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A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca Lepidium meyenii [PDF]

Current Issues in Molecular Biology
Glioblastoma multiforme (GBM) is one of the most aggressive and treatment-resistant forms of brain cancer. Current therapeutic strategies, including surgery, chemotherapy, and radiotherapy, often fail due to the tumor’s ability to develop resistance. The
Albert Gabriel Turpo-Peqqueña, Sebastian Luna-Prado, Renato Javier Valencia-Arce, Fabio Leonardo Del-Carpio-Carrazco, Badhin Gómez   +4 more
doaj   +3 more sources

Exploring the chemical and pharmacological variability of Lepidium meyenii: a comprehensive review of the effects of maca [PDF]

Frontiers in Pharmacology
Maca (Lepidium meyenii), a biennial herbaceous plant indigenous to the Andes Mountains, has a rich history of traditional use for its purported health benefits.
Norka Ulloa del Carpio, Diego Alvarado-Corella, Dante M. Quiñones-Laveriano, Andrea Araya-Sibaja, José Vega-Baudrit, Maria Monagas-Juan, Mirtha Navarro-Hoyos, Martha Villar-López, Martha Villar-López   +8 more
doaj   +3 more sources

Phytochemical Evaluation of Lepidium meyenii, Trigonella foenum-graecum, Spirulina platensis, and Tribulus arabica, and Their Potential Effect on Monosodium Glutamate Induced Male Reproductive Dysfunction in Adult Wistar Rats [PDF]

Antioxidants
Monosodium glutamate (MSG), a sodium salt derived from glutamic acid, is widely used in commercial food products to improve taste, quality, and preservation.
Naglaa Gamil Shehab, Temidayo S. Omolaoye, Stefan S. Du Plessis, Surendra Singh Rawat, Nerissa Naidoo, Kholoud Y. Abushawish, Ayat Ahmed, Baraa Alaa, Heba Ihsan, Manar Abdelhalim, Mariam Ayman, Eslam El Nebrisi   +11 more
doaj   +3 more sources

Lepidium meyenii (Maca) – multidirectional health effects – review [PDF]

Current Issues in Pharmacy and Medical Sciences, 2018
Lepidium meyenii, commonly known as Maca, is a Peruvian plant that grows high in the Andes, in areas over 4,000 meters above sea level. Its composition contains almost all of the essential amino acids and twenty of the essential fatty acids needed by man,
Kasprzak Dorota, Jodlowska-Jedrych Barbara, Borowska Katarzyna, Wojtowicz Agnieszka   +3 more
doaj   +5 more sources

The effects of Lepidium meyenii on MSG-induced subfertility in male Wistar rats: Targeting oxidative stress, pro-inflammatory cytokines, steroidogenic enzymes, and reproductive hormones regulation [PDF]

Heliyon
Objective and rationale: Although monosodium glutamate (MSG), commonly used to enrich food flavour, is generally considered safe for consumption, evidence has shown its adverse effects on physiological functions, including male reproduction, when ...
Temidayo S. Omolaoye, Surendra Singh Rawat, Naglaa Gamil Shehab, Eslam El Nebrisi, Stefan S. Du Plessis   +4 more
doaj   +3 more sources

Maca (Lepidium meyenii Walp.) on semen quality parameters: A systematic review and meta-analysis [PDF]

Frontiers in Pharmacology, 2022
Background: This study aimed to examine the evidence for the effect of Lepidium meyenii Walp. [Brassicaceae] (L. meyenii W.), known as maca, on improving semen quality.Methods: Nine databases were searched for randomized controlled trials (RCTs) that ...
Hye Won Lee, Myeong Soo Lee, Fan Qu, Je-Won Lee, Eunseop Kim   +4 more
doaj   +2 more sources

Global Research Status of Maca (<i>Lepidium Meyenii</i> Walp.): A Bibliometric Analysis of Hotspots, Bursts, and Trends. [PDF]

Drug Des Devel Ther
Purpose This bibliometric study aims to comprehensively analyze the research landscape of Maca (Lepidium meyenii Walp.) from 2003 to 2024, identifying key research areas, trends, and patterns, as well as the roles of major countries and institutions in ...
Li K, Zhao C, Dang M, Ren R, Fu M, Bai Y, Wang J, Zhang Q, Luan F.   +8 more
europepmc   +2 more sources

The Effects of Peruvian maca (<i>Lepidium meyenii</i>) Root Extract on In Vitro Cultured Porcine Fibroblasts and Adipocytes. [PDF]

Molecules
Peruvian maca (Lepidium meyenii) is a plant known for its nutritional and medicinal properties whose use as a supplement in animal diets has attracted much interest. We studied the effects of powdered maca root extract on the growth potential of in vitro
Loba-Pasternak W, Aksoy MO, Stuper-Szablewska K, Szwajkowska-Michalek L, Kolodziejski P, Szczerbal I, Nowacka-Woszuk J.   +6 more
europepmc   +2 more sources

<i>Lepidium meyenii</i> Walpers Promotes the Regeneration of Salivary Gland and Prevents Xerostomia After Irradiation Injury. [PDF]

Nutrients
Objectives: Lepidium meyenii Walpers (LMW), a high-altitude plant, is known to stimulate hormone release, counteract neurodegeneration, and protect against oxidative stress.
Tsai YT, Lin YC, Cheng MJ, Shih CM, Tsai CS, Lai ZH, Wu CY, Liu CW, Lin FY, Lin YW.   +9 more
europepmc   +2 more sources

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng) [PDF]

Plants, 2021
Background: In the 1960s, research into plant adaptogens began. Plants with adaptogenic properties have rich phytochemical compositions and have been used by humanity since ancient times.
Velislava Todorova, Kalin Ivanov, Stanislava Ivanova   +2 more
doaj   +2 more sources