Results 91 to 100 of about 166,720 (266)
Cell line with integrated reporter lentivirus vector.
, 2013 (a) Schematic of the reporter lentivirus. (b) Immunofluorescence imaging of cells 3 days post transduction (dpt) with reporter lentivirus, with or without MG132 for 3 or 7 h. (c) Flow cytometry of the cells from panel b after 7 h treatment with MG132. (d)
Keith R. Jerome (356247) +5 more
core +1 more source
Lentiviral-Mediated Transgene Expression Can Potentiate Intestinal Mesenchymal-Epithelial Signaling
Biological Procedures Online, 2009 Mesenchymal-epithelial signaling is essential for the development of many organs and is often disrupted in disease. In this study, we demonstrate the use of lentiviral-mediated transgene delivery as an effective approach for ectopic transgene expression ...
Kohn Aimee +3 more
doaj
Retrovirus Infections and Brazilian Wild Felids
Brazilian Journal of Veterinary Pathology, 2008 Feline leukemia virus (FeLV) and Feline immunodeficiency virus (FIV) are two retroviruses that are deadly to the domestic cat (Felis catus) and important to the conservation of the threatened wild felids worldwide.
Claudia Filoni +3 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity
Advanced Science, EarlyView.This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu +16 more
wiley +1 more source
Advanced Science, EarlyView.Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang +6 more
wiley +1 more source
, 2016 Analysis of mouse GCs cell cycle by FACS at 48 h post-trasnsfection with a shLuman lentivirus and a shRNA-negative lentivirus (mean ± SEM, n = 3).
Nan Wang (21935) +6 more
core +1 more source
Lentiviral Vectors and Cystic Fibrosis Gene Therapy
Viruses, 2010 Cystic fibrosis (CF) is a chronic autosomic recessive syndrome, caused by mutations in the CF Transmembrane Conductance Regulator (CFTR) gene, a chloride channel expressed on the apical side of the airway epithelial cells.
Massimo Conese, Stefano Castellani
doaj +1 more source
Ultrasound‐Actuated Gene Editing in Human Kidney Organoids
Advanced Science, EarlyView.Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller +6 more
wiley +1 more source