Results 351 to 360 of about 324,634 (386)
Some of the next articles are maybe not open access.
Trends in Endocrinology & Metabolism, 2001
In mammals, the function of the reproductive system is dependent on the availability of energy in the environment. It is well established that acute modifications of energy balance modulate the hypothalamic-pituitary-gonadal axis. In several species, fasting and caloric restriction have been shown to cause the suppression of pulsatile luteinizing ...
Caprio M. +4 more
openaire +2 more sources
In mammals, the function of the reproductive system is dependent on the availability of energy in the environment. It is well established that acute modifications of energy balance modulate the hypothalamic-pituitary-gonadal axis. In several species, fasting and caloric restriction have been shown to cause the suppression of pulsatile luteinizing ...
Caprio M. +4 more
openaire +2 more sources
Mechanisms of Leptin Action and Leptin Resistance
Annual Review of Physiology, 2008The adipose tissue–derived hormone leptin acts via its receptor (LRb) in the brain to regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a number of other pathways is required for the totality of leptin action. The failure of elevated leptin levels to suppress feeding and mediate weight loss in common forms of obesity ...
Martin G. Myers +2 more
openaire +3 more sources
The Journal of Maternal-Fetal & Neonatal Medicine, 2002
Leptin is a 16-kDa polypeptide, encoded in humans by the LEP gene. This protein is probably involved in the regulation of ovarian function, oocyte maturation and embryo development, and in the implantation process. During pregnancy, leptin is produced in the placenta; its values increase in the maternal blood particularly in the second trimester and ...
Ekaterini Domali, Ioannis E. Messinis
openaire +3 more sources
Leptin is a 16-kDa polypeptide, encoded in humans by the LEP gene. This protein is probably involved in the regulation of ovarian function, oocyte maturation and embryo development, and in the implantation process. During pregnancy, leptin is produced in the placenta; its values increase in the maternal blood particularly in the second trimester and ...
Ekaterini Domali, Ioannis E. Messinis
openaire +3 more sources
Leptin in autoimmune diseases [PDF]
Metabolism, 2007 The past twenty years of research on leptin has provided crucial information on the link between metabolic state and immune system function. Adipocytes influence not only the endocrine system but also the immune response, through several cytokine-like mediators known as adipokines, which include leptin.
Giuseppe Matarese +4 more
openaire +8 more sources
Nutrition Reviews, 2002
Leptin, a hormone secreted from adipose tissue, plays an important role in reproductive physiology. It has been shown to stimulate the reproductive system by rescuing the sterility of leptin-deficient mice and advancing the onset of puberty in normal mice.
Jun Qiu +4 more
openaire +3 more sources
Leptin, a hormone secreted from adipose tissue, plays an important role in reproductive physiology. It has been shown to stimulate the reproductive system by rescuing the sterility of leptin-deficient mice and advancing the onset of puberty in normal mice.
Jun Qiu +4 more
openaire +3 more sources
Reviews of Reproduction, 1999
In the few years since leptin was identified as a satiety factor in rodents, it has been implicated in the regulation of various physiological processes. Leptin has been shown to promote sexual maturation in rodent species and a role in reproduction has been investigated at various sites within the hypothalamo-pituitary-gonadal axis.
Iain J. Clarke, Belinda A. Henry
openaire +3 more sources
In the few years since leptin was identified as a satiety factor in rodents, it has been implicated in the regulation of various physiological processes. Leptin has been shown to promote sexual maturation in rodent species and a role in reproduction has been investigated at various sites within the hypothalamo-pituitary-gonadal axis.
Iain J. Clarke, Belinda A. Henry
openaire +3 more sources
Leptin, Obesity, and Leptin Resistance
2014The cloning of leptin in 1994 was an important milestone in obesity research. In those days obesity was rather stigmatized as a condition caused by lack of character and self-control. With leptin and its receptor being the first single genes that could cause morbid obesity in man and mice, it is now appreciated that obesity is caused by a dysregulation
Steven B. Heymsfield, Heike Münzberg
openaire +2 more sources
Leptin Function and Regulation.
Comprehensive Physiology, 2017We summarize the biological impact of leptin signaling as well as the molecular and cellular characteristics of leptin action. Our focus is principally in the central nervous system and we describe the properties of the neuronal networks that are ...
Yiying Zhang, S. Chua
semanticscholar +1 more source
hmbci, 2011
Abstract Leptin, which comes from the Greek root leptos meaning thin, has been the focus of intense investigation since its discovery in 1994. This hormone belongs to the cytokine family and is produced by adipocytes and circulates in proportion to fat mass, thus serving as a satiety signal and informing central metabolic control centers
Jesús Argente, Julie A. Chowen
openaire +3 more sources
Abstract Leptin, which comes from the Greek root leptos meaning thin, has been the focus of intense investigation since its discovery in 1994. This hormone belongs to the cytokine family and is produced by adipocytes and circulates in proportion to fat mass, thus serving as a satiety signal and informing central metabolic control centers
Jesús Argente, Julie A. Chowen
openaire +3 more sources
The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes
Trends in Pharmacological Sciences, 1999Support for our work comes mostly from the Centre National de la Recherche Scientifique, the Institut National de la Sante et de la Recherche Medicale, the University of Paris VII, the Ministry for Research and Technology. We are also grateful for help from the Ligue Nationale contre le Cancer, the Fondation pour la Recherche Medicale Francaise and ...
Arthur Donny Strosberg, Tarik Issad
openaire +3 more sources