Results 271 to 280 of about 151,999 (312)
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Pituitary, 2001
In 1994, Zhang et al. of Rockefeller University in New York reported the first successful complementary DNA (cDNA) cloning of leptin by the positional cloning method. Leptin was identified as the gene of ob/ob mouse in genetic obesity syndromes. It has very strong food intake control, and body weight and energy expenditure.
M, Sone, R Y, Osamura
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In 1994, Zhang et al. of Rockefeller University in New York reported the first successful complementary DNA (cDNA) cloning of leptin by the positional cloning method. Leptin was identified as the gene of ob/ob mouse in genetic obesity syndromes. It has very strong food intake control, and body weight and energy expenditure.
M, Sone, R Y, Osamura
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Reviews of Reproduction, 2000
Placental tissues from humans, rodents and farm animals contain leptin and its receptor. Leptin produced by the human placenta has the same size, charge and immunoreactivity as leptin produced by adipose tissue. However, the expression of human placental leptin appears to be regulated by a placenta-specific upstream enhancer.
Ashworth, CJ +5 more
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Placental tissues from humans, rodents and farm animals contain leptin and its receptor. Leptin produced by the human placenta has the same size, charge and immunoreactivity as leptin produced by adipose tissue. However, the expression of human placental leptin appears to be regulated by a placenta-specific upstream enhancer.
Ashworth, CJ +5 more
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Expression of Placental Leptin and Leptin Receptors in Preeclampsia
International Journal of Gynecological Pathology, 2004This study investigated the expression profile of placental leptin and leptin receptor isoforms in preeclampsia, using placental tissue from normal pregnancies that were matched in gestational age and birth weight as controls. A total of 29 cases of preeclampsia were studied by immunohistochemistry, including 16 severe and 13 mild preeclampsia cases ...
Li, RHW, Poon, SCS, Yu, MY, Wong, YF
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The Journal of Maternal-Fetal & Neonatal Medicine, 2002
Leptin is a 16-kDa polypeptide, encoded in humans by the LEP gene. This protein is probably involved in the regulation of ovarian function, oocyte maturation and embryo development, and in the implantation process. During pregnancy, leptin is produced in the placenta; its values increase in the maternal blood particularly in the second trimester and ...
E, Domali, I E, Messinis
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Leptin is a 16-kDa polypeptide, encoded in humans by the LEP gene. This protein is probably involved in the regulation of ovarian function, oocyte maturation and embryo development, and in the implantation process. During pregnancy, leptin is produced in the placenta; its values increase in the maternal blood particularly in the second trimester and ...
E, Domali, I E, Messinis
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Cellular Signalling, 2002
The identification of leptin as the product of the obesity (ob) gene has been followed by extensive research identifying a wide spectrum of physiological effects elicited by this adipose-derived hormone. These effects are mediated via a family of cytokine-like receptor isoforms distributed in both the central nervous system and periphery.
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The identification of leptin as the product of the obesity (ob) gene has been followed by extensive research identifying a wide spectrum of physiological effects elicited by this adipose-derived hormone. These effects are mediated via a family of cytokine-like receptor isoforms distributed in both the central nervous system and periphery.
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hmbci, 2011
Abstract Leptin, which comes from the Greek root leptos meaning thin, has been the focus of intense investigation since its discovery in 1994. This hormone belongs to the cytokine family and is produced by adipocytes and circulates in proportion to fat mass, thus serving as ...
Julie A, Chowen, Jesús, Argente
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Abstract Leptin, which comes from the Greek root leptos meaning thin, has been the focus of intense investigation since its discovery in 1994. This hormone belongs to the cytokine family and is produced by adipocytes and circulates in proportion to fat mass, thus serving as ...
Julie A, Chowen, Jesús, Argente
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Microscopy Research and Technique, 2001
AbstractThe recent discovery of gastric leptin has initiated several investigations on the possible role of leptin in digestive physiology. The following clues are currently suggested: leptin might control meal size in cooperation with Cholecystokinin, help cytoprotection of the gastric mucosa, play a role in gut inflammatory processes, regulate ...
M J, Lewin, A, Bado
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AbstractThe recent discovery of gastric leptin has initiated several investigations on the possible role of leptin in digestive physiology. The following clues are currently suggested: leptin might control meal size in cooperation with Cholecystokinin, help cytoprotection of the gastric mucosa, play a role in gut inflammatory processes, regulate ...
M J, Lewin, A, Bado
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Leptin-Signaling Pathways and Leptin Resistance
2009Leptin acts as an anorexigenic hormone in the brain, where the long form of the leptin receptor (LRb) is widely expressed in hypothalamic and extra-hypothalamic sites that are known to participate in diverse feeding circuits. The important role of leptin in energy homeostasis is demonstrated by the profound hyperphagia and morbid obesity in humans and ...
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Journal of Cellular Physiology, 2005
AbstractThe prevalence of obesity has markedly increased over the past two decades, especially in the industrialized countries. While the impact of excess body weight on the development of cardiac disease and diabetes has been well documented, the link between obesity and carcinogenesis is just being recognized.
Cecilia, Garofalo, Eva, Surmacz
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AbstractThe prevalence of obesity has markedly increased over the past two decades, especially in the industrialized countries. While the impact of excess body weight on the development of cardiac disease and diabetes has been well documented, the link between obesity and carcinogenesis is just being recognized.
Cecilia, Garofalo, Eva, Surmacz
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Nutrition Reviews, 2002
it is certainly a major player. Priorexperience with hormonal signals such as insulin sug-gested that leptin would have pleiotropic actions invarious end organs and that its signals would be inte-grated into a complicated system of checks and balancesinvolving other hormones and neural pathways. Thesepredictions have turned out to be true,
Prentice, Andrew M. +3 more
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it is certainly a major player. Priorexperience with hormonal signals such as insulin sug-gested that leptin would have pleiotropic actions invarious end organs and that its signals would be inte-grated into a complicated system of checks and balancesinvolving other hormones and neural pathways. Thesepredictions have turned out to be true,
Prentice, Andrew M. +3 more
openaire +3 more sources