Results 251 to 260 of about 172,662 (343)

ZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis. [PDF]

Nat Aging
Wang K, He W, Gong Z, Gao J, Gao T, Pan N, Wu D, Yang Y, Li Z, Zhao X, Ji M, Shen S.   +11 more
europepmc   +1 more source

Lentivirus restriction by diverse primate APOBEC3A proteins

, 2013
Kimberly Schmitt, Kejun Guo, Miki Katuwal, Darayu Wilson, Courtney Prochnow, Ronda Bransteitter, Xiaojiang S. Chen, Mario L. Santiago, Edward B. Stephens   +8 more
openalex   +2 more sources

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

miR-101/METTL3 axis induces autophagy by interrupting FOXG1/EIF3J-AS1 binding in gliomas. [PDF]

Cell Death Dis
Yan Y, Liu S, Luo A, Cai M, Zhang X, Liu X, Xu Y, Su Y, Zhang S, Liu J, Liu X.   +10 more
europepmc   +1 more source

Interference of Vaccination against Bluetongue Virus Serotypes 1 and 8 with Serological Diagnosis of Small-Ruminant Lentivirus Infection

, 2011
Stephen Valas, A. Le Ven, Benoit Croisé, Maud Maquigneau, Cécile Perrin   +4 more
openalex   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Cigarette smoke-induced circFOXO3 upregulation enhances autophagy-regulated senescence of type II alveolar cells through interacting with E2F1. [PDF]

Tob Induc Dis
Zhou X, Wang Y, Lu J, Wang B, Zhou F, Pan J, Zhou L, Du C.   +7 more
europepmc   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Calpain-1 Potentiates Periodontal Regeneration via PHLPP1-ERK-Driven Osteogenesis in Periodontal Ligament Stem Cells. [PDF]

Int Dent J
Li Y, Yang B, Mei Z, Deng P, Fu T, Li J.
europepmc   +1 more source

High frequencies of resting CD4 ⁺ T cells containing integrated viral DNA are found in rhesus macaques during acute lentivirus infections

, 2009
Yoshiaki Nishimura, Reza Sadjadpour, Joseph J. Mattapallil, Tatsuhiko Igarashi, Wendy Lee, Alicia Buckler‐White, Mario Roederer, Tae‐Wook Chun, Malcolm A. Martin   +8 more
openalex   +1 more source