Results 81 to 90 of about 3,523 (219)

Abatacept Prevents Severe Acute Graft‐Versus‐Host Disease Without Increasing Graft Failure Risk in Pediatric Bone Marrow Failure Syndromes

Pediatric Blood &Cancer, Volume 72, Issue 12, December 2025.
ABSTRACT Background Pediatric patients with inherited or acquired bone marrow failure syndromes (BMFS) often require an allogeneic hematopoietic stem cell transplant (HSCT) to cure the hematological manifestations. Amongst these, those without a matched sibling donor (MSD), are at increased risk for graft failure and are known to tolerate graft‐versus ...
Zahra Hudda, Stella M. Davies, Adam Lane, Deborah E. Schiff, Eric J. Anderson, Parinda A. Mehta, Kasiani C. Myers, Nicholas J. Gloude   +7 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, Volume 19, Issue 11, Page 3035-3059, November 2025.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

Management of Cytomegalovirus Infections in the Era of the Novel Antiviral Players, Letermovir and Maribavir

Infectious Disease Reports
Cytomegalovirus (CMV) infections may increase morbidity and mortality in immunocompromised patients. Until recently, standard antiviral drugs against CMV were limited to viral DNA polymerase inhibitors (val)ganciclovir, foscarnet and cidofovir with a ...
Jocelyne Piret, Guy Boivin
doaj   +1 more source

DNA Encapsidation and Capsid Assembly Are Underexploited Antiviral Targets for the Treatment of Herpesviruses

Frontiers in Microbiology, 2020
Although there are effective nucleoside analogs to treat HSV, VZV, and HCMV disease, herpesvirus infections continue to contribute to significant morbidity and mortality. Acyclovir is the drug of choice for HSV encephalopathy, yet there is an estimated 6–
Tara Keil, Dongmei Liu, Megan Lloyd, Wanda Coombs, Jennifer Moffat, Robert Visalli   +5 more
doaj   +1 more source

Valganciclovir Underdosing Is Associated With Cytomegalovirus DNAemia During Universal Prophylaxis: A Real‐Life Case Control Retrospective Study

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT Universal prophylaxis or a preemptive strategy with valganciclovir (VGCV) is recommended for prevention of cytomegalovirus (CMV) infections after kidney transplantation. We combined both strategies during the first 3 months post‐transplantation.
Pierre‐Antonin Rigon, Justine Solignac, Christine Zandotti, Marion Gully, Philippe Brunet, Noémie Resseguier, Tristan Legris, Valérie Moal   +7 more
wiley   +1 more source

The Changing Impact of Human Cytomegalovirus Serology and Infection on Patient Outcome After Allogeneic Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey in the Era of Letermovir Prophylaxis [PDF]

Background: In the letermovir primary prophylaxis (LET-PP) era, the epidemiology of human cytomegalovirus infection (HCMV-i) in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients has changed.
Baldanti, Fausto, Bonifazi, Francesca, Bono, Roberto, Bramanti, Stefania, Busca, Alessandro, Carella, Angelo Michele, Carotti, Alessandra, Castagna, Luca, Cavattoni, Irene Maria, Chiusolo, Patrizia, Ciceri, Fabio, Clerici, Pierangelo, Cutini, Ilaria, Faraci, Maura, Galaverna, Federica, Girmenia, Corrado, Greco, Raffaella, Iori, Anna Paola, Lazzarotto, Tiziana, Malagola, Michele, Marsili, Giovanni, Martino, Massimo, Micò, Maria Caterina, Onida, Francesco, Picardi, Alessandra, Piciocchi, Alfonso, Porto, Gaetana, Rinaldi, Amelia, Terruzzi, Elisabetta, Vacca, Adriana   +29 more
core   +1 more source

Has early mortality following single‐unit unrelated cord blood transplantation improved in recent years? A nationwide registry data analysis from 2003 to 2022 in Japan

British Journal of Haematology, Volume 207, Issue 5, Page 2026-2040, November 2025.
The 100‐day non‐relapse mortality after single‐unit cord blood transplantation significantly declined from 19.6% (2003–2007) to 9.5% (2018–2022), while the 3‐year overall survival improved from 38.8% to 54.4%. Haematopoietic recovery rates improved steadily, with neutrophil engraftment reaching 89.6% and platelet engraftment 78.0% in the most recent ...
Takaaki Konuma, Junya Kanda, Naoyuki Uchida, Masatsugu Tanaka, Fumihiko Kimura, Hideki Nakasone, Yasufumi Uehara, Masahito Tokunaga, Masako Toyosaki, Shigesaburo Miyakoshi, Noriko Doki, Kazuya Ishiwata, Hikaru Kobayashi, Yasushi Onishi, Yasuji Kozai, Koji Kato, Fumihiko Ishimaru, Takahiro Fukuda, Yoshiko Atsuta, Satoshi Takahashi   +19 more
wiley   +1 more source

Advances in CMV Management: A Single Center Real-Life Experience

Frontiers in Cell and Developmental Biology, 2020
CMV infection is a major challenge in allogeneic stem cell transplantation (allo-SCT). The changing landscape in CMV management includes the introduction of letermovir in prophylaxis of high-risk patients and the source of CMV DNA monitoring (plasma—PL ...
Michele Malagola, Caterina Pollara, Nicola Polverelli, Tatiana Zollner, Daria Bettoni, Lisa Gandolfi, Doriana Gramegna, Enrico Morello, Alessandro Turra, Silvia Corbellini, Liana Signorini, Giovanni Moioli, Simona Bernardi, Simona Bernardi, Camilla Zanaglio, Camilla Zanaglio, Mirko Farina, Tullio Elia Testa, Arnaldo Caruso, Domenico Russo   +19 more
doaj   +1 more source

Recent advances in cytomegalovirus infection management in solid organ transplant recipients [PDF]

Purpose of review Human cytomegalovirus (CMV) continues to be the most important infectious complication following solid organ transplantation (SOT).
Grossi P. A., Peghin M.
core   +1 more source