Structural insights into the mechanism of leptin receptor activation [PDF]
Nature Communications, 2023 Leptin is an adipocyte-derived protein hormone that promotes satiety and energy homeostasis by activating the leptin receptor (LepR)–STAT3 signaling axis in a subset of hypothalamic neurons.
Robert A. Saxton +7 more
doaj +3 more sources
On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin [PDF]
Frontiers in Endocrinology, 2017 Over a decade passed between Friedman’s discovery of the mammalian leptin gene (1) and its cloning in fish (2) and amphibians (3). Since 2005, the concept of gene synteny conservation (vs.
R. Londraville +4 more
semanticscholar +3 more sources
C-Reactive Protein (CRP) and Leptin Receptor in Obesity: Binding of Monomeric CRP to Leptin Receptor
Frontiers in Immunology, 2018 While leptin deficiency or dysfunction leads to morbid obesity, obese subjects are characterized paradoxically by hyperleptinemia indicating lack of response to leptin.
Manu Sudhakar +4 more
doaj +2 more sources
Discovery of the elusive leptin in birds: identification of several 'missing links' in the evolution of leptin and its receptor. [PDF]
PLoS ONE, 2014 Leptin is a pleiotropic protein best known for regulation of appetite and fat storage in mammals. While many leptin orthologs have been identified among vertebrates, an authentic leptin in birds has remained elusive and controversial.
Jeremy W Prokop +10 more
doaj +2 more sources
Leptin induces IL-6 expression through OBRl receptor signaling pathway in human synovial fibroblasts. [PDF]
PLoS ONE, 2013 BACKGROUND: Leptin, an adipocyte-secreted hormone that centrally regulates weight control, may exert proinflammatory effects in the joint, depending on the immune response.
Wei-Hung Yang +6 more
doaj +2 more sources
Identification and expression cloning of a leptin receptor, OB-R
Cell, 1995 Louis A. Tartaglia +18 more
openalex +2 more sources
New pharmacological perspectives for the leptin receptor in the treatment of obesity
Frontiers in Endocrinology, 2014 After its discovery in 1994, leptin became the great hope as an anti-obesity treatment based on its ability to reduce food intake and increase energy expenditure.
Clara eRoujeau +2 more
doaj +2 more sources
Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken [PDF]
Archives of Razi Institute, 2021 The present study aimed to assess the probable impact of the central histaminergic and melanocortin systems on leptin-induced hypophagia in neonatal layer chickens.
M Shalikar +3 more
doaj +1 more source
European Journal of Medical Research, 2010 Leptin or obesity receptor (Ob-R) is a member of class I cytokine receptor family. Ob-R, expressed in six isoforms, is the product of alternative RNA splicing of db gene. According to its structural differences, the receptor's isoforms are divided into three classes: long, short, and secretory isoforms.
Anna Stelmaszczyk-Emmel +5 more
openaire +3 more sources