Results 1 to 10 of about 73,646 (146)
Structural insights into the mechanism of leptin receptor activation [PDF]
Nature Communications, 2023 Leptin is an adipocyte-derived protein hormone that promotes satiety and energy homeostasis by activating the leptin receptor (LepR)–STAT3 signaling axis in a subset of hypothalamic neurons.
Robert A. Saxton +7 more
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Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken [PDF]
Archives of Razi Institute, 2021 The present study aimed to assess the probable impact of the central histaminergic and melanocortin systems on leptin-induced hypophagia in neonatal layer chickens.
M Shalikar +3 more
doaj +1 more source
Human Pathology Reports, 2022 Context: Breast cancer is the most common cancer and the most common cause of death from cancer among women. Leptin is thought to play role in cell proliferation.
Irem Atalay Karacay +5 more
doaj +1 more source
Leptin-Activity Modulators and Their Potential Pharmaceutical Applications
Biomolecules, 2021 Leptin, a multifunctional hormone primarily, but not exclusively, secreted in adipose tissue, is implicated in a wide range of biological functions that control different processes, such as the regulation of body weight and energy expenditure ...
Marianna Greco +6 more
doaj +1 more source
European Journal of Medical Research, 2010 Leptin or obesity receptor (Ob-R) is a member of class I cytokine receptor family. Ob-R, expressed in six isoforms, is the product of alternative RNA splicing of db gene. According to its structural differences, the receptor's isoforms are divided into three classes: long, short, and secretory isoforms.
Gorska, E +5 more
openaire +2 more sources
Leptin and leptin receptor expression in asthma [PDF]
Journal of Allergy and Clinical Immunology, 2009 The adipokine leptin is a potential new mediator for bronchial epithelial homeostasis. Asthma is a chronic inflammatory disease characterized by airway remodeling that might affect disease chronicity and severity. TGF-beta is a tissue growth factor the dysregulation of which is associated with airway remodeling.We sought to determine whether a ...
Andreina, Bruno +9 more
+7 more sources
Leptin and leptin receptor expressions in prostate tumors may predict disease aggressiveness? [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE: The aim of this study was to evaluate the expression of leptin and its receptor in histological sections of prostate tumors, and their association with prognostic factors.
Clarice F. Osório +4 more
doaj +1 more source
Folia Histochemica et Cytobiologica, 2008 Leptin and its receptor may be engaged in pathogenesis of breast cancer among various human tumors. In vitro investigations showed leptin-mediated escalation of estrogen synthesis and boosted activity of estrogen receptor ERalpha.
Stanislaw Sulkowski +4 more
doaj +3 more sources
Leptin inhibits neutrophil apoptosis in children via ERK/NF-κB-dependent pathways. [PDF]
PLoS ONE, 2013 Previous studies have shown that delayed neutrophil apoptosis is associated with chronic airway diseases. Leptin is an adipocyte-derived hormone that acts as a regulator of energy homeostasis and food intake.
Zhizhi Sun +3 more
doaj +1 more source
Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric Carcinomas. [PDF]
PLoS ONE, 2015 We investigated the clinicopathological implications of leptin-signaling proteins and Epstein-Barr virus (EBV)-infection status in gastric carcinomas. Immunohistochemistry for leptin signalling-related proteins (leptin, leptin-receptor, pSTAT3, ERK, pAkt,
Euno Choi +7 more
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