Results 21 to 30 of about 1,200,143 (253)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Cyclurban - A lessons learned report [PDF]

, 2020
The lessons learned report summarizes the findings of the project „Cycling as an element of urban climate mitigation policy (Cyclurban)”. The project advance cycling as a measure for sustainable urban mobility and climate mitigation on a local level.
Vlastos, Thanos, Arikas, Damian, Sonne Krogmann, Clara, Assimakopoulou, Vasiliki, Hardinghaus, Michael, Brückmann, Robert, Lipu, Jolanda, Karolemeas, Christos   +7 more
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Kreativität als Treiber beim Erlernen computergestützter Arbeitsmethoden in den Ingenieurwissenschaften

Lessons Learned, 2023
Die geringe Effektivität bloßen Frontalunterrichts bei der Vermittlung von Software für computergestütztes Arbeiten ist eine Herausforderung für Lernende und Lehrende. In diesem Artikel wird vorgestellt, wie durch den bewusst geforderten kreativen Umgang
Anselm Naake
doaj  

Field Report from Collaborative Research Center 1625: Heterogeneous Research Data Management Using Ontology Representations

Advanced Engineering Materials, EarlyView.
A unified research data management framework for heterogeneous materials data is presented. The system integrates multimodal datasets using ontologies and knowledge graphs, enabling interoperability and FAIR (findable, accessible, interoperable, reusable) data principles. By linking data across scales and workflows, it supports reproducible, Artifitial
Doaa Mohamed, Samuel García Vázquez, Behnam Mardani, Victor Dudarev, Alfred Ludwig, Maribel Acosta, Markus Stricker   +6 more
wiley   +1 more source

Die SLUB Dresden als hybrides Lernzentrum im Projekt virTUos

Lessons Learned, 2023
Als Universitätsbibliothek der TU Dresden unterstützt die Sächsische Landesbibliothek – Staats- und Universitätsbibliothek Dresden (SLUB) deren Entwicklung eines hybriden Lehrangebotes, das analoge und digitale Settings mit den Prinzipien von Offenheit ...
Julia Meyer
doaj  

Is an Apple an Orange? A Large Language Model Benchmark for Candidate Term Extraction and Subclass Decisions Against Upper Ontologies in Engineering and Materials Science

Advanced Engineering Materials, EarlyView.
Building machine‐readable vocabularies for materials science is slow, expert‐driven work. This study benchmarks 13 large language models on two of its first steps: finding candidate terms in engineering articles and deciding where they belong in a class hierarchy.
Thomas Bjarsch, Maximilian Holland, Klaus Drechsler, Johannes Schilp   +3 more
wiley   +1 more source

Die Textilveredlung als inverted classroom mit OPALWiki

Lessons Learned, 2023
Im Rahmen zweiter Lehrveranstaltungen im Bereich Textilveredlung wurde eine inverted classroom-Methode (ICM) in Kombination mit einem Wikipedia (Wikis) umgesetzt. Das Wikipedia ist Teil der Lernplattform OPAL.
Iris Kruppke
doaj