Results 131 to 140 of about 151,999 (312)

Peripheral Sympathetic Leptin Receptor Signaling Regulates Sympathetic Innervation of White Adipose Tissue and Diet-Induced Thermogenesis

The rising prevalence of obesity poses a significant public health challenge, with profound implications for metabolic disorders and associated health risks. In the United States, approximately 40% of adults are considered obese.
Silva, Felipe C
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Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome

, 2002
Background: Obesity in Prader-Willi syndrome (PWS) may be related to abnormalities in the adipocyte-leptin-hypothalamic pathway and may be exacerbated by reductions in the resting metabolic rate (RMR).
Mohammad A Ghatei, Brynes, A.E., Thomas, E.L., Frost, G.S., Bloom, S.R., Goldstone, A.P., Gary Frost, Audrey E Brynes, Bell, J.D., E Louise Thomas, Stephen R Bloom, Jimmy D Bell, Anthony Holland, Anthony P Goldstone, Holland, A., Ghatei, M.A.   +15 more
core   +1 more source

LEPTIN AND OBESITY – NEUROENDOCRINE , METABOLIC AND ATHEROGENIC EFFECTS OF LEPTIN

Zdravniški Vestnik, 2003
Background. Leptin is an adipocyte-derived hormone that was recently discovered. Leptin and leptin resistance play an important role in the pathogenesis of obesity.
Mišo Šabovič, Alenka Mavri
doaj  

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

The role of leptin as a biochemical marker in health and disease

, 2023
Leptin is a hormone primarily produced by adipose tissue (fat cells) and is critical in regulating energy balance and metabolism (Martinez-Sanchez 2020; Abella et al. 2017).
Karimkhani,H.
core  

When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions

Movement Disorders, EarlyView.
Abstract Although Parkinson's disease (PD) is classically defined by its motor features, non‐motor symptoms exert a substantial and often under‐recognized influence on disease trajectory. Among these, weight loss has long been observed in PD and other neurodegenerative disorders, yet the mechanisms remain incompletely understood.
Ellie D. Gabriel, Robert S. Eisinger, Joyce M. Lee, Sarah Hamimi, Hope Kim, Susanna D. Howard, Casey H. Halpern   +6 more
wiley   +1 more source

Leptin endocrinology and energy homeostasis in salmonids

, 2015
In salmonids, the physiological role of leptin is not completely elucidated. Nonetheless, the anorexigenic effect of leptin indicates a role in their energy homeostasis.
Johansson, Marcus
core   +1 more source

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, EarlyView.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source

The Lipid Droplet–Associated Hydrolase Is Associated With Obesity and Adipose Tissue Inflammation in Children

Obesity, EarlyView.
ABSTRACT Objective The lipid droplet–associated hydrolase (LDAH) is a lipid droplet–associated protein with an uncharacterized role in human adipose tissue (AT) and obesity; we aimed to investigate its role in human AT and its relevance for childhood obesity.
Claudia Vales‐Villamarín, Antje Berthold, Martin Lacher, Antje Körner, Kathrin Landgraf   +4 more
wiley   +1 more source

Metabolic syndrome, the leptin gene and kidney disease in non-diabetic black South Africans

, 2008
Includes abstract.Includes bibliographical references (leaves 226-256).Obesity is a worldwide problem and is a factor in the pathogenesis of the metabolic syndrome and kidney disease through the development of obesity-related hypertension and ...
Okpechi, Ikechi Gareth
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