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Localization of Leptin Binding Domain in the Leptin Receptor
Molecular Pharmacology, 1998The leptin receptor is a member of the class I cytokine receptor family and is involved in the control of appetite and body weight. The predicted amino acid sequence of the extracellular region of the cloned leptin receptor differs from that of many other cytokine receptors in that it contains two homologous segments representing potential ligand ...
T M, Fong +8 more
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Immunoassays for Leptin and Leptin Receptors
2006Availability of methods for accurate and reproducible quantification of lepth in various biological fluids in humans and in animals has greatly facilitated research leading to the understanding of its role in various physiological and pathophysiological conditions. Immunoassay techniques provide a simple and robust tool for measurement of biomolecules.
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The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes
Trends in Pharmacological Sciences, 1999Support for our work comes mostly from the Centre National de la Recherche Scientifique, the Institut National de la Sante et de la Recherche Medicale, the University of Paris VII, the Ministry for Research and Technology. We are also grateful for help from the Ligue Nationale contre le Cancer, the Fondation pour la Recherche Medicale Francaise and ...
A D, Strosberg, T, Issad
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Serum leptin levels, skin leptin and leptin receptor expression in psoriasis
British Journal of Dermatology, 2008Recent studies support the relation of psoriasis with obesity and cardiovascular disease. Leptin, a peptide hormone secreted predominantly from adipose tissue, is involved in the regulation of energy intake and expenditure. Recently, it has been shown to have several immunological effects including induction of proinflammatory cytokine production.To ...
A A, Cerman +5 more
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Nihon rinsho. Japanese journal of clinical medicine, 1998
Leptin is a fat cell-derived satiety factor that regulates food intake and energy expenditure. Its effects are mediated by interactions with the leptin receptor (Ob-R) that is alternatively spliced to encode at least five isoforms(a-e), which are distributed in a wide range of tissues including the hypothalamus.
K, Takaya +5 more
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Leptin is a fat cell-derived satiety factor that regulates food intake and energy expenditure. Its effects are mediated by interactions with the leptin receptor (Ob-R) that is alternatively spliced to encode at least five isoforms(a-e), which are distributed in a wide range of tissues including the hypothalamus.
K, Takaya +5 more
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Nihon rinsho. Japanese journal of clinical medicine, 2002
Yoshihiro, Ogawa, Kazuwa, Nakao
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Yoshihiro, Ogawa, Kazuwa, Nakao
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Antagonizing the Leptin Receptor in Obesity
New England Journal of Medicine, 2023openaire +2 more sources