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Adipokines and mortality in burns and traumatic brain injury. [PDF]
Trauma Surg Acute Care OpenMa Y +3 more
europepmc +1 more source
Genetic variability in the leptin-melanocortin pathway and its role in weight loss. [PDF]
Mol MetabSantos-Pereira M +4 more
europepmc +1 more source
Leptin signaling and leptin resistance [PDF]
Frontiers of Medicine, 2013 Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity. Leptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neurons in the brain ...
Yingjiang Zhou +2 more
exaly +3 more sources
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The Lancet, 1998
Leptin (from the Greek leptos=thin) was identified only 3 years ago. It has attracted huge attention both scientifically, with more than 600 publications, and in the media, where this protein has been portrayed as the way to a cure for obesity. Indeed, leptin was first described as an adipocyte-derived signalling factor, which, after interaction with ...
J, Auwerx, B, Staels
openaire +4 more sources
Leptin (from the Greek leptos=thin) was identified only 3 years ago. It has attracted huge attention both scientifically, with more than 600 publications, and in the media, where this protein has been portrayed as the way to a cure for obesity. Indeed, leptin was first described as an adipocyte-derived signalling factor, which, after interaction with ...
J, Auwerx, B, Staels
openaire +4 more sources
The Netherlands Journal of Medicine, 1996
A highly conserved protein called 'leptin' was recently discovered to play a role in regulation of the energy balance in humans and rodents. This 167-amino-acid-containing protein is only produced and secreted by mature adipocytes. Absence of the protein in mutant ob/ob mice and resistance to its effects in db/db mice lead to extreme obesity and type ...
A E, Meinders, A C, Toornvliet, H, Pijl
openaire +2 more sources
A highly conserved protein called 'leptin' was recently discovered to play a role in regulation of the energy balance in humans and rodents. This 167-amino-acid-containing protein is only produced and secreted by mature adipocytes. Absence of the protein in mutant ob/ob mice and resistance to its effects in db/db mice lead to extreme obesity and type ...
A E, Meinders, A C, Toornvliet, H, Pijl
openaire +2 more sources
Dermatitis®, 2011
Leptin belongs to the helical cytokine family and has structural similarity to interleukin (IL)-6, IL-12, IL-15, prolactin, and growth hormone. It is mainly secreted by adipocytes but (at lower levels) also by stomach, skeletal muscle, and placenta.
Balato N +4 more
openaire +6 more sources
Leptin belongs to the helical cytokine family and has structural similarity to interleukin (IL)-6, IL-12, IL-15, prolactin, and growth hormone. It is mainly secreted by adipocytes but (at lower levels) also by stomach, skeletal muscle, and placenta.
Balato N +4 more
openaire +6 more sources
Mechanisms of Leptin Action and Leptin Resistance
Annual Review of Physiology, 2008The adipose tissue–derived hormone leptin acts via its receptor (LRb) in the brain to regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a number of other pathways is required for the totality of leptin action. The failure of elevated leptin levels to suppress feeding and mediate weight loss in common forms of obesity ...
Martin G, Myers +2 more
openaire +2 more sources
Nutrition Reviews, 2002
Leptin, a hormone secreted from adipose tissue, plays an important role in reproductive physiology. It has been shown to stimulate the reproductive system by rescuing the sterility of leptin-deficient mice and advancing the onset of puberty in normal mice.
Farid F, Chehab +4 more
openaire +2 more sources
Leptin, a hormone secreted from adipose tissue, plays an important role in reproductive physiology. It has been shown to stimulate the reproductive system by rescuing the sterility of leptin-deficient mice and advancing the onset of puberty in normal mice.
Farid F, Chehab +4 more
openaire +2 more sources