Results 151 to 160 of about 62,168 (302)
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source
Cancer Science, EarlyView.Using bioinformatic analysis, LCSC models, and transgenic mice, we demonstrate that co‐inhibition of Wnt3a and Loxl2 potently triggers ferroptosis and inhibits orthotopic liver tumorigenesis. The enhanced antitumor effect upon dual targeting, mediated through ZEB1 upregulation, highlights a promising combinatory approach against HCC.
Guanghui Ren +6 more
wiley +1 more source
Production of lentivirus carrying green fluorescent protein with different promoters for in vitro gene transfer [PDF]
, 2012 Many diseases are potential targets for gene therapy using either non-viral or viral vectors. Unlike non-viral methods, viral vectors, such as lentiviruses, have the ability to integrate into the host chromosome, which can lead to long-term transgene ...
Abdullah, Syahril +2 more
core
Amplicon sequencing with Oxford nanopore technologies as a diagnostic alternative for small ruminant lentiviruses in sheep [PDF]
Magdalena Serrano +7 more
openalex +3 more sources
Cancer Science, EarlyView.Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka +4 more
wiley +1 more source
BOLL‐Containing Aggregates Mediate the Translational Regulation During Human Oogenesis
Cell Proliferation, EarlyView.This work elucidates that BOLL‐containing aggregate‐mediated translational control is essential for human oogenesis. These aggregates recruit PABPC1 and FXR1 to activate the translation of U‐rich mRNAs encoding cell cycle proteins, thereby ensuring successful meiotic progression.
Ying Li +5 more
wiley +1 more source
Transmissão interespécie dos lentivírus de pequenos ruminantes: revisão e desafios. [PDF]
, 2016 Resumo: A artrite-encefalite caprina (CAE) e a Maedi-Visna (MV) são doenças de curso progressivo, que acometem caprinos e ovinos, respectivamente. Durante anos, o agente etiológico viral dessas enfermidades era considerado como específico a cada espécie.
COSTA, J. N. +3 more
core
Diagnostic performance of ID Screen® MVV-CAEV Indirect Screening ELISA in identifying small ruminant lentiviruses-infected goats [PDF]
, 2014 Dorota Nowicka +6 more
openalex +1 more source
European Journal of Haematology, EarlyView.SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley +1 more source
Retargeting Lentiviruses via SpyCatcher-SpyTag Chemistry for Gene Delivery into Specific Cell Types [PDF]
, 2017 Nagarjun Kasaraneni +3 more
openalex +1 more source