Results 61 to 70 of about 1,864,013 (297)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1α

Signal Transduction and Targeted Therapy, 2021
Zhou Yang, Yingjun Quan, Yusheng Chen, Yijun Huang, Renhong Huang, Weiping Yu, Dejun Wu, Min Ye, Zhijun Min, Bo Yu   +9 more
doaj   +1 more source

Precision‐Optimised Post‐Stroke Prognoses

Annals of Clinical and Translational Neurology
Background Current medicine cannot confidently predict who will recover from post‐stroke impairments. Researchers have sought to bridge this gap by treating the post‐stroke prognostic problem as a machine learning problem, reporting prediction error ...
Thomas M. H. Hope, Howard Bowman, Rachel M. Bruce, Alex P. Leff, Cathy J. Price   +4 more
doaj   +1 more source

The creation of breast lesion models for mammographic virtual clinical trials: a topical review [PDF]

, 2023
Astrid Van Camp, Katrien Houbrechts, Lesley Cockmartin, Henry C. Woodruff, Philippe Lambin, Nicholas Marshall, Hilde Bosmans   +6 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Feline platynosomiasis: analysis of the association of infection levels with pathological and biochemical findings

Revista Brasileira de Parasitologia Veterinária
Platynosomiasis is a common feline hepatic disease caused by Platynosomum fastosum (Trematoda - Dicrocoelidae), which is also known as ‘lizard poisoning’.
Dirceu Guilherme de Souza Ramos, Amanda Raiza Gonçalves Lima Oliveira Santos, Leodil da Costa Freitas, Ísis Assis Braga, Erica Pereira da Silva, Luciana Maria Curtio Soares, Nádia Aline Bobbi Antoniassi, Fernando Henrique Furlan, Richard de Campos Pacheco   +8 more
doaj   +1 more source

Pathologies of Oligacanthorhynchus pardalis (Acanthocephala, Oligacanthorhynchidae) in Leopardus tigrinus (Carnivora, Felidae) in Southern Brazil Patologias de Oligacanthorhynchus pardalis (Acanthocephala, Oligacanthorhynchidae) em Leopardus tigrinus (Carnivora, Felidae) no sul do Brasil

Revista Brasileira de Parasitologia Veterinária, 2012
In Brazil, Oligacanthorhynchus pardalis (Westrumb, 1821) Schmidt, 1972 has been observed in five species of wild felines. In the present study, five roadkilled oncillas (Leopardus tigrinus Schreber, 1775) were collected in the State of Rio Grande do Sul,
Moisés Gallas, Eliane Fraga da Silvera
doaj   +1 more source