Results 171 to 180 of about 73,797 (197)
Some of the next articles are maybe not open access.
Journal of Chemical Neuroanatomy, 2014
Leptin is mainly produced in the white adipose tissue before being secreted into the blood and transported across the blood-brain barrier. Leptin binds to a specific receptor (LepR) that has numerous subtypes (LepRa, LepRb, LepRc, LepRd, LepRe, and LepRf).
Nobuhiro, Wada +5 more
openaire +2 more sources
Leptin is mainly produced in the white adipose tissue before being secreted into the blood and transported across the blood-brain barrier. Leptin binds to a specific receptor (LepR) that has numerous subtypes (LepRa, LepRb, LepRc, LepRd, LepRe, and LepRf).
Nobuhiro, Wada +5 more
openaire +2 more sources
Leukemia & Lymphoma, 2000
The receptor for leptin, the gene product of the obese gene, is expressed in hematopoietic stem cells. Leptin stimulates normal myeloid and erythroid development, and is secreted from bone marrow adipocytes, which occupy most of the marrow cavity in humans.
M, Hino +5 more
openaire +2 more sources
The receptor for leptin, the gene product of the obese gene, is expressed in hematopoietic stem cells. Leptin stimulates normal myeloid and erythroid development, and is secreted from bone marrow adipocytes, which occupy most of the marrow cavity in humans.
M, Hino +5 more
openaire +2 more sources
2011
The hormone leptin, secreted predominantly from adipose tissue, plays a crucial role in the regulation of numerous neuroendocrine functions, from energy homeostasis to reproduction. Genetic deficiency as a consequence of leptin or leptin receptor mutations, although rare in humans, leads to early onset of chronic hyperphagia and massive obesity.
Elizabeth C, Cottrell, Julian G, Mercer
openaire +2 more sources
The hormone leptin, secreted predominantly from adipose tissue, plays a crucial role in the regulation of numerous neuroendocrine functions, from energy homeostasis to reproduction. Genetic deficiency as a consequence of leptin or leptin receptor mutations, although rare in humans, leads to early onset of chronic hyperphagia and massive obesity.
Elizabeth C, Cottrell, Julian G, Mercer
openaire +2 more sources
Expression of Placental Leptin and Leptin Receptors in Preeclampsia
International Journal of Gynecological Pathology, 2004This study investigated the expression profile of placental leptin and leptin receptor isoforms in preeclampsia, using placental tissue from normal pregnancies that were matched in gestational age and birth weight as controls. A total of 29 cases of preeclampsia were studied by immunohistochemistry, including 16 severe and 13 mild preeclampsia cases ...
Li, RHW, Poon, SCS, Yu, MY, Wong, YF
openaire +4 more sources
Leptin and leptin receptor-related monogenic obesity
Biochimie, 2012The studies based on candidate genes and encoded proteins known to cause severe obesity in rodents, have shown that these genes also contribute to human early-onset obesity especially for those involved in the leptin pathway: the leptin (LEP) and leptin receptor (LEPR) genes.
Beatrice, Dubern, Karine, Clement
openaire +2 more sources
Role of leptin and leptin receptors in hematological malignancies
Leukemia & Lymphoma, 2015Leptin is an adipose-derived cytokine that has an important role in bodyweight homeostasis and energy balance. There are a number of studies which have suggested that leptin and its receptors dysregulation play a critical role in the development of malignancies including hematological malignancies, mainly via activation of the JAK/STAT pathway which ...
Shahab, Uddin, Ramzi M, Mohammad
openaire +2 more sources
Leptin and Leptin Receptor in Anterior Pituitary Function
Pituitary, 2001Leptin is a 16 kDa protein that exerts important effects on the regulation of food intake and energy expenditure by interacting with the leptin receptor in the brain and in many other tissues. Although leptin is produced mainly by white adipose tissue, several laboratories have shown low levels of leptin production by a growing number of tissues ...
R V, Lloyd +8 more
openaire +2 more sources
Leptin, leptin soluble receptor and coronary atherosclerosis
Experimental and Clinical Endocrinology & Diabetes, 2007AbstractBackground The adipose tissue‐related hormone leptin plays an important role in the regulation of body weight. The associations of leptin and leptin soluble receptor (sOb‐R) with coronary artery disease (CAD) are not clear.Design We measured leptin and sOb‐R in 543 consecutive patients (379 men, 164 women) referred for coronary angiography ...
G, Hoefle +9 more
openaire +2 more sources
Leptin, Leptin Receptors, and the Control of Body Weight
Nutrition Reviews, 2009The assimilation, storage, and disposition of nutrient energy constitute a complex homeostatic system central to the survival of both prokaryotic and eukaryotic organisms. In vertebrates, and especially among land dwelling mammalian species, the ability to store large quantities of energy-dense fuel in the form of adipose tissue triglyceride permits ...
openaire +3 more sources
Localization of leptin and leptin receptor in the bovine adenohypophysis
Domestic Animal Endocrinology, 2008The present study was carried out to detail the cellular localization of leptin (Lep) and the leptin receptor (LepR) in the bovine adenohypophysis. Lep immunoreactivity (Lep-ir) was found in about 30% of adenohypophysial cells in the gland. Immunochemistry of Lep and specific hormones using serial sections revealed that Lep-ir was present in 60.4% of ...
Hideki, Ogasawara +8 more
openaire +2 more sources