Results 61 to 70 of about 2,984 (199)

HCMV Antivirals and Strategies to Target the Latent Reservoir. [PDF]

, 2021
Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people, primary infection is generally asymptomatic, and the virus can go on to establish lifelong latency in cells of the myeloid lineage.
Perera, Marianne R, Sinclair, John H, Wills, Mark R   +2 more
core   +2 more sources

Maribavir for Cytomegalovirus Infection in High‐Risk Kidney Transplant Recipients: A Case Series

IJU Case Reports, Volume 9, Issue 3, May 2026.
ABSTRACT Background Cytomegalovirus (CMV) infection remains a common complication after kidney transplantation, particularly among high‐risk donor‐seropositive/recipient‐seronegative (D+/R−) recipients. Valganciclovir is the standard first‐line therapy; however, its use may be limited by hematological toxicity or impaired graft function. Maribavir is a
Daiji Takamoto, Yu Shimada, Yuri Hasegawa, Takeaki Noguchi, Takashi Kawahara, Junichi Teranishi, Kazuhide Makiyama   +6 more
wiley   +1 more source

The Management of Congenital Cytomegalovirus Infection in an Era of Universal Newborn CMV Screening

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The most common infectious disease responsible for paediatric developmental disability is congenital infection with human cytomegalovirus (cCMV). Many serious sequelae are caused by cCMV, including microcephaly, intracranial calcifications, neuronal migration defects, seizure disorders, developmental delay, and sensorineural hearing loss (SNHL)
Emily R. Harrison, W. Charles Huskins, Mark R. Schleiss   +2 more
wiley   +1 more source

Letermovir Administration to Prevent Cytomegalovirus Reactivation Is the Potential Risk of Chronic Graft-Versus-Host Disease in Patients Who Received Haploidentical Stem-Cell Transplantation With Post-Transplant Cyclophosphamide

Frontiers in Oncology, 2021
The prevention of chronic graft-versus-host disease (cGVHD) is important for recipients of hematopoietic stem-cell transplantation (HSCT). As one of the etiologies, the relationship between early T-cell recovery and subsequent cGVHD development has been ...
Toshiki Terao, Ken-ichi Matsuoka, Kentaro Narita, Takafumi Tsushima, Satoshi Yuyama, Ayumi Kuzume, Rikako Tabata, Daisuke Miura, Masami Takeuchi, Kosei Matsue   +9 more
doaj   +1 more source

Effect of antivirals on clinical and lab-adapted human cytomegalovirus strains using induced pluripotent stem cell-derived human neural models [PDF]

Human cytomegalovirus (CMV) infections can cause severe neurological complications, particularly in newborns and immunocompromised patients. Children affected with congenital CMV infection may develop long-term neurological damage and intellectual ...
Calitz, Carlemi, Cornelissen, Marion, Freeze, Eline, Kampen, Jeroen Van, Koen, Gerrit, Korsten, Joep, Molenkamp, Richard, Mulder, Lance A., Pajkrt, Dasja, Schotting, Amber J., Sridhar, Adithya, Vieira da Sá, Renata, Wolthers, Katja C., Zorgdrager, Fokla   +13 more
core   +1 more source

Clinical next-generation sequencing assay combining full-length gene amplification and shotgun sequencing for the detection of CMV drug resistance mutations [PDF]

, 2023
Cytomegalovirus (CMV) causes severe systemic and tissue-invasive disease in immunocompromised patients, particularly solid organ and hematopoietic stem cell transplant recipients.
Caldera, JR, Cerón, Stacey, Chan, June L, Garner, Omai B, Gray, Hannah K, von Bredow, Benjamin, Yang, Shangxin   +6 more
core   +1 more source

Congenital CMV Infection: Determination of Transplacental Passage of Aciclovir by Ex Vivo Placental Perfusion

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 6, Page 1241-1248, May 2026.
ABSTRACT Objective To quantify the transplacental transfer of aciclovir at an amount equivalent to 2 g of valaciclovir corresponding to the fractionated dosing regimen given four times daily used to reduce congenital cytomegalovirus (CMV) transmission and to treat the CMV‐infected fetus. Design Experimental ex vivo study.
Helyett Ollivier, Valentine Faure Bardon, Leo Froelicher Bournaud, Isidore Gaubert, Tiffany Guilleminot, Marianne Leruez‐Ville, Jean‐Marc Treluyer, Yves Ville, Gabrielle Lui, Julien Stirnemann   +9 more
wiley   +1 more source

Clinical and immunological analysis of letermovir for preventing cytomegalovirus infection in children after hematopoietic stem cell transplantation

Frontiers in Immunology
ObjectiveThe present study aimed to analyze the efficacy and safety of letermovir for preventing cytomegalovirus (CMV) infection and its impact on immune reconstitution in children after allogeneic hematopoietic stem cell transplantation (allo-HSCT ...
Qing Liu, Bing Zhou, Na Zhang, Hong Li, Sijian Wang, Shumin Hou, Yilin Wang, Pan Fu, Tianqiao Zhong, Jingbo Shao, Kai Chen, Hui Jiang   +11 more
doaj   +1 more source

Diseño, síntesis y caracterización estructural de compuestos derivados de 2-amino-propano-1,3-diol potencialmente activos como antivirales [PDF]

, 2019
Los adenovirus (AdV) son virus eucariotas con 36000 pares de bases, producen infecciones que son muy comunes y se dan durante todo el año. Las poblaciones susceptibles a la infección por adenovirus (AdV) incluyen niños, pacientes inmunocomprometidos y ...
Muriana Camacho, Claudia
core  

Sensitive and Rapid Dual One‐Tube Recombinase Aided PCR Assays for the Simultaneous Detection of Cytomegalovirus, Epstein‐Barr Virus, Human Herpesvirus 6, and Herpes Simplex Virus 1/2 in Whole Blood From Children Undergoing Hematopoietic Stem Cell Transplantation

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Early, rapid, and sensitive detection of cytomegalovirus (CMV), Epstein‐Barr virus (EBV), human herpesvirus 6 (HHV‐6), and herpes simplex virus Types 1/2 (HSV‐1/2) is critical for improving clinical outcomes in pediatric hematopoietic stem cell transplantation (HSCT).
Li Zhao, Mengchuan Zhao, Yuan Gao, Yanqing Tie, Yinghui Guo, Shuai Zhang, Yuxin Wang, Deran Ma, Zhili Shao, Zhishan Feng   +9 more
wiley   +1 more source