Results 61 to 70 of about 2,914 (160)

Digital Psychological Wellbeing Interventions for Family Carers of Children and Adults With Intellectual and Developmental Disabilities: A Systematic Review

Journal of Applied Research in Intellectual Disabilities, Volume 38, Issue 4, July 2025.
ABSTRACT Background This review explored (1) what digital psychological wellbeing interventions for family carers of people with intellectual and developmental disabilities were reported in the literature, (2) evidence about their effectiveness, (3) factors affecting their implementation and (4) experiences of family carers who attend them.
Magda M. Apanasionok, Andreas Paris, Joanna Griffin, Richard P. Hastings, Ellie Finch, Debbie Austin, Samantha Flynn   +6 more
wiley   +1 more source

Varieties of Pathological Self-Mutilation

Behavioural Neurology, 1990
Pathological self-mutilation appears as a non-specific symptom as well as a specific syndrome. Since psychotic persons may commit horrifying acts, such as enucleation of an eye or amputation of a body part, identification of high risk patients is crucial.
Armando R. Favazza, Richard J. Rosenthal
doaj   +1 more source

Which neurodevelopmental disorders get researched and why?

PLoS ONE, 2010
AimThere are substantial differences in the amount of research concerned with different disorders. This paper considers why.MethodsBibliographic searches were conducted to identify publications (1985-2009) concerned with 35 neurodevelopmental disorders ...
Dorothy V M Bishop
doaj   +1 more source

Prospective Characterisation of Age‐Related Changes in Self‐Injurious Behaviour in a Sample of Children With Global Developmental Delay Aged 2–12 Years

Journal of Intellectual Disability Research, Volume 69, Issue 6, Page 465-479, June 2025.
ABSTRACT Background Self‐injurious behaviour (SIB) is a common problem among individuals with intellectual and developmental disabilities (IDDs) with important impacts on quality of life. Although some evidence suggests that SIB may increase with age, perhaps in a curvilinear pattern, this is primarily based on cross‐sectional studies.
Breanne J. Byiers, Jaclyn Gunderson, Andrea Huebner, Frank J. Symons   +3 more
wiley   +1 more source

Lesch-Nyhan syndrome: A case report

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2008
Lesch-Nyhan syndrome, a rare inborn error of metabolism, is characterized by mental retardation and self-destructive behavior resulting in self-mutilation through biting and scratching.
Kale A, Shah K, Hallikerimath S
doaj  

Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship

Annals of Neurology, Volume 97, Issue 5, Page 809-825, May 2025.
Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino, Audrey G. O'Neill, Justin M. Kollman, Hyder A. Jinnah, Michael Zech   +4 more
wiley   +1 more source

Bipolar affective disorder: A review of novel forms of therapy

Current Issues in Pharmacy and Medical Sciences, 2015
Normothymic, antidepressant and antipsychotic pharmaceutics are, in accordance with international guidelines, employed both in the therapy and the prevention of bipolar disorder (BD).
Dziwota Ewelina, Drapala Barbara, Gaj Magdalena, Skoczen Nikodem, Olajossy Marcin   +4 more
doaj   +1 more source

Diagnosis of Inherited Metabolic Disease in Older Patients: A Systematic Literature Review

Journal of Inherited Metabolic Disease, Volume 48, Issue 3, May 2025.
ABSTRACT Inherited metabolic diseases (IMDs) are genetic disorders that disrupt biochemical processes in the human body, due to pathogenic variants in genes encoding enzymes or transporters. While IMDs are mostly diagnosed in infancy or childhood, there is an increasing number of diagnoses in adult patients.
Maria‐Rita Moio, Julia Cordeiro Milke, Yannick Moutapam‐Ngamby‐Adriaansen, Arthur Minas Alberti, Marie Gernay, Eduardo Augusto Schutz, Ida Vanessa Doederlein Schwartz, François Maillot   +7 more
wiley   +1 more source

Disability, Relational Equality, and the Expressivist Objection

Hastings Center Report, Volume 55, Issue 2, Page 15-25, March‐April 2025.
Abstract Proponents of the expressivist objection argue that the use and provision of testing to select against disability in offspring express negative judgments about existing persons with disabilities. But does the expression of such judgments also wrong those persons?
Erik Magnusson
wiley   +1 more source

β-Amyloid precursor protein (APP) and the human diseases

AIMS Neuroscience, 2019
Several pathophysiological functions of the human β-amyloid precursor protein (APP) have been recently proposed in different human diseases such as neurodevelopmental and neurodegenerative disorders including rare diseases such as autism, fragile X ...
Khue Vu Nguyen
doaj   +1 more source