Results 91 to 100 of about 87,400 (287)

Replacement of feline foamy virus bet by feline immunodeficiency virus vif yields replicative virus with novel vaccine candidate potential

Retrovirology, 2018
Background Hosts are able to restrict viral replication to contain virus spread before adaptive immunity is fully initiated. Many viruses have acquired genes directly counteracting intrinsic restriction mechanisms.
Carmen Ledesma-Feliciano, Sarah Hagen, Ryan Troyer, Xin Zheng, Esther Musselman, Dragana Slavkovic Lukic, Ann-Mareen Franke, Daniel Maeda, Jörg Zielonka, Carsten Münk, Guochao Wei, Sue VandeWoude, Martin Löchelt   +12 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Small scale Lentivirus Production and Infection v1

, 2022
This protocol can be used for production and transduction of lentiviral sgRNA, shRNA and protein overexpression in conjunction with generation 2 and generation 3 lentivirus plasmids.
Herschel Dhekne, Suzanne R Pfeffer
openaire   +1 more source

Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection

, 2010
Although a variety of genetic strategies have been developed to inhibit HIV replication, few direct comparisons of the efficacy of these inhibitors have been carried out.
Stephen E. Braun, Berger Annemarie, John J Rossi, Stephen E Braun, Kimpel, Janine, Conolle Michelle, Annemarie Berger, R Paul Johnson, Schmitz, Jörn E., Qiu Gang, Schmitz Jörn E., Qiu, Gang, John J. Rossi, Dorothee von Laer, Wong Fay Eng, Laer, Dorothee von, Boro Dropulic, Humeau, Laurent M., Humeau Laurent M., Christian Brendel, Conolle, Michelle, Brendel Christian, Michelle Conolle, Laurent M Humeau, Braun, Stephen E., Brendel, Christian, Jörn E Schmitz, Wong, Fay Eng, Janine Kimpel, Gang Qiu, Dropulic Boro, von Laer Dorothee, Berger, Annemarie, Jörn E. Schmitz, R. Paul Johnson, Rossi, John J., Rossi John J., Laurent M. Humeau, Fay Eng Wong, Johnson, R. PauL, Kimpel Janine, Braun Stephen E., Johnson R. Paul, Dropulic, Boro   +43 more
core   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Vaccine-induced enhancement of viral infections

, 2009
Examples of vaccine-induced enhancement Of Susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different Virus families.
R.A. Gruters, W. Huisman, B.E.E. Martina, Gruters, Rob; id_orcid, Rimmelzwaan, Guus, G.F. Rimmelzwaan, A.D.M.E. Osterhaus, Martina, Byron, Huisman, W (Willem), Osterhaus, Ab   +9 more
core   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo.

PLoS Pathogens, 2010
Chronic immune activation and inflammation (e.g., as manifest by production of type I interferons) are major determinants of disease progression in primate lentivirus infections.
Cheryl A Stoddart, Mary E Keir, Joseph M McCune   +2 more
doaj   +1 more source

Bases moléculaires des maladies liées aux lentivirus

, 1996
Lentiviruses are a family of non oncogenic retroviruses that infect humans and animals. They induce chronic inflammatory and/or degenerative diseases of the lung, mammary gland, joints and central nervous System (table 1).
Levrey, Hélène, Mornex, Jean-François, Leroux, Caroline, Legastelois, Isabelle   +3 more
core  

Foci of endemic simian immunodeficiency virus infection in wild-living eastern chimpanzees (Pan troglodytes schweinfurthii) [PDF]

, 2003
Simian immunodeficiency virus of chimpanzees (SlVcpz) is the immediate precursor to human immunodeficiency virus type 1 (HIV-1), yet remarkably, the distribution and prevalence of SlVcpz in wild ape populations are unknown.
Heeney, J.L., Wrangham, R.W., Bibollet-Ruche, F, Kamenya, S, Shaw, G M, Lukasik, M, Pusey, A.E., Goodall, J., Li, Y., Shaw, G.M., Collins, D A, Lwanga, J S, Santiago, M L, Heeney, J L, Hahn, B.H., Brookfield, J F Y, Lwanga, J.S., Wrangham, R W, Bailes, E, Lukasik, M., Watts, D P, Goldenberg, D.A., Li, Y Y, Muller, M N, McClure, H M, Anthony Collins, D., Ayouba, A, McClure, H.M., Muller, M.N., Sharp, P M, Brookfield, J.F.Y., Bailes, E., Santiago, M.L., Nerrienet, E., Nerrienet, E, Emery, M., Kamenya, S., Goldenberg, D A, Goodall, J, Emery, M, Sharp, P.M., Bibollet-Ruche, F., Pusey, A E, Hahn, B H, Ayouba, Ahidjo, Watts, D.P.   +45 more
core   +1 more source