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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1990 Methyl methanesulfonate (MMS) induces specific-locus and dominant lethal mutations in spermatozoa and spermatids of mice. A dose of 15 mg/kg b.w. of MMS induces 9% dominant lethal mutations in the most sensitive germ-cell stages, corresponding to the ...
U H Ehling, A Neuhäuser-Klaus
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International Journal of Veterinary Science and Medicine, 2016 One million people throughout the world are bitten yearly by poisonous snakes. Of this, one-tenth died and three-tenth suffer some forms of disabilities.
Saganuwan Alhaji Saganuwan
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Lethality in the Rat as a Function of Dose Pattern
The British Journal of Radiology, 1958Rats exposed seven days to a chronic field of 2 r/hour of 60Co γ rays immediately prior to or immediately after an acute dose of 800 r of 60Co γ rays did not exhibit a significant difference in either a 30-day or 90-day mortality. When compared to a group of rats receiving only an acute dose of 800 r of 60Co γ rays, both acute-chronic groups evidenced ...
Q L, HARTWIG +2 more
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Interval Estimation of the Median Lethal Dose
Biometrics, 1986Assuming a logistic dose-response curve, one can construct a confidence interval for the LD50 from the asymptotic likelihood ratio test. Reasons are given for preferring this likelihood ratio interval to the established interval calculated by applying Fieller's theorem to the maximum likelihood estimates.
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ROBUST ESTIMATION OF THE MEDIAN LETHAL DOSE
Journal of Biopharmaceutical Statistics, 2002Alternatives to M-estimation for robust estimation of the median lethal dose in biological assays are developed. A class of link functions based on the Student-t distribution is proposed, where degrees of freedom are estimated from the data by maximum likelihood. Other alternatives include slash and finite mixture distributions.
G E, Kelly, J K, Lindsey
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Science, 2013
A new generation of genetically modified crops will kill insects by silencing their genes.
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A new generation of genetically modified crops will kill insects by silencing their genes.
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The median lethal dose and its estimation
Archives of Toxicology, 1985An important paper by Zbinden and Fluri-Roversi (1981) has shown the many weaknesses in any policy or regulatory system that regards an estimated LD50 in an animal species as an adequate guide to toxicity in man. The present paper draws attention to some statistical aspects of LD50 estimation that are too often neglected or misunderstood when this ...
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Doctors admit lethal doses administered
Nursing Standard, 1991Doctors admitted they had administered lethal drug doses at patients' requests in 1.8 per cent of deaths studied in a survey in the Netherlands.
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Determination of Lethal Dose in a Protozoa
Investigative Radiology, 1981Suitability of a protozoan culture for determination of contrast media (CM) toxicity was investigated. A culture of Blepharisma americanum was exposed to varying concentrations of CM and the time elapsed until 50% cell mortality was determined. The cultures were standardized using solutions of Na iothalamate and/or Metrizamide.
M, Sovak, R, Ranganathan, W, Mutzel
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Survival After a Lethal Dose of Arsenic Trioxide
Journal of Toxicology: Clinical Toxicology, 2004A case of a 27-year-old woman who ingested 9000 mg arsenic trioxide (As2O3) is reported. Classical symptoms of an acute arsenicum (As) poisoning such as gastrointestinal cramps, vomiting, diarrhea, ECG changes and disturbed liver function tests were observed.
Barbara, Vantroyen +7 more
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