Results 131 to 140 of about 199,900 (336)

830. Highly Efficient and Comprehensive Gene Transfer to All Muscle Groups Necessary for the Potential Treatment of Duchenne/Becker Muscular Dystrophies Following In Utero Delivery of a Lentivirus Vector in Immuno-Competent Mice [PDF]

, 2003

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YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Discovery of a stable expression hot spot in the genome of Chinese hamster ovary cells using lentivirus-based random integration

Biotechnology & Biotechnological Equipment, 2019
The conventional method for construction of stable expression cell lines is mainly based on random integration. However, one drawback of random integration is that the target gene might be integrated into a heterochromatin region or an unstable region of
Songtao Zhou, Xuefeng Ding, Lei Yang, Yun Chen, Xiaohai Gong, Jian Jin, Huazhong Li   +6 more
doaj   +1 more source

Cas9+ conditionally-immortalized macrophages as a tool for bacterial pathogenesis and beyond. [PDF]

, 2019
Macrophages play critical roles in immunity, development, tissue repair, and cancer, but studies of their function have been hampered by poorly-differentiated tumor cell lines and genetically-intractable primary cells.
Barton, Gregory M, Ching, Krystal L, Cox, Jeffery S, Golovkine, Guillaume, Licht, Daniel J, Mitchell, Gabriel, Popov, Lauren M, Roberts, Allison W   +7 more
core  

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, EarlyView.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

Bayesian Estimation of the True Prevalence of Caprine Arthritis Encephalitis in Hungarian Goat Herds

Viruses
Background: Caprine arthritis encephalitis (CAE) is a major viral disease of goats, caused by small ruminant lentivirus (SRLV), associated with chronic arthritis, mastitis, pneumonia, and encephalitis, leading to economic losses and reduced animal ...
Krisztina Bárdos, Marietta Máté, Katalin Veres, Zsolt Lang, Giuseppe Bertoni, Carlos Eduardo Abril, Snorre Stuen, Saulius Petkevičius, Marcin Mickiewicz, Michał Czopowicz, Jarosław Kaba, László Ózsvári   +11 more
doaj   +1 more source

Effects of lentivirus‐mediated CREB expression in the dorsolateral striatum: Memory enhancement and evidence for competitive and cooperative interactions with the hippocampus [PDF]

, 2013
Balachandar Kathirvelu, Paul J. Colombo
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Development of a lentivirus-mediated gene therapy targeting HIV-1 RNA to eliminate HIV-1-infected cells

, 2022
Amanda B. Buckingham, Sophia Ho, Hoi-Ping Mok, Carin K. Ingemarsdotter, Andrew Lever   +4 more
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