Results 161 to 170 of about 319,296 (404)

The long road to leptin.

Journal of Clinical Investigation, 2016
Leptin is an adipose tissue hormone that functions as an afferent signal in a negative feedback loop that maintains homeostatic control of adipose tissue mass.
J. Friedman
semanticscholar   +1 more source

Undernutrition and stage of gestation influence fetal adipose tissue gene expression [PDF]

, 2015
Funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS), including the Strategic Partnership for Animal Science Excellence (SPASE) and the U.S. National Institutes of Health (HD045784).
Adam, Clare L, Aitken, Raymond P, Horgan, Graham W, Luther, Justin S, Milne, John S, Redmer, Dale A, Reynolds, Lawrence P., Wallace, Jacqueline M   +7 more
core   +1 more source

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial.

Journal of the American Medical Association (JAMA), 1999
CONTEXT The protein hormone leptin is important to the homeostatic regulation of body weight. Treatment with exogenous leptin may affect weight loss. OBJECTIVE To determine the relationship between increasing doses of exogenous leptin administration ...
S. Heymsfield, A. Greenberg, K. Fujioka, R. M. Dixon, R. Kushner, T. Hunt, J. Lubina, Janet Patane, Barbara Self, Pam Hunt, M. Mccamish   +10 more
semanticscholar   +1 more source

Word problems in Elliott monoids [PDF]

arXiv, 2017
Algorithmic issues concerning Elliott local semigroups are seldom considered in the literature, although these combinatorial structures completely classify AF algebras. In general, the addition operation of an Elliott local semigroup is {\it partial}, but for every AF algebra $\mathfrak B$ whose Murray-von Neumann order of projections is a lattice ...
arxiv  

The role of insulin receptor substrate 2 in hypothalamic and beta cell function [PDF]

, 2005
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in beta cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Al-Qassab, H, Ashford, MLJ, Barsh, GS, Batterham, RL, Bedford, DC, Bell, JD, Choudhury, AI, Claret, M, Clements, M, Diakonov, I, Heffron, H, Hisadome, K, MacColl, G, Moosajee, V, Selman, C, Simmgen, M, Smith, MA, Speakman, JR, Withers, DJ, Xu, AW   +19 more
core  

Immunomodulatory role of an Ayurvedic formulation on imbalanced immune-metabolics during inflammatory responses of obesity and pre-diabetic disease [PDF]

arXiv, 2012
Obesity and related type 2 diabetes are associated with a low level chronic inflammatory state with disease status increasing at epidemic proportions worldwide. It is now universally accepted that the underlying immune-inflammatory responses mediated within the adipose tissue in obesity are central to the development of disease. Once initiated, chronic
arxiv  

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Effects of a two‐night hospitalization program as a specific health guidance on obesity and cardiovascular disease risk factors

Journal of General and Family Medicine, EarlyView.
Abstract Background To assess the effects of a two‐night hospitalization program conducted at our hospital as part of a domestic health guidance system. This program is designed for lifestyle modification within a health checkup framework for metabolic syndrome. Methods This is a single‐center, retrospective observational study. We reviewed the medical
Maki Okazaki, Takeshi Katsuki, Hideaki Kurata, Shinichi Tanaka, Hajime Tanaka, Toshihide Kawai   +5 more
wiley   +1 more source

Maternal diet and gestational diabetes mellitus modestly influence children's growth during their first 24 months

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective To evaluate whether diet and gestational diabetes mellitus (GDM) during pregnancy influence children's growth during their first 24 months. Methods Growth data of children (n = 378) of women with overweight/obesity were obtained from clinic records (birth, 3, 6, 12 and 24 months), and variables (standard deviation scores (SDS) or ...
Lotta Saros, Tero Vahlberg, Ella Koivuniemi, Noora Houttu, Kristiina Tertti, Nitin Shivappa, James R. Hébert, Harri Niinikoski, Kirsi Laitinen   +8 more
wiley   +1 more source

Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet.

PLoS ONE, 2014
ObjectiveLeptin resistance is a common hallmark of obesity. Rats on a free-choice high-fat high-sugar (fcHFHS) diet are resistant to peripherally administered leptin. The aim of this study was to investigate feeding responses to central leptin as well as
José K van den Heuvel, Leslie Eggels, Eric Fliers, Andries Kalsbeek, Roger A H Adan, Susanne E la Fleur   +5 more
doaj   +1 more source