, G, Rodas, A, Rosales, R, Tabaru, R   +6 more
core   +1 more source

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. [PDF]

, 1994
Leishmania major are intramacrophage parasites whose eradication requires the induction of T helper 1 (Th1) effector cells capable of activating macrophages to a microbicidal state.
Locksley, RM, Reiner, SL, Stowring, L, Wang, ZE, Zheng, S   +4 more
core   +1 more source

Leishmania tropica

, 2010
Cutaneous Leishmaniasis (CL), or oriental sore, is mainly caused by Leishmania tropica and L. major in the Old World. CL due to L. tropica has become a major public health problem in different endemic foci due to recent outbreaks in several urban areas. The disease caused by L. tropica presents varying clinical manifestations and complications.
openaire   +2 more sources

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Anti-leishmania Effect of Magnesium Oxide Nanoparticles on Leishmania tropica/infantum and Leishmania-Infected Macrophages [PDF]

, 2022
Amir KarimiPourSaryazdi, Mohammad Mahdi Jafari, Roya Omidi, Fatemeh Ghaffarifar, Seyyed Hojjat Sadeghi   +4 more
openalex   +1 more source