Results 71 to 80 of about 135,267 (266)

Identification of CβS and ODC antimony resistance markers in anthroponotic cutaneous leishmaniasis field isolates by gene expression profiling

Parasite Epidemiology and Control
Antiparasitic resistance represents a serious global public health concern with tremendous economic and safety implications. This study intended to investigate the expression of the two major resistant markers: cystathionine β synthase (CβS) and ...
Farzaneh Zarrinkar, Iraj Sharifi, Razieh Tavakoli Oliaee, Ali Afgar, Elaheh Molaakbari, Mehdi Bamorovat, Zahra Babaei, Ebrahim Eskandari, Ehsan Salarkia, Marzieh Asadi   +9 more
doaj   +1 more source

A Multi-Country, Single-Blinded, Phase 2 Study to Evaluate a Point-of-Need System for Rapid Detection of Leishmaniasis and Its Implementation in Endemic Settings [PDF]

, 2021
Prakash Ghosh, Abhijit Sharma, Narayan Raj Bhattarai, Kumar Abhishek, Thilini Nisansala, Amresh Kumar, Susanne Böhlken-Fascher, Rajashree Chowdhury, Md Anik Ashfaq Khan, Khaledul Faisal, Faria Hossain, Md. Rasel Uddin, Md. Utba Rashid, Shomik Maruf, Keshav Rai, Monica Sooriyaarachchi, Withanage Lakma Kumari Abhayarathna, Prahlad Karki, Shiril Kumar, Shalindra Ranasinghe, Basudha Khanal, Satyabrata Routray, Pradeep Das, Dinesh Mondal, Ahmed Abd El Wahed   +24 more
openalex   +1 more source

Defensive medicine in dermatological practice – Dermatopathology as a mirror of structural challenges

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Defensive medicine refers to diagnostic or therapeutic actions taken primarily to reduce legal liability rather than to benefit the patient. In dermatopathology, defensive practices manifest in frequent immunohistochemical testing, overly cautious report phrasing, and reliance on multidisciplinary tumor boards.
Cornelia Sigrid Lissi Müller, Torsten Hansen, Claus Renzelmann   +2 more
wiley   +1 more source

Detection of asymptomatic Leishmania infection in Bangladesh by antibody and antigen diagnostic tools shows an association with post–kala-azar dermal leishmaniasis (PKDL) patients [PDF]

, 2021
Sophie I. Owen, Faria Hossain, Prakash Ghosh, Rajashree Chowdhury, Md. Sakhawat Hossain, Chris Jewell, Israel Cruz, Albert Picado, Dinesh Mondal, Emily R. Adams   +9 more
openalex   +1 more source

Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis

European Journal of Clinical Investigation, EarlyView.
Controlled Human Infection Models (CHIMs) offer a powerful approach to accelerate vaccine development for neglected tropical diseases (NTDs). This review highlights scientific and translational advances enabled by CHIMs, with a focus on a novel Leishmania major model.
Vivak Parkash
wiley   +1 more source

RTS,S/AS02 and the quest of the Holy Grail [PDF]

, 2002
High-profile programs under the WHO/Roll Back Malaria initiative, in addition to unravelling the human and malaria parasite genomes, have ensured that malaria vaccine research and development are enjoying an unprecedented boom. So far, the development of
Reithinger, R
core  

Predicting the distribution of canine leishmaniasis in western Europe based on environmental variables. [PDF]

, 2011
The domestic dog is the reservoir host of Leishmania infantum, the causative agent of zoonotic visceral leishmaniasis endemic in Mediterranean Europe. Targeted control requires predictive risk maps of canine leishmaniasis (CanL), which are now explored ...
ADRIAN MYLNE, ANA O. FRANCO, CARLOS ALVES PIRES, CLIVE R. DAVIES, CRISTINA BALLART, FRANCISCO MORILLAS-MÁRQUEZ, Hastie, JEAN-PIERRE DEDET, JONATHAN COX, LUIGI GRADONI, MARIA ODETE AFONSO, MARINA GRAMICCIA, MONTSERRAT GÁLLEGO, PAUL D. READY, Rabe-Hesketh, Ready, Ribeiro, RICARDO MOLINA, Rioux, Rogers, ROSA GÁLVEZ, SERGIO BARÓN-LÓPEZ   +21 more
core   +2 more sources

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Leishmania donovani's protein tyrosine phosphatases interact with DUF21 and respond to environmental magnesium

The FEBS Journal, EarlyView.
The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini, Hira Khursheed, Wen Wei Zhang, Isabelle Aubry, Greg Matlashewski, Michel L. Tremblay, Patrick Lypaczewski   +6 more
wiley   +1 more source

Atypical presentation of visceral leishmaniasis from non-endemic region [PDF]

, 2010
A case of atypical and acute presentation of visceral leishmaniasis from non-endemic region, characterised by exudative pleural effusion and hepatitis is ...
Gupta, D, Kashyap, R, Kaul, R, Raina, S
core   +1 more source