BMJ Open, 2023 Introduction Chronic cytomegalovirus (CMV) infection is very frequent in people living with HIV (PLWH). High anti-CMV IgG titres, which may be linked to transient CMV replication, have been associated with earlier mortality, CD8 T-cell expansion, lower ...
Jean-Pierre Routy +15 more
doaj +1 more source
Large-scale screening of HCMV-seropositive blood donors indicates that HCMV effectively escapes from antibodies by cell-associated spread [PDF]
, 2018 Immunoglobulins are only moderately effective for the treatment of human cytomegalovirus (HCMV) infections, possibly due to ineffectiveness against cell-associated virus spread.
Alt, Mira +9 more
core +2 more sources
Antiviral therapy defiant mixed viral retinitis post hematopoietic allogeneic stem cell transplant
Clinical Case Reports, 2023 Cytomegalovirus (CMV) retinitis is an uncommon presentation post allogeneic transplant and can be vision‐threatening. Our case demonstrates the occurrence of polymerase chain reaction (PCR) proven mixed viral retinitis (cytomegalovirus and varicella ...
Nadia Gabarin +5 more
doaj +1 more source
Suppression of CMV Infection with Letermovir in a Kidney Transplant Patient
European Journal of Case Reports in Internal Medicine, 2020 Infection with cytomegalovirus (CMV) with resistance to ganciclovir (GCV) is a therapeutic challenge in kidney transplant patients, because standard treatment options are nephrotoxic. We report the case of a kidney transplant recipient with GCV-resistant
Uta Köpf +6 more
doaj +1 more source
Microbiology Spectrum, 2022 De novo mutations in the UL56 terminase subunit and its associated phenotypes were studied in the context of cytomegalovirus (CMV) transplant recipients clinically resistant to DNA-polymerase inhibitors, naive to letermovir.
Marta Santos Bravo +14 more
doaj +1 more source
Cost-Effectiveness Analysis Of The Prevention And Treatment Of Cytomegalovirus (CMV) Infections After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) In Adults [PDF]
, 2019 Целта на изследването е да се представи моделиране на локални данни за разходи и здравни ползи на алтернативните антивирусни терапии за профилактика и лечение на цитомегаловирус (CMV) - серопозитивни пациенти след алогенна трансплантация на хемопоетични ...
Gavrilova, Anna +3 more
core +2 more sources
Anti-CMV therapy, what next? A systematic review
Frontiers in Microbiology, 2023 Human cytomegalovirus (HCMV) is one of the main causes of serious complications in immunocompromised patients and after congenital infection. There are currently drugs available to treat HCMV infection, targeting viral polymerase, whose use is ...
Claire Gourin +4 more
doaj +1 more source
Cytomegalovirus Prophylaxis versus Pre-emptive Strategy: Different CD4(+) and CD8(+) T Cell Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation [PDF]
, 2021 Reconstitution of T cells after transplantation is a determinant of the long-term success of the procedure, and the correlation with T cell recovery and cytomegalovirus reactivation and disease is well known.
Candoni A. +10 more
core +1 more source
The Antifungal Drug Isavuconazole Inhibits the Replication of Human Cytomegalovirus (HCMV) and Acts Synergistically with Anti-HCMV Drugs [PDF]
, 2021 We recently reported that some clinically approved antifungal drugs are potent inhibitors of human cytomegalovirus (HCMV). Here, we report the broad-spectrum activity against HCMV of isavuconazole (ICZ), a new extended-spectrum triazolic antifungal drug.
Celegato, Marta +5 more
core +1 more source
Therapeutic Advances in Hematology, 2021 Background: Letermovir prophylaxis is currently the standard of care for the prevention of cytomegalovirus (CMV) infections in allogeneic hematopoietic stem-cell transplantation (allo-HSCT).
Po-Hsien Li +5 more
doaj +1 more source