Results 81 to 90 of about 3,826,952 (368)

GSplit LBI: Taming the Procedural Bias in Neuroimaging for Disease Prediction

, 2017
In voxel-based neuroimage analysis, lesion features have been the main focus in disease prediction due to their interpretability with respect to the related diseases.
H Zou, J Ashburner, J Ashburner, Jailin Peng, L Grosenick, LI Rudin, LR Dice, R Tibshirani, RJ Tibshirani, Stanley Osher, Z Dai   +10 more
core   +2 more sources

Effectiveness of endoscopic papillectomy with stent placement in pancreatic and bile ducts for treating duodenal papillary adenoma: a retrospective study

BMC Gastroenterology
Background Duodenal papillary adenoma, a potentially malignant benign tumor is primarily treated with endoscopic papillectomy. Despite its efficacy, endoscopic papillectomy has a high complication rate. This study investigates whether pancreatic duct and
Jiani Jiang, Fujing Lv, Chuyan Chen, Wei Jiang   +3 more
doaj   +1 more source

A Circulating miRNA-Based Scoring System Established by WGCNA to Predict Colon Cancer

Analytical Cellular Pathology, 2019
Introduction. Circulation microRNAs (miRNAs) perform as potential diagnostic biomarkers of many kinds of cancers. This study is aimed at identifying circulation miRNAs as diagnostic biomarkers in colon cancer. Methods.
Da Qin, Rui Wei, Si Liu, Shengtao Zhu, Shutian Zhang, Li Min   +5 more
doaj   +1 more source

Retinal Lesion Detection With Deep Learning Using Image Patches

Investigative Ophthalmology and Visual Science, 2018
Purpose To develop an automated method of localizing and discerning multiple types of findings in retinal images using a limited set of training data without hard-coded feature extraction as a step toward generalizing these methods to rare disease ...
Carson K. Lam, Caroline Yu, Laura C. Huang, D. Rubin   +3 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

GP-Unet: Lesion Detection from Weak Labels with a 3D Regression Network

, 2017
We propose a novel convolutional neural network for lesion detection from weak labels. Only a single, global label per image - the lesion count - is needed for training.
A Hofman, Gerda Bortsova, J Ramirez, Lucia Ballerini, RS Desikan, S Hwang, S Klein, SH Park, Ö Çiçek   +8 more
core   +1 more source

Disentangling interoception: insights from focal strokes affecting the perception of external and internal milieus

Frontiers in Psychology, 2015
Interoception is the moment-to-moment sensing of the physiological condition of the body. The multimodal sources of interoception can be classified into two different streams of afferents: an internal pathway of signals arising from core structures (i.e.,
Agustin eIbanez
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Pain relief following spinal lesion treatment with stereotactic radiosurgery: Clinical experience in 65 cases

Journal of Medical Sciences, 2015
Background: This study determines the pain-reducing effect of CyberKnife radiosurgery in the treatment of spinal lesions. Materials and Methods: We evaluated the clinical outcomes of patients treated with CyberKnife radiosurgery for spinal lesions in 65 ...
Shih-Wei Hsu, Hsing-Lung Chao, Kuen-Tze Lin, Yu-Ching Chou, Cheng-Hsiang Lo, Shih-Yu Lee, Wen-Yen Huang, Chun-Shu Lin, Chien-Min Lin, Chao-Yueh Fan, Da-Tong Ju   +10 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source