Results 111 to 120 of about 166,720 (266)

Bayesian Estimation of the True Prevalence of Caprine Arthritis Encephalitis in Hungarian Goat Herds

Viruses
Background: Caprine arthritis encephalitis (CAE) is a major viral disease of goats, caused by small ruminant lentivirus (SRLV), associated with chronic arthritis, mastitis, pneumonia, and encephalitis, leading to economic losses and reduced animal ...
Krisztina Bárdos, Marietta Máté, Katalin Veres, Zsolt Lang, Giuseppe Bertoni, Carlos Eduardo Abril, Snorre Stuen, Saulius Petkevičius, Marcin Mickiewicz, Michał Czopowicz, Jarosław Kaba, László Ózsvári   +11 more
doaj   +1 more source

The effect of Id1 gene silencing on the neural differentiation of MSCs

Biotechnology & Biotechnological Equipment, 2017
We aimed to construct a highly efficient, lentivirus-mediated vector for RNA interference (RNAi) silencing of the Id1 gene and to examine whether silencing of this gene promotes the neural differentiation of mesenchymal stem cells (MSCs).
Xiao-qing Song, Li-ning Su, Hui-ping Wei, Ying-hui Liu, Hai-feng Yin, Ji-hong Li, Deng-xiang Zhu, Ai-lan Zhang   +7 more
doaj   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

A Novel Self-Replicating Chimeric Lentivirus-Like Particle

, 2012
Successful live attenuated vaccines mimic natural exposure to pathogens without causing disease and have been successful against several viruses. However, safety concerns prevent the development of attenuated human immunodeficiency virus (HIV) as a ...
Johnston, R. E., Victoria J. Madden, Johnson, P. R., Christy K. Jurgens, Jurgens, C. K., Kelly R. Young, Madden, V. J., Robert E. Johnston, Young, K. R., Philip R. Johnson   +9 more
core   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Labeled Purkinje cell axonal boutons after FL lentivirus injections.

, 2016
Labeled Purkinje cell axonal boutons after FL lentivirus injections.
Ryuichi Shigemoto (90312), Akiya Watakabe (304124), Hitomi Matsuno (701661), Soichi Nagao (189660), Moeko Kudoh (265843), Tetsuo Yamamori (105711)   +5 more
core   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Lentivirus infection and transduction in UM-SCC- cell line.

, 2014
Lentivirus infected cells showing the GFP expression in UM-SCC-47. (A) Histograms of the scrambled control (sr control) and (B) RhoC knockdown (RhoC kd) obtained by flowcytometry. (C) Negative control. Representation of the GFP expression in fluorescence
Theodoros N. Teknos (162909), Mozaffarul Islam (522454), Smita Sharma (522455)   +2 more
core   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source