Results 71 to 80 of about 17,469 (165)

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Epidemiological aspects of the first human autochthonous visceral leishmaniosis cases in Porto Alegre, Brazil

Brazilian Journal of Infectious Diseases, 2019
Human visceral leishmaniasis is a growing anthropozoonosis in Brazil, and particularly in the southern region of the country. It is an infectious disease transmitted to humans, dogs and other animals in urban and rural areas of the Americas, mainly due ...
Ibrahim Clós Mahmud, Letícia de Araujo Saraiva Piassini, Fabrizio Motta, Paulo Renato Petersen Behar, Getúlio Dornelles Souza   +4 more
doaj  

Leishmaniasis visceral canina

Revista MVZ Córdoba, 2000
La leishmaniasis visceral canina (LVC), producida por Leishmania infantum (=Leishmania chagasi) es una patología infecciosa zoonótica de importancia para la salud pública en países del Nuevo y Viejo Mundo. En Colombia se la encuentra distribuida en varios focos donde predomina el bosque seco tropical (Corredor et al., 1989).
openaire   +4 more sources

Drug Resistance in Visceral Leishmaniasis [PDF]

Journal of Biomedicine and Biotechnology, 2010
Visceral leishmaniasis remains a public health problem worldwide. This illness was included by the World Health Organization in the list of neglected tropical diseases targeted for elimination by 2015. The widespread emergence of resistance to pentavalent antimonials in India where half cases occur globally and the unavailability of a vaccine in ...
openaire   +3 more sources

Leishmaniasis in rheumatoid arthritis

Reumatismo, 2011
Leishmaniasis represents a complex of diseases with an important clinical and epidemiological diversity. Visceral leishmaniasis is of higher priority than cutaneous leishmaniasis as it is a fatal disease in the absence of treatment. The clinical spectrum
M. Cutolo, M.E. Secchi, C. Pizzorni
doaj   +1 more source

Pediatric visceral leishmaniasis in Albania

International Journal of Infectious Diseases, 2002
Visceral leishmaniasis (VL) in children is endemic in southern Europe but has not been previously reported from Albania. This prospective study reports the clinical and laboratory findings in 50 children with visceral leishmaniasis, the value of a direct agglutination test (DAT), and the result of treatment with meglumine antimonate.Sera obtained from ...
G. Sulcebe, Farzin Davachi, Mira Basha, Hamaide Bregu, Gjeorgjina Lito   +4 more
openaire   +3 more sources

Leishmaniasis in the Argentine Republic: Temporal and geographical distribution from 2013 to 2017

Asian Pacific Journal of Tropical Medicine, 2019
Objective: To assess the temporal and geographical distribution of confirmed cases of cutaneous, mucocutaneous and visceral leishmaniasis in the Argentine Republic from 2013 to 2017.
María J Germano, María C Salomón, Gisela Neira, Esteban Lozano, Juan P Mackern-Oberti, Diego E Cargnelutti   +5 more
doaj   +1 more source

[Spatial-temporal distribution of visceral leishmaniasis in Brazil from 2007 to 2020Distribución espaciotemporal de la leishmaniasis visceral en Brasil en el período 2007-2020]. [PDF]

Rev Panam Salud Publica, 2023
Nina LNDS, Caldas AJM, Soeiro VMDS, Ferreira TF, Silva TC, Rabelo PPC.   +5 more
europepmc   +1 more source

Alteration of Clinical Chemistry Parameters Among Visceral Leishmaniasis Patients in Western Tigrai, Ethiopia, 2018/2019: A Comparative Cross-Sectional Study

Infection and Drug Resistance, 2020
Brhane Tesfanchal,1 Gebremedhin Gebremichail,2 Getachew Belay,1 Gebreslassie Gebremariam,3 Gebreyohannes Teklehaimanot,4 Hagos Haileslasie,2 Getachew Kahsu,1 Aderajew Gebrewahd,5 Fitsum Mardu,6 Gebre Adhanom,5 Brhane Berhe,6 Hirut Teame,7 Aster Tsegaye,8
Tesfanchal B, Gebremichail G, Belay G, Gebremariam G, Teklehaimanot G, Haileslasie H, Kahsu G, Gebrewahd A, Mardu F, Adhanom G, Berhe B, Teame H, Tsegaye A, Wolde M   +13 more
doaj  

Interstitial pneumonitis in canine visceral leishmaniasis

Revista do Instituto de Medicina Tropical de São Paulo, 1986
Forty-one naturally infected dogs with visceral leishmaniasis from an urban area of Corumbá (Mato Grosso do Sul-BRAZIL) were studied and three types of lung involvement due to visceral leishmaniasis were characterized; a cellular, a cellular-fibrotic and
M. I. S. Duarte, M. D. Laurenti, V. L. Brandão Nunes, A. F. Rego Jr., E. T. Oshiro, C. E. P. Corbett   +5 more
doaj   +1 more source